Papers - KUDO Naomi
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Reduction in Secretion of Very Low Density Lipoprotein–Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia Reviewed International journal
Yoichi Kawashima, Yoshihiro Eguchi, Tohru Yamazaki, Minako Karahashi, Hiroshi Kawai, and Naomi Kudo
Journal of Pharmacology and Experimental Therapeutics 366 ( 7 ) 194 - 204 2018.07
Language：English Publishing type：Research paper (scientific journal) Publisher：The American Society of Pharmacology and Experimental Therapeutics
Matrix metalloproteinase inhibitors (MMPIs) reduced serum triacylglycerol (TAG) levels in streptozotocin-induced diabetic rats and Zucker fa/fa rats in our previous study. However, the mechanisms underlying TAG reduction by MMPIs remain unclear. The present study aimed to elucidate the mechanism by which F81-1144b, an MMPI, lowers serum TAG levels in an animal model of high-sucrose diet (HSD)-induced hypertriglyceridemia. F81-1144b was repeatedly administered to rats fed HSD, and its effects were evaluated on TAG levels in serum and the liver, very low density lipoprotein (VLDL) secretion, de novo fatty acid (FA) synthesis in the liver, and the expression of genes regulating the metabolism of FA, TAG, and VLDL in the liver and serum. F81-1144b lowered TAG levels in serum and the liver, VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose. F81-1144b suppressed the expression of genes related to the de novo synthesis of FA and TAG, key proteins (lipin 1 and apolipoprotein CIII) responsible for VLDL metabolism, and sterol regulatory element-binding protein-1c and carbohydrate response element-binding protein. F81-1144b little affected the expression of genes related directly to the degradation of TAG or FA, but it upregulated that of gene for uncoupling protein 2 in the liver. These results suggest that MMPIs are a novel type of therapeutic agent for the treatment of hypertriglyceridemia, because the metabolic effects of F81-1144b expected from changes in the expression of genes regulating lipid metabolism would alter metabolism differently from those induced by fibrates, niacin, or n-3 FAs.
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Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats Reviewed International journal
Hiroshi Kawai, Natsumi Kodaira, Chika Tanaka, Takuya Ishibashi, Naomi Kudo, YoichiKawashima, Atsushi Mitsumoto
Journal of Circadian Rhythms 16 5 2018.05
Language：English Publishing type：Research paper (scientific journal) Publisher：Bio Med Central
The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility and increased climbing in the FST. The plasma concentrations of imipramine and its metabolite, desipramine, were slightly higher in the morning than in the evening, which might explain the dosing time-dependent action of imipramine. Next, we analyzed the effect of chronic imipramine treatment. Rats received imipramine in the morning or in the evening for 2 weeks. The morning treatment resulted in larger effects in the FST than the evening treatment, and was effective at a dose that was ineffective when administered acutely. The levels of brain α-adrenergic receptors tended to decrease after chronic imipramine treatment. Imipramine might interact with noradrenergic neurons, and this interaction might chronically alter receptor expression. This alteration seemed greater in the morning than in the evening, which might explain the dosing time-dependent action of imipramine.
DOI： 10.5334/jcr.156
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Hiroshi Kawai, Megumi Machida, Takuya Ishibashi, Naomi Kudo, Yoichi Ka ...
Biological and Pharmaceutical Bulletin 41 ( 2 ) 213 - 219 2018.02
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Sciety of Japan
Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran in the morning (8:00 a.m.; zeitgeber time [ZT]1) or in the evening (8:00 p.m.; ZT13) were analyzed in a forced swim test (FST). At ZT1, the rats’ immobility was reduced and the swimming was increased, whereas at ZT13, their climbing was increased. These results suggest that the serotonergic and noradrenergic systems are preferentially affected at ZT1 and ZT13, respectively by milnacipran. We analyzed the plasma and brain levels of milnacipran after administration, and there were no differences between ZT1 and ZT13. The circadian rhythm of monoamine neurotransmitters was analyzed in several brain regions. The serotonin turnover showed rhythms with a peak during ZT18–ZT22 in hippocampus. The noradrenaline turnover showed rhythms with a peak during ZT22–ZT2. There was a difference of approx. 4 h between the serotonergic and noradrenergic systems. This time difference might be one of the factors that affect the action of milnacipran and contribute to the dosing time-dependent behavioral pattern in the FST.
