Papers - KUDO Naomi
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Reduction in Secretion of Very Low Density Lipoprotein–Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia Reviewed International journal
Yoichi Kawashima, Yoshihiro Eguchi, Tohru Yamazaki, Minako Karahashi, Hiroshi Kawai, and Naomi Kudo
Journal of Pharmacology and Experimental Therapeutics 366 ( 7 ) 194 - 204 2018.07
Language：English Publishing type：Research paper (scientific journal) Publisher：The American Society of Pharmacology and Experimental Therapeutics
Matrix metalloproteinase inhibitors (MMPIs) reduced serum triacylglycerol (TAG) levels in streptozotocin-induced diabetic rats and Zucker fa/fa rats in our previous study. However, the mechanisms underlying TAG reduction by MMPIs remain unclear. The present study aimed to elucidate the mechanism by which F81-1144b, an MMPI, lowers serum TAG levels in an animal model of high-sucrose diet (HSD)-induced hypertriglyceridemia. F81-1144b was repeatedly administered to rats fed HSD, and its effects were evaluated on TAG levels in serum and the liver, very low density lipoprotein (VLDL) secretion, de novo fatty acid (FA) synthesis in the liver, and the expression of genes regulating the metabolism of FA, TAG, and VLDL in the liver and serum. F81-1144b lowered TAG levels in serum and the liver, VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose. F81-1144b suppressed the expression of genes related to the de novo synthesis of FA and TAG, key proteins (lipin 1 and apolipoprotein CIII) responsible for VLDL metabolism, and sterol regulatory element-binding protein-1c and carbohydrate response element-binding protein. F81-1144b little affected the expression of genes related directly to the degradation of TAG or FA, but it upregulated that of gene for uncoupling protein 2 in the liver. These results suggest that MMPIs are a novel type of therapeutic agent for the treatment of hypertriglyceridemia, because the metabolic effects of F81-1144b expected from changes in the expression of genes regulating lipid metabolism would alter metabolism differently from those induced by fibrates, niacin, or n-3 FAs.
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Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats Reviewed International journal
Hiroshi Kawai, Natsumi Kodaira, Chika Tanaka, Takuya Ishibashi, Naomi Kudo, YoichiKawashima, Atsushi Mitsumoto
Journal of Circadian Rhythms 16 5 2018.05
Language：English Publishing type：Research paper (scientific journal) Publisher：Bio Med Central
The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility and increased climbing in the FST. The plasma concentrations of imipramine and its metabolite, desipramine, were slightly higher in the morning than in the evening, which might explain the dosing time-dependent action of imipramine. Next, we analyzed the effect of chronic imipramine treatment. Rats received imipramine in the morning or in the evening for 2 weeks. The morning treatment resulted in larger effects in the FST than the evening treatment, and was effective at a dose that was ineffective when administered acutely. The levels of brain α-adrenergic receptors tended to decrease after chronic imipramine treatment. Imipramine might interact with noradrenergic neurons, and this interaction might chronically alter receptor expression. This alteration seemed greater in the morning than in the evening, which might explain the dosing time-dependent action of imipramine.
DOI： 10.5334/jcr.156
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Hiroshi Kawai, Megumi Machida, Takuya Ishibashi, Naomi Kudo, Yoichi Ka ...
Biological and Pharmaceutical Bulletin 41 ( 2 ) 213 - 219 2018.02
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Sciety of Japan
Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran in the morning (8:00 a.m.; zeitgeber time [ZT]1) or in the evening (8:00 p.m.; ZT13) were analyzed in a forced swim test (FST). At ZT1, the rats’ immobility was reduced and the swimming was increased, whereas at ZT13, their climbing was increased. These results suggest that the serotonergic and noradrenergic systems are preferentially affected at ZT1 and ZT13, respectively by milnacipran. We analyzed the plasma and brain levels of milnacipran after administration, and there were no differences between ZT1 and ZT13. The circadian rhythm of monoamine neurotransmitters was analyzed in several brain regions. The serotonin turnover showed rhythms with a peak during ZT18–ZT22 in hippocampus. The noradrenaline turnover showed rhythms with a peak during ZT22–ZT2. There was a difference of approx. 4 h between the serotonergic and noradrenergic systems. This time difference might be one of the factors that affect the action of milnacipran and contribute to the dosing time-dependent behavioral pattern in the FST.
