Papers - TODO Hiroaki
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In Silico Estimation of Skin Concentration of Dermally Metabolized Chemicals Reviewed
Tomomi Hatanaka, Saki Yamamoto, Mayuko Kamei, Wesam R Kadhum, Hiroaki Todo and Kenji Sugibayashi
International Journal of Pharmaceutical Sciences and Developmental Research 2017.01
Language：English Publishing type：Research paper (scientific journal)
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A useful technique using imaging mass spectrometry for detecting the skin distribution of topically applied lidocaine Reviewed
Shosho Kijima, Hiroaki Todo, Yumi Matsumoto, Ryosuke Masaki, Wesam R. Kadhum, Kenji Sugibayashi
Journal of Drug Delivery Science and Technology 33 157 - 163 2016.06
Language：English Publishing type：Research paper (scientific journal)
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Effect of Combination of Low-Frequency Sonophoresis or Electroporation with Iontophoresis on the Mannitol Flux or Electroosmosis through Excised Skin Reviewed
Tokumoto S, Higo N, Todo H, Sugibayashi K
Biol Pharm Bull 2016.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Risk assessment of skin lightening cosmetics containing hydroquinone., Regul Toxicol Pharmacol. Reviewed
Matsumoto M, Todo H, Akiyama T, Hirata-Koizumi M, Sugibayashi K, Ikarashi Y, Ono A, Hirose A, Yokoyama K.
Regul Toxicol Pharmacol. 2016.01
Language：English Publishing type：Research paper (scientific journal)
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Effect of Esters on the Permeation of Chemicals with Different Polarities through Synthetic Artificial Membranes Using a High-Throughput Diffusion Cell Array. Reviewed
Uchida T, Nishioka K, Motoki A, Yakumaru M, Sano T, Todo H, Sugibayashi K
Chem Pharm Bull (Tokyo) 2016.01
Language：English Publishing type：Research paper (scientific journal)
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Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals Reviewed
Mohd F, Todo H, Yoshimoto M, Yusuf E, Sugibayashi K
Pharmaceutics 2016.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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In Vitro Permeation and Skin Retention of α-Mangostin Proniosome, Reviewed
Chin GS, Todo H, Kadhum WR, Hamid MA, Sugibayashi K
Chem Pharm Bull (Tokyo) 2016.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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A Novel Chemical Enhancer Approach for Transdermal Drug Delivery with C17-Monoglycerol Ester Liquid Crystal-forming Lipid Reviewed
Kadhum WR, Sekiguchi S, Hijikuro I, Todo H, Sugibayashi K.
J Oleo Sci 2016.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Evaluation of a Silicone Membrane as an Alternative to Human Skin for Determining Skin Permeation Parameters of Chemical Compounds Reviewed
Uchida T, Yakumaru M, Nishioka K, Higashi Y, Sano T, Todo H, Sugibayashi K
Chem Pharm Bull (Tokyo) 2016.01
Language：English Publishing type：Research paper (scientific journal)
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Usefulness of liquid-crystal oral formulations to enhance the bioavailability and skin tissue targeting of p-amino benzoic acid as a model compound Reviewed
Kadhum WR, Oshizaka T, Ichiro H, Todo H, Sugibayashi K
Eur J Pharm Sci 2016.01
Language：English Publishing type：Research paper (scientific journal)
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In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals. Reviewed
Tomomi Hatanaka, Shun Yoshida, Wesam R Kadhum, Hiroaki Todo, Kenji Sugibayashi
Pharmaceutical research 32 ( 12 ) 3965 - 3974 2015.12
Language：English Publishing type：Research paper (scientific journal)
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A new approach for evaluating cellular damage by measuring calcium level with Fura-2 acetoxymethyl ester (Fura-2-AM) Reviewed
Wesam R. Kadhum, Manami Mitsuyama, Toru Tanaka, Hiroaki Todo, Kazuhiko, Juni, Kenji Sugibayashi,
Alternatives to Animal Testing and EXperimentation 2015.10
Language：English Publishing type：Research paper (scientific journal)
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In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals Reviewed
Hatanaka T, Yoshida S, Kadhum WR, Todo H, Sugibayashi K
Pharm Res 2015.07
Language：English Publishing type：Research paper (scientific journal)
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Prediction of skin permeation by chemical compounds using the artificial membrane, Strat-M™. Reviewed
Takashi Uchida, Wesam R Kadhum, Sayumi Kanai, Hiroaki Todo, Takeshi Oshizaka, Kenji Sugibayashi
European journal of pharmaceutical sciences 67 113 - 118 2015.01
Language：English Publishing type：Research paper (scientific journal)
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Determination of permeation pathways of clindamycin phosphate into the skin, Reviewed
Fadli A., Mohammad Nizam A. G.,Ibrahim A., Kavitha M., Jiyauddin K., Samer, A. D., S. Budiasih, M. Kaleemullah ,Jawad A., Rasha S., Todo H., Sugibayashi K., Eddy Y.
