Papers - KIMURA Mitsutoshi
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Role of Hepatocyte Growth Regulators in Liver Regeneration Invited Reviewed
Mitsutoshi Kimura, Hajime Moteki and Masahiko Ogihara
Cells 12 ( 2 ) 208 - 220 2023.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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健康サポート薬局における健康相談会の相談・体験コーナー参加者に対する興味・関心度に関する調査 Reviewed
茂木 肇，山本雅人，臼井達洋，木村光利
日本地域薬局薬学会誌 12 122 - 132 2024.12
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)
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Phenylephrine enhances the mitogenic effect of S-allyl-L-cysteine on primary cultured hepatocytes through protein kinase C-induced B-Raf phosphorylation. Reviewed
H. Moteki, M. Ogihara, M. Kimura,
Biol. Pharm. Bull. 47 1565 - 1574 2024
Authorship：Last author Language：English
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Cell proliferation effects of S-allyl-L-cysteine are associated with phosphorylation of janus kinase 2, insulin-like growth factor type-I receptor tyrosine kinase, and extracellular signal-regulated kinase 2 in primary cultures of adult rat hepatocytes Reviewed
Hajime Moteki, Masahiko Ogihara, Mitsutoshi Kimura
Eur J Pharmacol. 927 175067 2022.07
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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S-Allyl-L-cysteine Promotes Cell Proliferation by Stimulating Growth Hormone Receptor/Janus Kinase 2/Phospholipase C Pathways and Promoting Insulin-Like Growth Factor Type-I Secretion in Primary Cultures of Adult Rat Hepatocytes Reviewed
Hajime Moteki, Masahiko Ogihara, and Mitsutoshi Kimura
Biol. Pharm. Bull. 45 ( 5 ) 625 - 634 2022.05
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation. Reviewed
Mitsutoshi Kimura, Hajime Moteki, and Masahiko Ogihara
Eur J Pharmacol. 745 223 - 233 2014.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Inhibitory effects of dexamethasone on hepatocyte growth factor-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Reviewed
Mitsutoshi Kimura, Hajime Moteki, and Masahiko Ogihara
J Pharmacol. Sci. 115 ( 3 ) 390 - 398 2011.03
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70% partially hepatectomized rats, in vivo. Reviewed
Mitsutoshi Kimura, Makiko Watanabe, Naoto Ishibashi, Shingo Yanagida, and Masahiko Ogihara
Eur J Pharmacol. 643 ( 2-3 ) 267 - 273 2010.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1016/j.ejphar.2010.06.037.
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-j.ejphar.2010.06.037
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In vivo glycyrrhizin accelerates liver regeneration and rapidly lowers serum transaminase activities in 70% partially hepatectomized rats Reviewed
Mitsutoshi Kimura, Tadashi Moro, Hajime Motegi, Hiroyuki Maruyama, Mariko Sekine, Hiroshi Okamoto, Hideo Inoue, Toshitsugu Sato, and Masahiko Ogihara
Eur. J.Pharmacol. 579 ( 1-3 ) 357 - 364 2008.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Prostaglandin E(2) (EP(1)) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-alpha. Reviewed
Kimura M, Osumi S, and Ogihara M.
Endocrinology 142 ( 10 ) 4428 - 4440 2001.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists. Reviewed
Mitsutoshi Kimura and Masahiko Ogihara
J. Pharmacol. Exp. Ther. 291 ( 1 ) 171 - 180 1999.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Expression of alpha2- and beta2-adrenergic responses by hepatocyte growth factor and platelet-derived growth factor in primary cultures of adult rat hepatocytes. Reviewed
Kimura M, and Ogihara M.
Biol Pharm Bull. 21 ( 1 ) 22 - 28 1998.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents. Reviewed
Kimura M, Ogihara M.