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Hiroshi KAWAI, Jin INABE, Takuya ISHIBASHI, Naomi KUDO, Yoichi KAWASHI ...
Biomedical Research 39 ( 1 ) 47 - 55 2018.02
Language：English Publishing type：Research paper (scientific journal) Publisher：Biomedical Research Press
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Disposition of perfluorododecanoic acid in male rats after an oral administration Reviewed
Fundamental Toxicological Sciences 4 ( 4 ) 179 - 186 2017.07
Language：English Publishing type：Research paper (scientific journal) Publisher：日本毒性学会
DOI： 10.2131/fts.4.179
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Perfluorododecanoic acid induces cognitive deficit in adult rats Reviewed
Kawabata, K., Matsuzaki, H., Nukui, S., Okazaki, M., Sakai, A., Kawashima, Y., Kudo, N.
Toxicological Sciences 157 421 - 428 2017
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Society of Toxicology (USA)
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Fatty Acid β-Oxidation plays a key role in regulating cis-palmitoleic acid levels in the liver Reviewed
Kawabata, K., Karahashi, M., Sakamoto, T., Tsuji, Y., YamazakiT., Okazaki, M., Mitsumoto, A., Kudo, N., Kawashima, Y.
Biological and Pharmaceutical Bulletin 39 1995 - 2008 2016
Language：English Publishing type：Research paper (scientific journal) Publisher：The pahrmaceutical Society of Japan
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Abnormalities in the metabolism of fatty acids and triacylglycerols in the liver of the Goto-Kakizaki rat, a model for non-obese type 2 diabetes. Reviewed
3. Karahashi, M., Hirata-Hanta, Y., Kawabata, K., Tsutsumi, D., Kametani, M., Takamatsu, N., Sakamoto, T., Yamazaki, T., Asano, S., Mitsumoto., Kawashima, Y., Kudo, N.
Lipids 55 955 - 971 2016
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer, Americal Oil Chemists' Society
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Effects of dietary fish oil on cytochrome P450 3A expression in the liver of SHR/NDmcr-cp(cp/cp) rats, an animal model for metabolic syndrome. Reviewed
Yamazaki, T., Ohki, T., Taguchi, H., Yamamoto, A., Okazaki, M., Sakamoto, T., Mitsumoto, A., Kawashima, Y., Kudo, N.
Fundamental Toxicological Sciences 2 127 - 135 2015
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Tooxicology
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Inducing effect of clofibric acid on stearoyl-CoA desaturase in intestinal mucosa of rats. Reviewed
2. Yamazaki, T., Kadokura, M., Mutoh, Y., Sakamoto, T., Okazaki, M., Mitsumoto, A., Kawashima, Y., Kudo, N.
Lipids 49 1203 - 1214 2014.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer American Oil Chemist's Society
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A simple and sensitive method for the determination of fibric acids in the liver by liquid chromatography Reviewed
Karahashi, M., Fukuhara, H., Hoshimna, M., Sakamoto, T., Yamazaki, T., Mitsumoto, A., Kawashima, Y., Kudo, N.
