Papers - KOBAYASHI Jun
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A novel method to assess the severity and prognosis in crush syndrome by assessment of skin damage in hairless rats Reviewed
Murata I, Kawanishi R, Inoue S, Iwata M, Kobayashi J, Inoue Y, Kanamoto I
European Journal of Trauma and Emergency Surgery 2018
Language：English Publishing type：Research paper (scientific journal)
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Dietary nitrite reverses features of postmenopausal metabolic syndrome induced by high-fat diet and ovariectomy in mice. Reviewed
Ohtake K, Ehara N, Chiba H, Nakano G, Sonoda K, Ito J, Uchida H, Kobayashi J.
American Journal of Physiology Endocrinology and Metabolism 312 ( 4 ) E300 - E308 2017
Language：English Publishing type：Research paper (scientific journal)
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Interaction between nitrite and nifedipine in blood pressure of L-NAME-induced hypertensive rat. Reviewed
Kunihiro Sonoda, Kazuo Ohtake, Hiroyuki Uchida, Hazuki Tamada, Jun Kobayashi
Bulletin of the Institute for Consumer Sciences and Human Life, Kinjo Gakuin Unversity 22 ( 1 ) 7 - 16 2017
Language：Japanese Publishing type：Research paper (bulletin of university, research institution) Publisher：Kinjo Gakuin Unversity
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No Association of Caffeinated Beverage or Caffeine Intake with Prevalence of Urinary Incontinence Among Middle-Aged Japanese Women: A Multicenter Cross-Sectional Study Reviewed
Saito M, Kobayashi S, Uchida H, Suga H, Kobayashi J, Sasaki S, the Three-Generation Study of Women on Diets and Health Study Group
Journal of Women's Health 2017
Language：English Publishing type：Research paper (scientific journal)
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Inducible and neuronal nitric oxide synthases exert contrasting effects during rat intestinal recovery following fasting. Reviewed
Ito J, Uchida H, Machida N, Ohtake K, Saito Y, Kobayashi J
Experimental Biology and Medicine 242 ( 7 ) 762 - 772 2017
Language：English Publishing type：Research paper (scientific journal)
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Dietary nitrite supplementation attenuates cardiac remodeling in l-NAME-induced hypertensive rats. Reviewed
Sonoda K, Ohtake K, Uchida H, Ito J, Uchida M, Natsume H, Kobayashi J
Nitric Oxide 67 1 - 9 2017
Language：English Publishing type：Research paper (scientific journal)
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Identification of the cysteine residue responsible for oxidative inactivation of mouse galectin-2. Reviewed
Tamura M, Sasai A, Ozawa R, Saito M, Yamamoto K, Takeuchi T, Kobayashi J, Arata Y
Journal of biochemistry 160 ( 4 ) 233 - 241 2016
Language：English Publishing type：Research paper (scientific journal)
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NO-Rich Diet for Lifestyle-Related Diseases Invited Reviewed
Jun Kobayashi, Kazuo Ohtake, Hiroyuki Uchida
Nutrients 7 ( 6 ) 4911 - 4937 2015.07
Language：English Publishing type：Research paper (scientific journal)
Abstract: Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO generation by transmitting NO activities in the various molecular forms including NO and protein S-nitrosothiols. Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. This review provides an overview of our current knowledge of NO generation through the entero-salivary pathway and discusses its safety and preventive effects on lifestyle-related diseases.
DOI： 10.3390/nu7064911
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Nitric oxide and insulin resistance. Reviewed
Jun Kobayashi
Immunoendocrinology 2015.03
Language：English Publishing type：Research paper (scientific journal)
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Insulin resistance and diet care. Invited Reviewed
Jun Kobayashi
J Nutr Med Diet Care 1 003e 2015.03
Language：English Publishing type：Research paper (scientific journal)
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Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKA(y) mice. Reviewed
Ohtake K, Nakano G, Ehara N, Sonoda K, Ito J, Uchida H, Kobayashi J.
