Papers - KIMURA Mitsutoshi
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Role of Hepatocyte Growth Regulators in Liver Regeneration Invited Reviewed
Mitsutoshi Kimura, Hajime Moteki and Masahiko Ogihara
Cells 12 ( 2 ) 208 - 220 2023.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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健康サポート薬局における健康相談会の相談・体験コーナー参加者に対する興味・関心度に関する調査 Reviewed
茂木 肇，山本雅人，臼井達洋，木村光利
日本地域薬局薬学会誌 12 122 - 132 2024.12
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)
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Phenylephrine enhances the mitogenic effect of S-allyl-L-cysteine on primary cultured hepatocytes through protein kinase C-induced B-Raf phosphorylation. Reviewed
H. Moteki, M. Ogihara, M. Kimura,
Biol. Pharm. Bull. 47 1565 - 1574 2024
Authorship：Last author Language：English
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Cell proliferation effects of S-allyl-L-cysteine are associated with phosphorylation of janus kinase 2, insulin-like growth factor type-I receptor tyrosine kinase, and extracellular signal-regulated kinase 2 in primary cultures of adult rat hepatocytes Reviewed
Hajime Moteki, Masahiko Ogihara, Mitsutoshi Kimura
Eur J Pharmacol. 927 175067 2022.07
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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S-Allyl-L-cysteine Promotes Cell Proliferation by Stimulating Growth Hormone Receptor/Janus Kinase 2/Phospholipase C Pathways and Promoting Insulin-Like Growth Factor Type-I Secretion in Primary Cultures of Adult Rat Hepatocytes Reviewed
Hajime Moteki, Masahiko Ogihara, and Mitsutoshi Kimura
Biol. Pharm. Bull. 45 ( 5 ) 625 - 634 2022.05
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation. Reviewed
Mitsutoshi Kimura, Hajime Moteki, and Masahiko Ogihara
Eur J Pharmacol. 745 223 - 233 2014.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Inhibitory effects of dexamethasone on hepatocyte growth factor-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Reviewed
Mitsutoshi Kimura, Hajime Moteki, and Masahiko Ogihara
J Pharmacol. Sci. 115 ( 3 ) 390 - 398 2011.03
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70% partially hepatectomized rats, in vivo. Reviewed
Mitsutoshi Kimura, Makiko Watanabe, Naoto Ishibashi, Shingo Yanagida, and Masahiko Ogihara
Eur J Pharmacol. 643 ( 2-3 ) 267 - 273 2010.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1016/j.ejphar.2010.06.037.
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-j.ejphar.2010.06.037
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In vivo glycyrrhizin accelerates liver regeneration and rapidly lowers serum transaminase activities in 70% partially hepatectomized rats Reviewed
Mitsutoshi Kimura, Tadashi Moro, Hajime Motegi, Hiroyuki Maruyama, Mariko Sekine, Hiroshi Okamoto, Hideo Inoue, Toshitsugu Sato, and Masahiko Ogihara
Eur. J.Pharmacol. 579 ( 1-3 ) 357 - 364 2008.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Prostaglandin E(2) (EP(1)) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-alpha. Reviewed
Kimura M, Osumi S, and Ogihara M.
Endocrinology 142 ( 10 ) 4428 - 4440 2001.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists. Reviewed
Mitsutoshi Kimura and Masahiko Ogihara
J. Pharmacol. Exp. Ther. 291 ( 1 ) 171 - 180 1999.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Expression of alpha2- and beta2-adrenergic responses by hepatocyte growth factor and platelet-derived growth factor in primary cultures of adult rat hepatocytes. Reviewed
Kimura M, and Ogihara M.
Biol Pharm Bull. 21 ( 1 ) 22 - 28 1998.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents. Reviewed
Kimura M, Ogihara M.
Eur J Pharmacol. 324 ( 2-3 ) 267 - 276 1997.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Preparation, solubility, and anti-inflammatory effects of a complex of diphenylcyclopropenone/β-cyclodextrin derivatives as the treatment of alopecia areata. Reviewed
Y. Inoue, K. Yoshino, S. Kudo, N. Kodama, H. Moteki, M. Kimura,
J. Pharm. Pharm. Sci. 27 13230 2024
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S‑Allylcysteine and Cyclodextrins
Rino Tachikawa, Hiroki Saito, Hajime Moteki, Mitsutoshi Kimura, Hiroaki Kitagishi, Florencio Arce, Jr., Gerard Lee See, Takashi Tanikawa, and Yutaka Inoue
ACS Omega 7 ( 35 ) 31233 - 31245 2022.08
Language：English Publishing type：Research paper (scientific journal)
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Role of IGF-I in the intracellular signaling pathway of growth hormone-stimulated hepatocyte proliferation. Invited Reviewed
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, and Masahiko Ogihara
Current Topics in Pharmacology 25 9 - 14 2021.06
Language：English Publishing type：Research paper (scientific journal)
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Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions Reviewed
Ezawa T, Inagaki Y, Kashiwaba K, Matsumoto N, Moteki H, Murata I, Inoue Y, Kimura M, Ogihara M, and Kanamoto I.
ACS Omega 6 ( 10 ) 6953 - 6964 2021.03
Language：English Publishing type：Research paper (scientific journal)
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Delivery of acetaminophen to the central nervous system and the pharmacological effect after intranasal administration with a mucoadhesive agent and absorption enhancer Reviewed
Kaho Ogawa, Masaki Uchida, Tsutomu Yamaki, Hirokazu Matsuzaki, Mitsutoshi Kimura, Mari Okazaki, Hiroyuki Uchida, Hideshi Natsume
Int. J. Pharm. 594 120046 2021.02
Language：English Publishing type：Research paper (scientific journal)
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Autocrine secretion of insulin-like growth factor-I mediates growth hormone-stimulated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes Reviewed
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, and Masahiko Ogihara
Eur. J. Pharmacol. 891 173753 2021.01
Language：English Publishing type：Research paper (scientific journal)
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Growth Hormone Signaling Pathway Leading to the Induction of DNA Synthesis and Proliferation in Primary Cultured Hepatocytes of Adult Rats Reviewed
Kazuki Kurihara, Hajime Moteki, Masahiko Ogihara, and Mitsutoshi Kimura
J. Pharm. Pharm. Sci. 24 1 - 15 2021.01
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)