Biological and Pharmaceutical Bulletin 37 ( 1 ) 105 - 112 2014.01
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceuticl Sciety of Japan
Fibrates are used in biochemical and pharmacological studies as bioactive tools. Nevertheless, most studies have lacked information concerning the concentrations of fibric acids working inside tissues because a simple and sensitive method is not available for their quantitation. This study aimed to develop a simple and sensitive bioanalytical method for the quantitation of clofibric, bezafibric and fenofibric acids in samples of very small portions of tissues. Fibric acids were extracted into n-hexane–ethyl acetate from tissue homogenates (10 mg of liver, kidney or muscle) or serum (100 µL) and were derivatized with 4-bromomethyl-6,7-dimethoxycoumarin, followed by HPLC with fluorescence detection. These compounds were separated isocratically on a reversed phase with acetonitrile–water. Standard analytical curves were linear over the concentration range of 0.2–20 nmol/10 mg of liver. Precision and accuracy were within acceptable limits. Recovery from liver homogenates ranged from 93.03 to 112.29%. This method enabled the quantitation of fibric acids in 10 mg of liver from rats treated with clofibric acid, bezafibric acid or fenofibrate. From these analytical data, it became clear that there was no large difference in ratio of acyl-CoA oxidase 1 (Acox1) mRNA level to fibric acid content in the liver among the three fibric acids, suggesting that these three fibric acids have similar potency to increase expression of the Acox1 gene, which is a target of peroxisome proliferator-activated receptor α. Thus, the proposed method is a simple, sensitive and reliable tool for the quantitation of fibric acids working in vivo inside livers.
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Fibrates reduce triacylglycerol content by up-regulating adipose triglyceride lipase in the liver of rats Reviewed
Karahashi, M., Hoshina, M., Yamazaki, T., Sakamoto, T., Mitsumoto, A., Kawashima, Y., Kudo, N.
Journal of Pharmacological Sciences 123 356 - 370 2013.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Pharmacologycal Society
DOI： 10.1254/jphs.13149FP
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Altered fatty acid profile in the liver and serum of stroke-prone spontaneously hypertensive rats: Reduced proportion of cic-vaccenic acid. Reviewed
Tanaka, S., Yamazaki, T., Asano, S., Mitsumoto, A., Kobayashi, D., Kudo, N., Kawashima, Y.
Journal of Oleo Science 62 ( 11 ) 933 - 948 2013.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Oil Chemists' Society
DOI： 10.5650/jos.62.933
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Perturbation of lipid metabolism in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model of metabolic syndrome. Reviewed
Tanaka, S., Yamazaki, T., Asano, S., Mitsumoto, A., Kobayashi, D., Kudo, N., Kawashima, Y.
Lipids 48 1115 - 1134 2013.09
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer American Oil Chemists' Society
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Up-regulation of stearoyl-CoA desaturase 1increases liver MUFA content in obese Zucker but not Goto-Kakizaki rats. Reviewed
Karahashi, M., Ishii, F., Yamazaki, T., Imai, K., Mitsumoto, A., Kawashima, Y., Kudo, N.
Lipids 48 457 - 467 2013.03
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer American Oil Chemist' Society
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Characterization of fatty acid profile in the liver of SHR/NDmcr-cp (cp/cp) rats, a model of the metabolic syndrome. Reviewed
Tanaka, S., Yagi, Y., Yamazaki, T., Mitsumoto, A., Kobayashi, D., Kudo, N., Kawashima, Y.
Biological and Pharmaceutical Bulletin 35 ( 2 ) 184 - 191 2012.11
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pahrmaceutical Society of Japan
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Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats. Reviewed
Yamazaki, T., Wakabayashi, M., Ikeda, E., Tanaka, S., Sakamoto, T., Mitsumoto, A., Kudo, N., Kawashima, Y.
Biological and Pharmaceutical Bulletin 35 ( 9 ) 1505 - 1515 2012.06
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
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Differential Induction of Stearoyl-CoA Desaturase 1 and 2 genes by Fibrates in the Liver of Rats. Reviewed
Yamazaki, T., Okada, H., Sakamoto, T., Sunaga, K., Tsuda, T., Mitsumoto, A., Kudo, N. and Kawashima, Y.