Nitric Oxide Biology and Chemistry 44 31 - 38 2015.02
Language：English Publishing type：Research paper (scientific journal)
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Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat Reviewed
Kunihiro Sonoda1, Kazuo Ohtake2, Yoshinori Kubo2, Hiroyuki Uchida2; Masaki Uchida 3, Hideshi Natsume3, Miya Kobayashi 1 and Jun Kobayashi
Clin Exp Hypertension in press 2013.12
Language：English Publishing type：Research paper (scientific journal)
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Acute lethal crush-injured rats can be successfully rescued by a single injection of high-dose dexamethasone through a pathway involving PI3K-Akt-eNOS signaling. Reviewed
Murata I, Ooi K, Shoji S, Motohashi Y, Kan M, Ohtake K, Kimura S, Ueda H, Nakano G, Sonoda K, Inoue Y, Uchida H, Kanamoto I, Morimoto Y, Kobayashi J.
J Trauma Acute Care Surg 75 ( 2 ) 241 - 249 2013.02
Language：English Publishing type：Research paper (scientific journal)
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Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model. Reviewed
Murata I, Nozak Ri, Ooi K, Ohtake K, Kimura S, Ueda H, Nakano G, Sonoda K, Inoue Y, Uchida H, Kanamoto I, Morimoto Y, Kobayashi J.
J. Trauma 72 1548 - 1554 2012.04
Language：English Publishing type：Research paper (scientific journal)
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Effect of Poly-L-arginine on Intestinal Absorption of Hydrophilic Macromolecules in Rats. Reviewed
Yamaki T, Ohtake K, Ichikawa K, Uchida M, Uchida H, Ohshima S, Juni K, Kobayashi J, Morimoto Y, Natsume H.
Biol. Pharm. Bull. 36 ( 3 ) 496 - 500 2012.03
Language：English Publishing type：Research paper (scientific journal)
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b12-00974
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Poly-L-arginine-Induced Internalization of Tight Junction Proteins Increases the Paracellular Permeability of the Caco-2 Cell Monolayer to Hydrophilic Macromolecules. Reviewed
Yamaki T, Uchida U, Kuwahara Y, Shimazaki Y, Ohtake K, Kimura M, Uchida H, Kobayashi J, Ogihara M, Morimoto Y, Natsume H.
Biol. Pharm. Bull. 36 ( 3 ) 432 - 441 2012.03
Language：English Publishing type：Research paper (scientific journal)
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b12-00878
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Characterization of systemic and histologic injury following crush syndrome and intervals of reperfusion in a small animal model. Reviewed
Murata I, Ooi K, Sasaki H, Kimura S, Ohtake K, Ueda H, Uchida H, Yasui N, Tsutsui Y, Yoshizawa N, Hirotsu I, Morimoto Y, and Kobayashi J.
J Trauma 70 ( 6 ) 1453 - 1463 2011.06
Language：English Publishing type：Research paper (scientific journal)
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Intranasal administration of milnacipran in rats: Evaluation of the transport of drugs to the systemic circulation and central nervous system and the pharmacological effect. Reviewed
Uchida M, Katoh T, Mori M, Maeno T, Ohtake K, Kobayashi J, Morimoto Y, Natsume H.
Biol. Pharm. Bull. 34 ( 5 ) 740 - 747 2011.05
Language：English Publishing type：Research paper (scientific journal)
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.34.740
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Age-, period-, and birth-cohort-specific effects on the male proportion in Japanese newborns and projections for male proportion for 20 periods (2008-2027). Reviewed
Uchida H, Watanabe M, Naiki M, Ito J, Ohtake K, Odagiri Y, Kobayashi J.
日本衛生学学会誌 66 582 - 588 2011.04
Language：Japanese Publishing type：Research paper (scientific journal)
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Oral Nitrite Ameliorates Dextran Sulfate Sodium-induced Acute Experimental Colitis in Mice. Reviewed
Kazuo Ohtake, Midori Koga, Hiroyuki Uchida, Kunihiro Sonoda, Junta Ito, Masaki Uchida, Hideshi Natsume and Jun Kobayashi.
Nitric Oxide 23 ( 1 ) 65 - 73 2010.04
Language：English Publishing type：Research paper (scientific journal)
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-j.niox.2010.04.004