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Hiroshi KAWAI, Jin INABE, Takuya ISHIBASHI, Naomi KUDO, Yoichi KAWASHI ...
Biomedical Research 39 ( 1 ) 47 - 55 2018.02
Language：English Publishing type：Research paper (scientific journal) Publisher：Biomedical Research Press
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Disposition of perfluorododecanoic acid in male rats after an oral administration Reviewed
Fundamental Toxicological Sciences 4 ( 4 ) 179 - 186 2017.07
Language：English Publishing type：Research paper (scientific journal) Publisher：日本毒性学会
DOI： 10.2131/fts.4.179
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Perfluorododecanoic acid induces cognitive deficit in adult rats Reviewed
Kawabata, K., Matsuzaki, H., Nukui, S., Okazaki, M., Sakai, A., Kawashima, Y., Kudo, N.
Toxicological Sciences 157 421 - 428 2017
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Society of Toxicology (USA)
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Fatty Acid β-Oxidation plays a key role in regulating cis-palmitoleic acid levels in the liver Reviewed
Kawabata, K., Karahashi, M., Sakamoto, T., Tsuji, Y., YamazakiT., Okazaki, M., Mitsumoto, A., Kudo, N., Kawashima, Y.
Biological and Pharmaceutical Bulletin 39 1995 - 2008 2016
Language：English Publishing type：Research paper (scientific journal) Publisher：The pahrmaceutical Society of Japan
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Abnormalities in the metabolism of fatty acids and triacylglycerols in the liver of the Goto-Kakizaki rat, a model for non-obese type 2 diabetes. Reviewed
3. Karahashi, M., Hirata-Hanta, Y., Kawabata, K., Tsutsumi, D., Kametani, M., Takamatsu, N., Sakamoto, T., Yamazaki, T., Asano, S., Mitsumoto., Kawashima, Y., Kudo, N.
Lipids 55 955 - 971 2016
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer, Americal Oil Chemists' Society
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Effects of dietary fish oil on cytochrome P450 3A expression in the liver of SHR/NDmcr-cp(cp/cp) rats, an animal model for metabolic syndrome. Reviewed
Yamazaki, T., Ohki, T., Taguchi, H., Yamamoto, A., Okazaki, M., Sakamoto, T., Mitsumoto, A., Kawashima, Y., Kudo, N.
Fundamental Toxicological Sciences 2 127 - 135 2015
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Tooxicology
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Inducing effect of clofibric acid on stearoyl-CoA desaturase in intestinal mucosa of rats. Reviewed
2. Yamazaki, T., Kadokura, M., Mutoh, Y., Sakamoto, T., Okazaki, M., Mitsumoto, A., Kawashima, Y., Kudo, N.
Lipids 49 1203 - 1214 2014.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer American Oil Chemist's Society
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A simple and sensitive method for the determination of fibric acids in the liver by liquid chromatography Reviewed
Karahashi, M., Fukuhara, H., Hoshimna, M., Sakamoto, T., Yamazaki, T., Mitsumoto, A., Kawashima, Y., Kudo, N.
Biological and Pharmaceutical Bulletin 37 ( 1 ) 105 - 112 2014.01
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceuticl Sciety of Japan
Fibrates are used in biochemical and pharmacological studies as bioactive tools. Nevertheless, most studies have lacked information concerning the concentrations of fibric acids working inside tissues because a simple and sensitive method is not available for their quantitation. This study aimed to develop a simple and sensitive bioanalytical method for the quantitation of clofibric, bezafibric and fenofibric acids in samples of very small portions of tissues. Fibric acids were extracted into n-hexane–ethyl acetate from tissue homogenates (10 mg of liver, kidney or muscle) or serum (100 µL) and were derivatized with 4-bromomethyl-6,7-dimethoxycoumarin, followed by HPLC with fluorescence detection. These compounds were separated isocratically on a reversed phase with acetonitrile–water. Standard analytical curves were linear over the concentration range of 0.2–20 nmol/10 mg of liver. Precision and accuracy were within acceptable limits. Recovery from liver homogenates ranged from 93.03 to 112.29%. This method enabled the quantitation of fibric acids in 10 mg of liver from rats treated with clofibric acid, bezafibric acid or fenofibrate. From these analytical data, it became clear that there was no large difference in ratio of acyl-CoA oxidase 1 (Acox1) mRNA level to fibric acid content in the liver among the three fibric acids, suggesting that these three fibric acids have similar potency to increase expression of the Acox1 gene, which is a target of peroxisome proliferator-activated receptor α. Thus, the proposed method is a simple, sensitive and reliable tool for the quantitation of fibric acids working in vivo inside livers.