Biological and Pharmaceutical Bulletin 35 ( 1 ) 116 - 120 2012.01
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
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Behavioral and biochemical characterization of rats treated chronically with thioacetamide: proposal of an animal model for hepatic encephalopathy associated with cirrhosis Reviewed
Kawai, H., Ishibashi, T., Kudo, N., Kawashima, Y., Mitsumoto, A.
Journal of Toxicological Sciences 37 1165 - 1175 2012
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Toxicology
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Impairment of heme biosynthesis induces short circadian period in body temperature rythms in mice.
Iwadate, R., Satoh, Y., Watanabe, Y., Kawai, H., Kudo, N., Kawashima, Y., Mitsumoto, A.
Am. J. Physiol. Regul. Integr. Comp, Physiol. 303 R8 - R18 2012
Language：English Publishing type：Research paper (scientific journal) Publisher：American Physiological Society
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Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice. Reviewed
Kudo, N., Yamazaki, T., Sakamoto, T., Sunaga, K., Tsuda, T., Mitsumoto, A. and Kawashima, Y.
Biological and Pharmaceutical Bulletin 34 ( 6 ) 856 - 864 2011.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
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Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats. Reviewed
Hirose, A., Yamazaki, T., Sakamoto, T., Sunaga, K., Tsuda, T., Mitsumoto, A., Kudo, N. and Kawashima, Y.
Journal of Pharmacological Sciences 116 362 - 372 2011
Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Pharmacological Society
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Pharamacokinetics of nateglinide enantiomers and their metabolites in Goto-Kakizaki rats, a model of type 2 diabetes mellitus Reviewed
Masafumi Tamura, Sachiko Shiba, Naomi Kudo, Yoichi Kawashima
Chirality 22 92 - 98 2010.02
Language：English Publishing type：Research paper (scientific journal)
経口投入病薬ナテグリニドおよびそのエナンチオマーについて、2型糖尿病モデルラットにおける動態解析を行った。ナテグリニドLエナンチオマーは、糖尿病ラットにおいて全身クリアランスおよび分布容積がナテグリニドよりも大きいことを明らかにした。
DOI： 10.1002
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Peroxisome proliferators attenuate free arachidonic acid pool in the kidney through inducing lysophospholipid acyltransferases Reviewed
Tohru Yamazaki, Akihiko Hiroshe, Takeshi Sakamoto, Mari Okazaki, Atsushi Mitsumoto, Naomi Kudo, Yoichi Kawashima
Journal of Pharmacologycal Sciences 111 201 - 210 2009.12
Language：English Publishing type：Research paper (scientific journal)
ペルオキシソーム増殖剤であるクロフィブリン酸、フタル酸エステルなどをラットに摂取させると、肝臓と腎臓において数種類のリゾリン脂質アシルトランスフェラーゼが誘導された。この誘導はmRNAレベルの上昇を友経っており、転写活性化によると考えられる。結果として腎臓における遊離アラキドン酸レベルの減少がおこるものと考えられる。
DOI： 10.1254
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Efficacy of urine bile acid as a non-invasive indicator of liver damage in rats Reviewed
Hiroshi Kawai, Naomi Kudo, Yoichi Kawasima, Atsushi Mitsumoto
The Journal of Toxicological Sciences 34 ( 1 ) 27 - 38 2009.01
Language：English Publishing type：Research paper (scientific journal)
thioacetamide で誘発した肝障害モデルラットにおいて、血清中の肝障害マーカーであるalkaline phosphatase などと尿中のビリルビン濃度に高い相関が認められることから、非侵襲のマーカーとして有用であることを見出した。
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Manifesatation of psychiatric behaviors in a mouse model of griseofulvin-induced hepatic injury Reviewed
Yoko Sato, Reiko Iwadate, Yukino Watanabe, Hiroshi Kawai, Naomi Kudo, Yoichi Kawasima, Atsushi Mitsumoto
The Journal of Toxicological Sciences 33 ( 5 ) 599 - 608 2008.12
Language：English Publishing type：Research paper (scientific journal)
Griseofulvinを摂取させて誘発した肝ポルフィリン症モデルマウスにおいて、用量および摂取期間依存的な不安症やうつ状態が認められたことから、ヒトのポルフィリン症における精神神経症状の発症メカニズム解明のための有益なツールとなることを示した。
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Effects of supplemented diacylglycerol rich in docosahexaenoic acid on serum triacylglycerol in a diet-induced hyperlipidemic model of rats are essentially equivalent to those of triacylglycerol rich in docosahexaenoic acid. Reviewed