Eur J Pharmacol. 324 ( 2-3 ) 267 - 276 1997.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Preparation, solubility, and anti-inflammatory effects of a complex of diphenylcyclopropenone/β-cyclodextrin derivatives as the treatment of alopecia areata. Reviewed
Y. Inoue, K. Yoshino, S. Kudo, N. Kodama, H. Moteki, M. Kimura,
J. Pharm. Pharm. Sci. 27 13230 2024
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S‑Allylcysteine and Cyclodextrins
Rino Tachikawa, Hiroki Saito, Hajime Moteki, Mitsutoshi Kimura, Hiroaki Kitagishi, Florencio Arce, Jr., Gerard Lee See, Takashi Tanikawa, and Yutaka Inoue
ACS Omega 7 ( 35 ) 31233 - 31245 2022.08
Language：English Publishing type：Research paper (scientific journal)
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Role of IGF-I in the intracellular signaling pathway of growth hormone-stimulated hepatocyte proliferation. Invited Reviewed
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, and Masahiko Ogihara
Current Topics in Pharmacology 25 9 - 14 2021.06
Language：English Publishing type：Research paper (scientific journal)
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Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions Reviewed
Ezawa T, Inagaki Y, Kashiwaba K, Matsumoto N, Moteki H, Murata I, Inoue Y, Kimura M, Ogihara M, and Kanamoto I.
ACS Omega 6 ( 10 ) 6953 - 6964 2021.03
Language：English Publishing type：Research paper (scientific journal)
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Delivery of acetaminophen to the central nervous system and the pharmacological effect after intranasal administration with a mucoadhesive agent and absorption enhancer Reviewed
Kaho Ogawa, Masaki Uchida, Tsutomu Yamaki, Hirokazu Matsuzaki, Mitsutoshi Kimura, Mari Okazaki, Hiroyuki Uchida, Hideshi Natsume
Int. J. Pharm. 594 120046 2021.02
Language：English Publishing type：Research paper (scientific journal)
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Autocrine secretion of insulin-like growth factor-I mediates growth hormone-stimulated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes Reviewed
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, and Masahiko Ogihara
Eur. J. Pharmacol. 891 173753 2021.01
Language：English Publishing type：Research paper (scientific journal)
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Growth Hormone Signaling Pathway Leading to the Induction of DNA Synthesis and Proliferation in Primary Cultured Hepatocytes of Adult Rats Reviewed
Kazuki Kurihara, Hajime Moteki, Masahiko Ogihara, and Mitsutoshi Kimura
J. Pharm. Pharm. Sci. 24 1 - 15 2021.01
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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The Enhancing Effects of S-Allylcysteine on Liver Regeneration Are Associated with Increased Expression of mRNAs Encoding IGF-1 and Its Receptor in Two-Thirds Partially Hepatectomized Rats Reviewed
Kazuki Kurihara, Hajime Moteki, Hideshi Natsume, Masahiko Ogihara, and Mitsutoshi Kimura
Biol. Pharm. Bull. 43 ( 11 ) 1776 - 1784 2020.11
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Relationship between the Use of Dihydropyridine Calcium Channel Blockers and the Risk of Reflux Esophagitis Reviewed
Hajime Moteki, Syotaro Nakamura, Masahiko Ogihara, Koichi Saito, and Mitsutoshi Kimura
J Community Pharm Pharm Sci 11 142 - 150 2019.08
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)
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Role of serotonin in liver regeneraton Invited Reviewed
Kota Naito, Hajime Moteki, Mitsutoshi Kimura, and Masahiko Ogihara
Current Topics in Pharmacology 23 39 - 44 2019.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Effect of selective serotonin (5-HT)2B receptor agonist BW723C86 on epidermal growth factor/transforming growth factor-α receptor tyrosine kinase and ribosomal p70 S6 kinase activities in primary cultures of adult rat hepatocytes Reviewed
Kota Naito, Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, Hideshi Natsume, Msahiko Ogihara
Biol. Pharm. Bull. 2019.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Enhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats
42 ( 1 ) 144 - 148 2019.01
Language：English Publishing type：Research paper (scientific journal) Publisher：Biological and Pharmaceutical Bulletin
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Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine. Reviewed
Kamiya Y, Yamaki T, Omori S, Uchida M, Ohtake K, Kimura M, Yamazaki H, Natsume H.
Pharmaceuticals (Basel). 2018.01
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3390/ph11010009.
