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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Title |
Associate Professor |
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Laboratory Address |
埼玉県坂戸市けやき台1-1 21号館907号室 |
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Laboratory Phone number |
+81-49-271-7546 |
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Laboratory Fax number |
+81-49-271-7546 |
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Contact information |
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External Link |
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OHTAKE Kazuo
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Research Areas 【 display / non-display 】
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Life Science / Food sciences / 生活習慣病 がん 心不全 高血圧 糖尿病 脂質異常症 肥満
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Life Science / Physiology / 細胞生理学 人体の構造と機能 電気生理学
From School 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Science Graduated
- 1996.03
Country：Japan
From Graduate School 【 display / non-display 】
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Associate Professor
2017.04
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Assistant Professor
2015.04 - 2017.03
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Josai University Faculty of Pharmaceutical Sciences Department of Clinical Dietetics and Human Nutrition Assistant Professor
2007.04 - 2015.03
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Josai University Faculty of Pharmaceutical Sciences Department of Clinical Dietetics and Human Nutrition Research Assistant
2001.04 - 2007.03
Professional Memberships 【 display / non-display 】
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日本薬理学会
2015.04
Papers 【 display / non-display 】
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L-NAME誘発性高血圧ラットの内皮機能不全と心臓リモデリングに対する魚油摂取の効果 Reviewed
薗田邦博, 河野有華, 大竹一男, 竹之内康広, 柴祥子, 小林順, 加園恵三
金城学院大学消費生活科学研究所紀要 28 ( 1 ) 13 - 28 2024.03
Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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異なるジューサーを用いて作製した野菜果物ジュースの硝酸塩含有量と官能検査の比較 Reviewed
薗田 邦博、河野 有華、清水 彩子、大竹 一男、柴 祥子、加園 恵三、小林 順
金城学院大学消費生活科学研究所紀要 27 ( 1 ) 11 - 20 2023.03
Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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非アルコール性脂肪肝炎モデル動物の肝炎と肝線維化に対するSodium nitriteとCaptoprilの併用投与による影響 Reviewed
河野 有華、 薗田 邦博、大竹 一男、 柴 祥子、北森 一哉、小林 順
金城学院大学消費生活科学研究所紀要 27 ( 1 ) 1 - 10 2023.03
Language：Japanese
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Nitric oxide bioavailability for red blood cell deformability in the microcirculation: A review of recent progress. Reviewed International journal
Jun Kobayashi, Kazuo Ohtake, Isamu Murata, Kunihiro Sonoda
Nitric oxide : biology and chemistry 129 25 - 29 2022.12
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
The rheological properties of red blood cells (RBCs) play an important role in their microcirculation. RBCs can elastically deform in response to mechanical forces to pass through narrow vessels for effective gas exchange in peripheral tissues. Decreased RBC deformability is observed in lifestyle-related diseases such as diabetes mellitus, hypercholesterolemia, and hypertension, which are pathological conditions linked to increased oxidative stress and decreased nitric oxide (NO) bioavailability. Redox-sensitive cysteine residues on RBC cytoskeletal proteins, such as α- and β-spectrins, responsible for membrane flexibility, are affected by prolonged oxidative stress, leading to reversible and irreversible oxidative modifications and decreased RBC deformability. However, endogenously, and exogenously generated NO protects RBC membrane flexibility from further oxidative modification by shielding redox-sensitive cysteine residues with a glutathione cap. Recent studies have shown that nitrate-rich diets and moderate exercise can enhance NO production to increase RBC deformability by increasing the interplay between RBCs and vascular endothelium-mediated NO bioavailability for microcirculation. This review focuses on the molecular mechanism of RBC- and non-RBC-mediated NO generation, and how diet- and exercise-derived NO exert prophylactic effects against decreased RBC deformability in lifestyle-related diseases with vascular endothelial dysfunction.
