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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Title |
Professor |
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External Link |
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KUDO Naomi
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Research Areas 【 display / non-display 】
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Environmental Science/Agriculture Science / Radiation influence
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Life Science / Pharmaceutical hygiene and biochemistry
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Environmental Science/Agriculture Science / Chemical substance influence on environment
From School 【 display / non-display 】
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Hokkaido University Faculty of Pharmaceutical Science Graduated
- 1983.03
Country：Japan
Studying abroad experiences 【 display / non-display 】
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1994.05 - 1995.04 University of Alberta Post Doctoral Fellow
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Professor
2011.04
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Associate Professor
2007.04 - 2011.03
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Josai University Faculty of Pharmaceutical Sciences Associate Professor (as old post name)
2006.04 - 2007.03
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Josai University Faculty of Pharmaceutical Sciences Lecturer
2003.04 - 2006.03
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Josai University Faculty of Pharmaceutical Sciences Research Assistant
1996.04 - 2003.03
External Career 【 display / non-display 】
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カナダアルバータ州立大学医学部 博士研究員
1994.05 - 1995.04
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帝京大学薬学部 助手
1986.04 - 1996.03
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帝京大学薬学部 教務職員
1983.04 - 1986.03
Professional Memberships 【 display / non-display 】
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Japan Radioisotope Association
2007.07
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The Japanese Society of Toxicology
2005.01
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日本食品衛生学会
2003.04
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日本中毒学会
2002.04
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日本脂質栄養学会
1990.04
Qualification Acquired 【 display / non-display 】
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Pharmacist
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Chief Person of Radiation Handling （first and second kind）
Papers 【 display / non-display 】
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Reduction in Secretion of Very Low Density Lipoprotein–Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia Reviewed International journal
Yoichi Kawashima, Yoshihiro Eguchi, Tohru Yamazaki, Minako Karahashi, Hiroshi Kawai, and Naomi Kudo
Journal of Pharmacology and Experimental Therapeutics 366 ( 7 ) 194 - 204 2018.07
Language：English Publishing type：Research paper (scientific journal) Publisher：The American Society of Pharmacology and Experimental Therapeutics
Matrix metalloproteinase inhibitors (MMPIs) reduced serum triacylglycerol (TAG) levels in streptozotocin-induced diabetic rats and Zucker fa/fa rats in our previous study. However, the mechanisms underlying TAG reduction by MMPIs remain unclear. The present study aimed to elucidate the mechanism by which F81-1144b, an MMPI, lowers serum TAG levels in an animal model of high-sucrose diet (HSD)-induced hypertriglyceridemia. F81-1144b was repeatedly administered to rats fed HSD, and its effects were evaluated on TAG levels in serum and the liver, very low density lipoprotein (VLDL) secretion, de novo fatty acid (FA) synthesis in the liver, and the expression of genes regulating the metabolism of FA, TAG, and VLDL in the liver and serum. F81-1144b lowered TAG levels in serum and the liver, VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose. F81-1144b suppressed the expression of genes related to the de novo synthesis of FA and TAG, key proteins (lipin 1 and apolipoprotein CIII) responsible for VLDL metabolism, and sterol regulatory element-binding protein-1c and carbohydrate response element-binding protein. F81-1144b little affected the expression of genes related directly to the degradation of TAG or FA, but it upregulated that of gene for uncoupling protein 2 in the liver. These results suggest that MMPIs are a novel type of therapeutic agent for the treatment of hypertriglyceridemia, because the metabolic effects of F81-1144b expected from changes in the expression of genes regulating lipid metabolism would alter metabolism differently from those induced by fibrates, niacin, or n-3 FAs.
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Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats Reviewed International journal
Hiroshi Kawai, Natsumi Kodaira, Chika Tanaka, Takuya Ishibashi, Naomi Kudo, YoichiKawashima, Atsushi Mitsumoto
Journal of Circadian Rhythms 16 5 2018.05
Language：English Publishing type：Research paper (scientific journal) Publisher：Bio Med Central
The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility and increased climbing in the FST. The plasma concentrations of imipramine and its metabolite, desipramine, were slightly higher in the morning than in the evening, which might explain the dosing time-dependent action of imipramine. Next, we analyzed the effect of chronic imipramine treatment. Rats received imipramine in the morning or in the evening for 2 weeks. The morning treatment resulted in larger effects in the FST than the evening treatment, and was effective at a dose that was ineffective when administered acutely. The levels of brain α-adrenergic receptors tended to decrease after chronic imipramine treatment. Imipramine might interact with noradrenergic neurons, and this interaction might chronically alter receptor expression. This alteration seemed greater in the morning than in the evening, which might explain the dosing time-dependent action of imipramine.