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リウマトレックスによる間質性肺炎を例にした重篤な副作用の情報提供に対する非関節リウマチ患者の意識調査 Reviewed
茂木 肇、遠藤 栞、木村 光利、小松 由美子、荻原 政彦
薬局薬学 9 150 - 158 2017.06
Language：Japanese Publishing type：Research paper (scientific journal)
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Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer. Reviewed
Kamiya Y, Yamaki T, Uchida M, Hatanaka T, Kimura M, Ogihara M, Morimoto Y, Natsume H
Biol. Pharm. Bull. 40 ( 2 ) 205 - 211 2017
Language：English Publishing type：Research paper (scientific journal)
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Effects of oxethazaine and gamma-cyclodextrin complex formation on intestinal contractions. Reviewed
Yutaka Inoue, Rina Suzuki, Misa Horage, Mio Togano, Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara, Shigeru Ando, Junko Kikuchi, Isamu Murata, Ikuo Kanamoto
World J. Pharm. Sci. 4 ( 9 ) 269 - 280 2016.08
Language：English Publishing type：Research paper (scientific journal)
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カルシウム拮抗薬とグレープフルーツジュースの相互作用に関するパンフレット配布による教育効果の検討 Reviewed
茂木 肇、中村 梨絵、木村 光利、白石 卓也、荻原 政彦
薬局薬学 ( 8 ) 114 - 120 2016.08
Language：Japanese Publishing type：Research paper (scientific journal)
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Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes. Invited
Kota Naito, Hajime Moteki, Mitsutoshi Kimura, Hideshi Natsume, Masahiko Ogihara
Biol. Pharm. Bull. 39 ( 4 ) 570 - 577 2016.01
Language：English Publishing type：Research paper (scientific journal)
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Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Reviewed
Kota Naito, Chizuru Tanaka, Manami Mitsuhashi, Hajime Moteki, Mitsutoshi Kimura, Hideshi Natsume, and Masahiko Ogihara
Biol. Pharm. Bull. 39 ( 1 ) 121 - 129 2016
Language：English Publishing type：Research paper (scientific journal)
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L-ascorbic acid- and L-ascorbic acid 2-glucoside accelerate in vivo liver regeneration and lower serum alanine aminotransaminase activity in 70% partially hepatectomized rats. Reviewed
Mitsutoshi Kimura, Hajime Moteki, Masaki Uchida, Hideshi Natsume, Masahiko Ogihara
Biol. Pharm. Bull. 37 ( 4 ) 597 - 603 2014.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effect of poly-L-arginine on intestinal absorption of hydrophilic macromolecules in rats. Reviewed
Yamaki T, Uchida M, Kuwahara Y, Shimazaki Y, Ohtake K, Kimura M, Uchida H, Kobayashi J, Ogihara M, Morimoto Y, Natsume H.
Biol Pharm Bull. 36 ( 3 ) 496 - 500 2013.03
Language：English Publishing type：Research paper (scientific journal)
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Signal transduction mechanism for potentiation by α1- and β2-adrenoceptor agonists of L-ascorbic acid-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Reviewed
Hajime Moteki, Mitsutoshi Kimura, Katsuyoshi Sunaga, Tadashi Tsuda, and Masahiko Ogihara
Eur. J. Pharmacol. 700 ( 1-3 ) 2 - 12 2013.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Signal transduction pathway for L-ascorbic acid- and L-ascorbic acid 2-glucoside-induced DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes Reviewed
Hajime Moteki, Yuya Shimamura, Mitsutoshi Kimura, and Masahiko Ogihara
Eur. J. Pharmacol. 683 ( 1-3 ) 276 - 284 2012.03
Language：English Publishing type：Research paper (scientific journal)
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Activation of extracellular-signal regulated kinase by epidermal growth factor is potentiated by cAMP-elevating agents in primary cultures of adult rat hepatocytes. Reviewed
Hajime Moteki, Mitsutoshi Kimura, and Masahiko Ogihara
Biol. Pharm. Bull. 34 ( 10 ) 1542 - 1552 2011.10
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1248/bpb.34.1542
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Activation of extracellular-signal regulated kinase by platelet-derived growth factor is potentiated by phenylephrine in primary cultures of adult rat hepatocytes. Reviewed
Moteki H, Kimura M, Ogihara M
Biol Pharm Bull 34 ( 7 ) 980 - 986 2011.07
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
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Inhibitory effects of dexamethasone on epidermal growth factor-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Reviewed
Kimura M, Moteki H, Ogihara M
Biol Pharm Bull 34 ( 5 ) 682 - 687 2011.05
Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
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IP receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-alpha. Reviewed
Kimura M,Okamoto H, Natsume H, Ogihara M.