1. Tamai, T., Murota, I., Maruyama, K., Baba, T., Toyama, T., Watanabe, N., Kudo, N. and Kawashima, Y.
Biol Pharm Bull. 30 ( 12 ) 2381 - 2388 2007.12
Language：English Publishing type：Research paper (scientific journal)
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Tissue distribution and subcellular distribution of peprfluorooctanoic acid at low dose are different from those at high dose in rats."jointly worked" Reviewed
Kudo N.,Sakai A.,Mitsumoto A.,Hibino Y.,Tsuda T.,Kawashima, Y.
Biol. Pharm. Bull. 30 ( 8 ) 1535 - 1540 2007.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Reducing effect of matrix metalloproteinase inhibitors on serum triacylglycerol in streptozotocin-induced diabetic rats and Zucker fa/fa rats."jointly worked" Reviewed
Morikawa T.,Kudo N.,Toyama T.,Kawashima Y.
Biol. Pharm. Bull. 30 ( 8 ) 1461 - 1467 2007.08
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Effects of pioglitazone on stearoyl-CoA desaturase in obese Zucker fa/fa rats."jointly worked" Reviewed
Toyama T.,Kudo N.,Hibino Y.,Mitsumoto A.,Nishikawa M.,Kawashima K.
J. Pharm. Sci. 104 ( 2 ) 137 - 145 2007.06
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats."jointly worked" Reviewed
Toyama T.,Kudo N.,Mitsumoto A.,Hibino Y.,Tsuda, T.
J. Pharm. Sci. 103 ( 4 ) 383 - 390 2007.04
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Rat organic anion transporter 3 and organic anion transporting polypeptide 1 mediate perfluorooctanoic acid transport"jointly worked" Reviewed
Katakura M.,Kudo N.,Tsuda T.,Hibino Y.,Mitsumoto A.,Kawashima, Y.
J. Health Science 53 ( 1 ) 77 - 83 2007.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice:In relation to induction of hepatomegaly, peroxisomal .-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase."jointly worked" Reviewed
Kudo N.,Suzuki- Nakajima E.,Mitsumoto A.,Kawashima Y.
Biol. Pharm. Bull. 29 ( 9 ) 1952 - 1957 2006.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effect of 8-2 fluorotelomer alcohol on oleic acid formation in the liver of rats."jointly worked" Reviewed
Iwase Y.,Kudo N.,Toyama T.,Tamura M.,Mitsumoto A.,Kawashima Y.
Biol. Pharm. Bull. 28 ( 8 ) 1740 - 1746 2006.08
Language：English Publishing type：Research paper (scientific journal)
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Studies on the mechanisms for the accumulation of perfluorinated fatty acids and related compounds Invited
Kudo, N
22 21 - 26 2006.08
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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Temperature rhythm reentrains faster than locomotor rhythm after a light phase shift."jointly worked" Reviewed
Sato Y.,Kawai H.,Kudo N.,Kawashima Y.,Mitsumoto, A.
Physiology and Behavior 88 ( 4-5 ) 404 - 410 2006.07
Language：English Publishing type：Research paper (scientific journal)
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Time-restricted feeding entrains daily rhythms of energy metabolism in mice."jointly worked" Reviewed
Sato Y.,Kawai H.,Kudo N.,Kawashima Y.,Mitsumoto A.