DOI： 10.5334/jcr.156
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Hiroshi Kawai, Megumi Machida, Takuya Ishibashi, Naomi Kudo, Yoichi Ka ...
Biological and Pharmaceutical Bulletin 41 ( 2 ) 213 - 219 2018.02
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Sciety of Japan
Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran in the morning (8:00 a.m.; zeitgeber time [ZT]1) or in the evening (8:00 p.m.; ZT13) were analyzed in a forced swim test (FST). At ZT1, the rats’ immobility was reduced and the swimming was increased, whereas at ZT13, their climbing was increased. These results suggest that the serotonergic and noradrenergic systems are preferentially affected at ZT1 and ZT13, respectively by milnacipran. We analyzed the plasma and brain levels of milnacipran after administration, and there were no differences between ZT1 and ZT13. The circadian rhythm of monoamine neurotransmitters was analyzed in several brain regions. The serotonin turnover showed rhythms with a peak during ZT18–ZT22 in hippocampus. The noradrenaline turnover showed rhythms with a peak during ZT22–ZT2. There was a difference of approx. 4 h between the serotonergic and noradrenergic systems. This time difference might be one of the factors that affect the action of milnacipran and contribute to the dosing time-dependent behavioral pattern in the FST.
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Hiroshi KAWAI, Jin INABE, Takuya ISHIBASHI, Naomi KUDO, Yoichi KAWASHI ...
Biomedical Research 39 ( 1 ) 47 - 55 2018.02
Language：English Publishing type：Research paper (scientific journal) Publisher：Biomedical Research Press
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Disposition of perfluorododecanoic acid in male rats after an oral administration Reviewed
Fundamental Toxicological Sciences 4 ( 4 ) 179 - 186 2017.07
Language：English Publishing type：Research paper (scientific journal) Publisher：日本毒性学会
DOI： 10.2131/fts.4.179
Books and Other Publications 【 display / non-display 】
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Pharmaceutical Health Science
Satosi Asano, Sumiko Abe, Fuminori Ohtsuka, Yoichi Kawashima, Naomi Kudo, Akinori Sugiyama, Yasuhito Nakagawa, Atsushi Mitsumoto（ Role： Joint author , Part 5: Toxicology）
Kyoto Hirokawa 2016.09 （ ISBN:9784906992881 ）
Language：Japanese Book type：Scholarly book
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Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
Christopher Lau, Sonia Dagnino, Naomi Kudo, et al. （ Role： Joint author , Metabolism and Pharmacokinetics）
Humana Press 2015 （ ISBN:978-3-319-15517-3 ）
Language：English Book type：Scholarly book
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Radiochemistry and Radioprmaceuticals
Naomi Kudo（ Role： Joint author）
Nankodo 2011.03
Language：Japanese Book type：Textbook, survey, introduction
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Pharmaceutical Sciences
Masao Sato et al.（ Role： Joint author）
Nankodo 2011.03
Language：Japanese Book type：Textbook, survey, introduction
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環境・健康科学辞典(共著)
工藤なをみ（ Role： Joint author）
丸善 日本薬学会編 2005.01
Language：Japanese Book type：Dictionary, encyclopedia
Misc 【 display / non-display 】
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Study on bioaccumulation and safety estimation of fruorinated fatty acids
Naomi Kudo
Advances in Pharmaceutical Sciences 22 21 - 26 2006.03
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：The Research Foundation for Pharmaceutical Sciences
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Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals.
Kudo, N. and Kawashima, Y.