J. Pharmacol. Sci. 109 ( 4 ) 618 - 629 2009.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-13473506-109_618
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Tumor necrosis factor (TNF) receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-alpha Reviewed
Hiroshi Okamoto, Mitsutoshi Kimura, Noriyuki Watanabe, and Masahiko Ogihara
Eur. J. Pharmacol. 604 ( 1-3 ) 12 - 19 2009.02
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes Reviewed
Kimura M, Okamoto H, Ogihara M.
J. Pharmacol. Sci. 103 ( 4 ) 398 - 407 2007.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Stimulatory effects of glycyrrhizin on proliferation of rat hepatocytes in primary culture and on liver regeneration in partially hepatectomized rats. Invited
Kimura M
Minophagen Medical Review 35 81 - 86 2006.12
Authorship：Lead author Language：English Publishing type：Research paper (international conference proceedings)
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Effect of N-acetylcysteine after oral administration on nephropathy induced by an iodinated contrast medium Reviewed
Hiroshi Okamotol, Masahiro Miyauchi, Masami Nishiyama, Takayuki Miyake, Masami Sakurada, Kazuo Ohtake, Jun Kobayashi, Masahiko Ogihara, Mitsutoshi Kimura, Hideshi Natsume
39 ( 9 ) 915 - 923 2006.09
Language：Japanese Publishing type：Research paper (scientific journal)
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Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes Reviewed
Mitsutoshi Kimura, and Masahiko Ogihara
Eur. J.Pharmacol. 510 ( 3 ) 167 - 180 2005.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors. Reviewed
Kimura M, Inoue H, Hirabayashi K, Natsume H, Ogihara M.
Eur. J. Pharmacol. 431 ( 2 ) 151 - 161 2001.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Stimulation of DNA synthesis and proliferation by prostaglandins in primary cultures of adult rat hepatocytes. Reviewed
Kimura M, Osumi S, Ogihara M.
Eur. J. Pharmacol. 404 ( 3 ) 259 - 271 2000.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Transforming growth factor-beta1 inhibits the growth of primary adult rat hepatocyte cultures by increasing cAMP levels. Reviewed
Kimura M, and Ogihara M.
Eur. J. Pharmacol. 386 ( 2-3 ) 271 - 277 1999.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Proliferation of adult rat hepatocytes in primary culture induced by several growth factors is controlled by adrenergic responses Reviewed
Mitsutoshi Kimura
1998.09
Authorship：Lead author Language：Japanese Publishing type：Thesis (other)
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Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Reviewed
Mitsutoshi Kimura, and Masahiko Ogihara
Eur. J. Pharmacol. 354 ( 2-3 ) 271 - 281 1998.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Inhibitory effects of shimotsu-to, a traditional Chinese herbal prescription, on ultraviolet radiation-induced cell damage and prostaglandin E2 release in cultured Swiss 3T3 cells Reviewed
Sakuma K, Ogawa M, Kimura M, Yamamoto K, Ogihara M.
Yakugaku Zasshi 118 ( 6 ) 241 - 247 1998.06
Language：English Publishing type：Research paper (scientific journal)
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Proliferation of adult rat hepatocytes in primary cultures induced by platelet-derived growth factor is potentiated by phenylephrine. Reviewed
Kimura M, Ogihara M.
Jpn. J. Pharmacol. 76 ( 2 ) 165 - 174 1998.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1254/jjp.76.165.
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-13473506-76_165
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Proliferation of adult rat hepatocytes by hepatocyte growth factor is potentiated by both phenylephrine and metaproterenol. Reviewed
Kimura M, and Ogihara M.
282 ( 3 ) 1146 - 1154 1997.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Proliferation of adult rat hepatocytes in primary culture induced by insulin is potentiated by cAMP-elevating agents. Reviewed
Mitsutoshi Kimura, and Masahiko Ogihara
Eur J Pharmacol. 327 ( 1 ) 87 - 95 1997.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebrocortical neurons in culture. Reviewed
Ishitani R, Kimura M, Sunaga K, Katsube N, Tanaka M, Chuang DM.
J Pharmacol Exp Ther. 278 ( 1 ) 447 - 454 1996.07
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Tryptamine induces phosphoinositide turnover and modulates adrenergic and muscarinic cholinergic receptor function in cultured cerebellar granule cells. Reviewed
Ishitani R, Kimura M, Takeichi M, Chuang DM.
J Neurochem. 63 ( 6 ) 2080 - 2085 1994.12
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)