Am. J. Physiol., Regul., Integr., Comp. Physiol. 290 ( 5 ) 1276 - 1283 2006.02
Language：English Publishing type：Research paper (scientific journal)
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Induction of hepatic peroxisome proliferation by 8-2 telomer alcohol feeding in mice: Formation of perfluorooctanoic acid."jointly worked" Reviewed
Kudo N.,Iwase Y.,Okayachi H.,Yamakawa Y.
Toxicol. Sci. 86 ( 2 ) 231 - 238 2005.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Regulation of palmitoyl-CoA chain elongation by clofibric acid in the liver of Zucker fa/fa rats."jointly worked" Reviewed
Toyama T.,Kudo N.,Mitsumoto A.,Kawashima Y.
Lipids 40 ( 5 ) 463 - 470 2005.05
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Effects of perfluorocarboxylic acids on the activities of acyl-CoA elongations in vivo and in vitro."jointly worked" Reviewed
ToyamaT.,Kudo N.,Mitsumoto A.,Kawashima Y.
Chemico-Biol. Interact. 150 ( 2 ) 189 - 198 2004.11
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Effects of dehydroepiandrosterone on oleic acid accumulation in the liver of rats.jointly worked" Reviewed
Imai K.,Kudo N.,Koyama M.,Kawashima Y.
Biochem. Pharmacol. 65 ( 10 ) 1583 - 1591 2003.05
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Regulation by carbohydrate and clofibric acid of palmitoyl-CoA chain elongation in the liver of rats."jointly worked" Reviewed
Kudo N.,Toyama T.,Mitsumoto A.,Kawashima Y.
Lipids 38 ( 5 ) 531 - 537 2003.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Sex hormone regulation of rOAT3 expression in rat kidney."jointly worked" Reviewed
Katakura M.,Kudo N.,Okazaki M.,Hibino Y.
J. Health Sci. 49 233 - 238 2003.05
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length."jointly worked" Reviewed
Ohmori K.,Kudo N.,Katayama K.,Kawashima Y.
Toxicology 184 135 - 140 2003.03
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Induction by perfluorinated fatty acids with different carbon chain length of triglyceride accumulation in the liver of rats."jointly worked" Reviewed
Kudo N.,Kawashima Y.
Biol. Pharm. Bull. 26 47 - 51 2003.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Sex hormone-regulated renal transport of perfluorooctanoic acid. Reviewed
Naomi Kudo, Masanori Katakura, Yoshinori Sato, Yoichi Kawashima
Chemico-Biological Interactions 131 301 - 316 2002.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effects of dehydroepiandrosterone on oleic acid formation in the liver of rats, mice and guinea pigs. Reviewed
Koichi Imai, Naomi Kudo, Matajirou Koyama, Akira Shirahata , Yoichi Kawashima
Japanese Journal of Pharmacology 86 437 - 447 2001.11
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Comparison of the elimination between perfluorinated fatty acids with different carbon chain length in rats. Reviewed
Naomi Kudo, Erika Suzuki, Masanori Katakura, Kohtaro Ohmori, Rie Noshiro, Yoichi Kawashima
Chemico-Biological Interactions 134 203 - 216 2001.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effects of perfluorooctanoic acid on the synthesis of phospholipids in the liver of mice fed a dietary soybean oil, perilla oil or fish oil. Reviewed
Naomi Kudo, Yoichi Kawashima
Journal of Health Science 47 168 - 174 2001.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Metabolic alterations by clofibric acid in the formation of molecular species of phosphatidylcholine in the liver of rats. Reviewed
Hiroki Mizuguchi, Naomi Kudo, Yoichi Kawashima
Biochemical Pharmacology 62 853 - 861 2001.04
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Modification of carbon tetrachloride-induced hepatotoxicity by clofibric acid in rats. Reviewed
Yoshihiro Yamakawa, H Doi, K Kubota, H Okayachi, Naomi Kudo, Yoichi Kawashima
Journal of Health Science 46 131 - 142 2000.08
Language：English Publishing type：Research paper (scientific journal)
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Induction by perfluorinated fatty acids with different carbon chain length of peroxisomal b-oxidation in the liver of rats. Reviewed