Am. J. PharmTech. Res., 2015.01
Language：English Publishing type：Research paper (scientific journal)
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Potential of imaging analysis in establishing skin concentration-distance profiles for topically applied FITC-dextran 4 kDa Reviewed
Shosho Kijima, Ryosuke Masaki, Wesam R. Kadhum, Hiroaki Todo, Tomomi Hatanaka, Kenji Sugibayashi,
ADMET and DMPK 2015.01
Language：English Publishing type：Research paper (scientific journal)
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Molecular mechanisms of action of different concentrations of ethanol in water on ordered structures of intercellular lipids and soft keratin in the stratum corneum Reviewed
1. D. Horita, H., I. Hatta, M Yoshimoto, Y. Kitao, H. Todo, K. Sugibayashi
BBA – Biomembranes 2015
Language：English Publishing type：Research paper (scientific journal)
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Formulation of Tetracycline nano-emulsion Reviewed
Fadli A., Nizam A. G., Ibrahim A. , Nurulnadiah A. K., Jiyauddin K., Samer A. D., S. Budiasih, M. Kaleemullah, Jawad A., Rasha S., Todo H., Sugibayashi K. and Eddy Y.
WJPR 2015
Language：English Publishing type：Research paper (scientific journal)
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Determination of permeation of pathway of Gentamicin into pig’s ear skin Reviewed
Fadli A., Jiyauddin K., Siti Nur S. J., Samer A. D., S. Budiasih, Jawad A., M. Kaleemullah, Rasha S., Mohammad Nizam A. G., Ibrahim A., Todo H., Sugibayashi K. and Eddy Y.
IRJP 2015
Language：English Publishing type：Research paper (scientific journal)
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Estimation of skin concentrations of topically applied lidocaine at each depth profile.
Oshizaka Takeshi, Kikuchi Keisuke, Kadhum Wesam R, Todo Hiroaki, Hatanaka Tomomi, Wierzba Konstanty, Sugibayashi Kenji
Int J Pharm 475 ( 1-2 ) 292 - 297 2014.11
Language：English Publishing type：Research paper (scientific journal)
Skin concentrations of topically administered compounds need to be considered in order to evaluate their efficacies and toxicities. This study investigated the relationship between the skin permeation and concentrations of compounds, and also predicted the skin concentrations of these compounds using their permeation parameters. Full-thickness skin or stripped skin from pig ears was set on a vertical-type diffusion cell, and lidocaine (LID) solution was applied to the stratum corneum (SC) in order to determine in vitro skin permeability. Permeation parameters were obtained based on Fick's second law of diffusion. LID concentrations at each depth of the SC were measured using tape-stripping. Concentration-depth profiles were obtained from viable epidermis and dermis (VED) by analyzing horizontal sections. The corresponding skin concentration at each depth was calculated based on Fick's law using permeation parameters and then compared with the observed value. The steady state LID concentrations decreased linearly as the site became deeper in SC or VED. The calculated concentration-depth profiles of the SC and VED were almost identical to the observed profiles. The compound concentration at each depth could be easily predicted in the skin using diffusion equations and skin permeation data. Thus, this method was considered to be useful for promoting the efficient preparation of topically applied drugs and cosmetics.