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Fibrates reduce triacylglycerol content by up-regulating adipose triglyceride lipase in the liver of rats Reviewed
Karahashi, M., Hoshina, M., Yamazaki, T., Sakamoto, T., Mitsumoto, A., Kawashima, Y., Kudo, N.
Journal of Pharmacological Sciences 123 356 - 370 2013.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Pharmacologycal Society
DOI： 10.1254/jphs.13149FP
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Altered fatty acid profile in the liver and serum of stroke-prone spontaneously hypertensive rats: Reduced proportion of cic-vaccenic acid. Reviewed
Tanaka, S., Yamazaki, T., Asano, S., Mitsumoto, A., Kobayashi, D., Kudo, N., Kawashima, Y.
Journal of Oleo Science 62 ( 11 ) 933 - 948 2013.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Oil Chemists' Society
DOI： 10.5650/jos.62.933
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Perturbation of lipid metabolism in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model of metabolic syndrome. Reviewed
Tanaka, S., Yamazaki, T., Asano, S., Mitsumoto, A., Kobayashi, D., Kudo, N., Kawashima, Y.
Lipids 48 1115 - 1134 2013.09
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer American Oil Chemists' Society
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Up-regulation of stearoyl-CoA desaturase 1increases liver MUFA content in obese Zucker but not Goto-Kakizaki rats. Reviewed
Karahashi, M., Ishii, F., Yamazaki, T., Imai, K., Mitsumoto, A., Kawashima, Y., Kudo, N.
Lipids 48 457 - 467 2013.03
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer American Oil Chemist' Society
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Characterization of fatty acid profile in the liver of SHR/NDmcr-cp (cp/cp) rats, a model of the metabolic syndrome. Reviewed
Tanaka, S., Yagi, Y., Yamazaki, T., Mitsumoto, A., Kobayashi, D., Kudo, N., Kawashima, Y.
Biological and Pharmaceutical Bulletin 35 ( 2 ) 184 - 191 2012.11
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pahrmaceutical Society of Japan
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Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats. Reviewed
Yamazaki, T., Wakabayashi, M., Ikeda, E., Tanaka, S., Sakamoto, T., Mitsumoto, A., Kudo, N., Kawashima, Y.
Biological and Pharmaceutical Bulletin 35 ( 9 ) 1505 - 1515 2012.06
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
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Differential Induction of Stearoyl-CoA Desaturase 1 and 2 genes by Fibrates in the Liver of Rats. Reviewed
Yamazaki, T., Okada, H., Sakamoto, T., Sunaga, K., Tsuda, T., Mitsumoto, A., Kudo, N. and Kawashima, Y.
Biological and Pharmaceutical Bulletin 35 ( 1 ) 116 - 120 2012.01
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
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Behavioral and biochemical characterization of rats treated chronically with thioacetamide: proposal of an animal model for hepatic encephalopathy associated with cirrhosis Reviewed
Kawai, H., Ishibashi, T., Kudo, N., Kawashima, Y., Mitsumoto, A.
Journal of Toxicological Sciences 37 1165 - 1175 2012
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Toxicology
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Impairment of heme biosynthesis induces short circadian period in body temperature rythms in mice.
Iwadate, R., Satoh, Y., Watanabe, Y., Kawai, H., Kudo, N., Kawashima, Y., Mitsumoto, A.
Am. J. Physiol. Regul. Integr. Comp, Physiol. 303 R8 - R18 2012
Language：English Publishing type：Research paper (scientific journal) Publisher：American Physiological Society