Naomi Kudo, Naoki bandai, Erika Suzuki, Masanori Karakura , Yoichi Kawashima
Chemico-Biological Interactions 124 119 - 132 2000.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Alterations by perfluorooctanoic acid of glycerolipid metabolism in rat liver. Reviewed
Naomi Kudo, Hiroki Mizuguchi, Yoichi Kawashima
Chemico-Biological Interactions 118 69 - 83 1999.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effects of tiadenol and di(2-ethylhexyl)phtalate on the metabolism of phosphatidylcholine and phosphatidylethanolamine in the liver of rats. Reviewed
Hiroki Mizuguchi, Naomi Kudo, Takeshi Ohya, Yoichi Kawashima
Biochmical Pharmacology 57 869 - 876 1999.11
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Phosphorylation of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5’AMP-activated protein kinase. Reviewed
Jason Dyck, Naomi Kudo, Amy Barr, P Davies, Graham Hardie, Gary Lopaschuk
European Journal of Biochemistry 262 184 - 190 1999.09
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Increase in hepatic content of oleic acid induced by dehydroepiandrosterone in the rat. Reviewed
Koichi Imai, Matajiroh Koyama, Naomi Kudo, Akira Shirahata, Yoichi Kawashima
Biochemical Pharmacology 58 925 - 933 1999.08
Language：English Publishing type：Research paper (scientific journal)
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Effects of fish oil feeding alone in combination with clofibric acid on serum levels of triacylglycerol and cholesterol in rats. Reviewed
Naomi Kudo, Yoichi Kwashima
Journl of Health Science 45 237 - 243 1999.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Accumulation of various species of N-acylethanolamine including N-arachidonoylethanolamine (anandamide), an endogenous cannabinoid receptor ligand, in cadmium chloride-administered rat testis. Reviewed
Sachiko Kondo, Takayuki Sugiura, Hiroko Kodaka, Naomi Kudo, Keizo Waku
Archives of Biochemistry and Biophysiology 354 303 - 310 1998.08
Language：English Publishing type：Research paper (scientific journal)
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Quantification of perfluorocarboxylic acids by gas-liquid chromatography in rat tissues. Reviewed
Naomi Kudo, Naoki Bandai, Yoichi Kawashima
Toxicology Letters 99 183 - 190 1998.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Determination by high-performance liquid chromatography of perfluorinated carboxylic acids in biological samples. Reviewed
Takeshi Ohya, Naomi Kudo, Erika Suzuki, Yoichi Kawashima
Journal of Chrimatography B 720 1 - 7 1998.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice. Reviewed
Naomi Kudo, Yoichi Kawashima
Toxiclogy and Applied Pharmacology 145 285 - 293 1997.11
Language：English Publishing type：Research paper (scientific journal)
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Characterization of 5’AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Reviewed
Naomi Kudo, John Gillespie, Lina Kung, Rick Shults, Sandy Clanachan, Gary Lopaschuk
Biochimica et Biophysica Acta 1301 67 - 75 1996.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Biphasic effect of cadmium ions on the production of leukotriene B4 in rabbit alveolar macrophages. Reviewed
Naomi Kudo, Yasuhito Nakagawa, Keizo Waku
Archives of Toxicology 70 801 - 808 1996.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Role of stearyl-CoA desaturase in the modification of acyl composition of hepatic phosphatidylcholine by peroxisome proliferators. Reviewed
Hiroki Mizuguchi, Naomi Kudo, Yoichi Kawashima
Biological and Pharmacological Bulletin 19 1556 - 1559 1996.08
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Cadmium suppresses delta 9 desaturase activity in rat hepatocytes. Reviewed
Naomi Kudo, Keizo Waku
Toxicology 114 101 - 111 1996.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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High rate of fatty acid oxidation in reperfused ischemic heart can be explained by phosphorylation and activation of 5'AMP-activated protein kinase. Reviewed