J Toxicol Sci. 28 ( 2 ) 49 - 57 2003.05
Authorship：Lead author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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不飽和脂肪酸の代謝とその調節機構
工藤なをみ、川嶋洋一
Radioisotopes 45 601 - 602 1996.06
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本アイソトープ協会
Presentations 【 display / non-display 】
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Tokicokinetics of PFAA International conference
Naomi Kudo
PFAA Mode of Action United States of Environmental Protection Agency
Event date： 2007.08
Language：English Presentation type：Oral presentation (general)
Venue：Research Triangle Park, NC, USA
米国環境保護局の招待により、ペルフルオロアルキル化合物の安全性評価に関する最新の情報の発表と意見交換を行った。
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Comparative toxicokinetics among PFAA and related chemistries International conference
Naomi Kudo
Perfluoroalkyl acids and related chemistries: Tokicokinetics and mode of action Workshop Society of Toxicology, USA
Event date： 2007.02
Language：English Presentation type：Oral presentation (general)
Venue：Arlington, VA, USA
米国毒性学会の招待により、ペルフルオロアルキル化合物の体内動態に関する招待講演を行った。
Scientific Research Funds Acquisition Results 【 display / non-display 】
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ペルフルオロ化合物の生体残留性の検討と排泄促進剤の探索
2007.04 - 2010.03
科学研究費補助金 基盤研究(C)
ペルフルオロ化合物の生体残留性の検討と排泄促進剤の探索
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フッ素系界面活性剤は代謝により活性化される
2006.04 - 2009.03
科学研究費補助金 基盤研究(C)
フッ素系界面活性剤は代謝により活性化される
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ペルフルオロアルキルテロマーアルコールの体内動態の解明とヒトにおける残存性の評価
2003.04 - 2006.03
科学研究費補助金 基盤研究(C)
ペルフルオロアルキルテロマーアルコールの体内動態の解明とヒトにおける残存性の評価
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培養細胞系を用いた化学物質の吸収、排泄機構系の確立と安全性評価に関する研究
2000.04 - 2003.03
科学研究費補助金 基盤研究(C)
培養細胞系を用いた化学物質の吸収、排泄機構系の確立と安全性評価に関する研究
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フッ素化脂肪酸化合物を認識する新規細胞膜輸送体の検索とそのクローニング
1997.04 - 1999.03
科学研究費補助金 奨励研究(A)
フッ素化脂肪酸化合物を認識する新規細胞膜輸送隊の検索
Other External Funds 【 display / non-display 】
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フッ素系界面活性剤の生体内蓄積機構と安全性評価に関する研究
2002.04 - 2003.03
民間財団等 薬学研究奨励財団
Grant type：Competitive
フッ素系界面活性剤の生体内蓄積機構と安全性評価に関する研究
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難代謝性フッ素化脂肪酸の生体作用メカニズムの解明
1999.04 - 2000.03
民間財団等 武田科学振興財団
Grant type：Competitive
難代謝性フッ素化脂肪酸の生体作用メカニズムの解明
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化学物質により誘発される脂肪肝の魚油摂取による改善の試み
1997.04 - 1998.03
民間財団等 医薬資源研究振興会
Grant type：Competitive
化学物質により誘発される脂肪肝の魚油摂取による改善の試み
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ペルフルオロカルボン酸の炭素鎖長の違いによる体内動態と肝特異性ペルオキシソーム増殖作用の解析
1996.04 - 1997.03
民間財団等 島原科学振興会研究助成金
Grant type：Competitive
ペルフルオロカルボン酸の炭素鎖長の違いによる体内動態と肝特異性ペルオキシソーム増殖作用の解析
Past of Cooperative Research 【 display / non-display 】
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文部科学省科学研究補助金基盤研究(C)
2000.04 - 2003.03
民間企業 Collaboration in College
文部科学省科学研究補助金基盤研究(C)薬物による不飽和脂肪酸合成制御の試みにおいて、研究代表者 川嶋洋一教授（本学）の研究分担者として研究に参画した。
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文部省科学研究補助金基盤研究(C)
1997.04 - 2000.03
Collaboration in College
文部省科学研究補助金基盤研究(C)ぺるふるおろ化合物の生体残留性の検討と再説促進剤の探索」において、研究代表者川嶋洋一 教授（本学）の分担研究者として研究を行った。
Committee Memberships 【 display / non-display 】
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日本薬学会 代議員
2013.02
Committee type：Academic society
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日本薬学会 薬学教育モデルコアカリキュラム改訂に関する調査研究チーム委員
2012.09 - 2013.09
Committee type：Academic society
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日本薬学会 関東支部幹事
2008.02
Committee type：Academic society
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日本薬学会 ファルマシア地区通信委員
2005.12
Committee type：Academic society
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日本薬学会 ホームページ・薬学用語辞典小委員会委員
2005.04 - 2007.03
Committee type：Academic society
Social Activities 【 display / non-display 】
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厚生労働省薬事・食品衛生審議会臨時委員（動物用医薬品等部会）
厚生労働省薬事・食品衛生審議会 2017.01
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厚生労働省薬事・食品衛生審議会専門委員（動物用医薬品残留問題調査会）
2015.09
動物用医薬品残留問題調査会
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日本中央競馬会禁止薬物再検査制度立会人
2003.04