Naomi Kudo, John Gillespie, Bin Liu, Sandy Clanachan, Rick Schults, Gary Lopascuk
Circulation 98 I387 - I387 1995.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Heart contains an active 5’AMP-activatedprotein kinase that is involved in the regulation of fatty acid oxidation. Reviewed
Naomi Kudo, Lina Kung, Lee Witters, Grahame Hardie, Gary Lopasuchuk
Circulation 98 I771 - I771 1995.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Coenzyme A dependent modification of fatty acyl chains of rat liver membrane phospholipids: Possible involvement of ATP-dependent acyl-CoA synthesis. Reviewed
TakayukiSugiura, Naomi Kudo, Takayuki Ojima, Sachiko Koudo, Atsushi Yamashita, Keizo Waku
Journal of Lipid Research 36 440 - 450 1995.11
Language：English Publishing type：Research paper (scientific journal)
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Platelet-activating factor and its structural analogues in the earthworm Eisenia foetida. Reviewed
Takayuki Sugiura, Atsushi Yamashita, Teruo Fukuda, Nen-nen Chen, Tatuya Miyamoto, Seishi Kishimoto, Keizo Waku, T Tanaka, H Tsukatani, Akira Tokumura
Biochimica Biophysica Acta 1258 19 - 28 1995.10
Language：English Publishing type：Research paper (scientific journal)
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Coenzyme A dependent cleavage of membrane phospholipids in several rat tissues: ATP-independent acyl-CoA synthesis and the generation of lysophospholipids. Reviewed
Takayuki Sugiura, Naomi Kudo, Takayuki Ojima, Kiyoko Mabuchi-Ito, Atsushi Yamashita, Keizo Waku
Biochimca Biophysica Acta 1255 167 - 176 1995.07
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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High rate of fatty acid oxidation during reperfusion of ischemic hearts can be explained by a decrease in malonyl-CoA levels due to an increase in 5’AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. Reviewed
Naomi Kudo, Amy Barr, Rick Barr, Snehal Desai, Gary Lopasuchuk
Journal of Biological Chemistry 270 17513 - 17520 1995.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Mercuric chloride induces the production of leukotriene B4 in rabbit alveolar macrophages. Reviewed
Naomi Kudo, Keizo Waku
Archives of Toxicology 68 179 - 186 1994.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Platelet-activating factor and related lipid molecules in invertebrate. Reviewed
Takayuki Sugiura, Atsushi Yamashita, Naomi Kudo, Keizo Waku
Journal of Lipid Medators and Cell Signaling 10 185 - 186 1994.06
Language：English Publishing type：Research paper (scientific journal)
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Inhibition of the liberation of arachidonic acid by cadmium ions in rabbit alveolar macrophages. Reviewed
Naomi Kudo, Yasuhito Nakagawa, Keizo Waku
Archives of Toxicology 66 131 - 146 1992.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Prevention by zinc of cadmium inhibition of stearoyl-CoA desaturase in rat liver. Reviewed
Naomi Kudo, Yasuhito Nakagawa, Keizo Waku , Yoichi Kawashima ,Hiroshi Kozuka
Toxicology 68 133 - 142 1991.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effects of zinc deficiency on the fatty acid composition and metabolism in rats fed a fat-free diet. Reviewed
Naomi Kudo, Yasuhito Nakagawa, Keizo Waku
Biological Trace Element Research 24 49 - 60 1990.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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The effect of cadmium on the composition and metabolism of hepatic fatty acid in zinc-adequate and zinc-deficient rats. Reviewed
Naomi Kudo, Yasuhito Nakagawa, Keizo Waku
Toxicology Letters 50 203 - 212 1990.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Protection against cadmium toxicity by zinc: Decrease in the high-molecular protein fraction in rat liver and kidney on Zn pretreatment. Reviewed
Naomi Kudo, Shohei Yamashina, Keizo Waku
Toxicology 40 267 - 277 1986.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)