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Effects of dietary palmitoleic acid on vascular function in aorta of diabetic mice. Reviewed International journal
Yasuhiro Takenouchi, Yoshie Seki, Sachiko Shiba, Kazuo Ohtake, Koji Nobe, Keizo Kasono
BMC endocrine disorders 22 ( 1 ) 103 - 103 2022.04
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Chronic hyperglycemia in diabetes causes atherosclerosis and progresses to diabetic macroangiopathy, and can lead to coronary heart disease, myocardial infarction and cerebrovascular disease. Palmitoleic acid (POA) is a product of endogenous lipogenesis and is present in fish and vegetable oil. In human and animal studies, POA is reported as a beneficial fatty acid related to insulin sensitivity and glucose tolerance. However, few studies have reported its effects on aortic function in diabetes. Here, we investigated the effects of POA administration on vascular function in KKAy mice, a model of type 2 diabetes. METHODS: Male C57BL/6 J (control) and KKAy (experimental) mice at the age of 14 weeks were used in the present study. For each mouse strain, one group was fed with reference diet and a second group was fed POA-containing diet for 2 weeks. The vascular reactivities of prepared aortic rings were then measured in an organ bath to determine if POA administration changed vascular function in these mice. RESULTS: KKAy mice treated with POA exhibited decreased plasma glucose levels compared with mice treated with reference diet. However, endothelium-dependent vasorelaxant responses to acetylcholine and protease-activated receptor 2 activating protein, which are attenuated in the aorta of KKAy mice compared to C57BL/6 J mice under a reference diet, were not affected by a 2-week POA treatment. In addition, assessment of vasoconstriction revealed that the phenylephrine-induced vasoconstrictive response was enhanced in KKAy mice compared to C57BL/6 J mice under a reference diet, but no effect was observed in KKAy mice fed a POA-containing diet. In contrast, there was an increase in vasoconstriction in C57BL/6 J mice fed the POA-containing diet compared to mice fed a reference diet. Furthermore, the vasoconstriction in aorta in both C57BL/6 J and KKAy mice fed a POA-containing diet were further enhanced under hyperglycemic conditions compared to normal glucose conditions in vitro. In the hyperinsulinemic, and hyperinsulinemic combined with hyperglycemic conditions, vasoconstriction was increased in KKAy mice fed with POA. CONCLUSION: These results suggest that POA intake enhances vasoconstriction under hyperglycemic and hyperinsulinemic conditions, which are characteristics of type 2 diabetes, and may contribute to increased vascular complications in diabetes.
Books and Other Publications 【 display / non-display 】
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注射剤・経口製剤に代わる 新しい薬剤投与デバイスの開発
大竹一男他（ Role： Joint author , 株式会社技術情報協会 2014;7(6):154-160）
株式会社技術情報協会 2014
Responsible for pages：154-160 Language：Japanese Book type：Scholarly book
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～医療ニーズ、規制、最新技術、薬価、事業戦略、事例をふまえた～ＤＤＳ製剤の開発・評価と実用化手法
大竹一男他（ Role： Joint author）
技術情報協会 2013.04
Language：Japanese Book type：Scholarly book
2013;1(1):21-28
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難吸収性薬物の吸収性改善と新規投与製剤の開発
大竹一男他（ Role： Joint author）
シーエムシー出版 2012.04
Language：Japanese Book type：Scholarly book
2012;5:192-200
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食品－医薬品相互作用ハンドブック(新版)
大竹一男他、城西大学薬学部医療栄養学科(共訳)（ Role： Joint author）
丸善株式会社 2011.04
Language：Japanese Book type：Scholarly book
2011;14:294-303, 22:433-464.
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医薬品製剤における＜最新＞剤形・処方設計ノウハウ集
大竹一男（ Role： Joint author）
株式会社 技術情報協会 2005.12
Language：Japanese Book type：Scholarly book
2005;4(4):354-383.
Misc 【 display / non-display 】
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硝酸塩由来NO補給を期待した国内野菜果物ジュースや粉末中の硝酸塩と抗酸化能の比較
大竹一男, 河野有華, 薗田邦博, 清水彩子, 飯野汐里, 齋籐百花, 柴 祥子, 加園恵三, 小林 順
第77回日本酸化ストレス学会・第23回日本NO学会合同学術集会 要旨集 2024.05
Authorship：Lead author, Corresponding author
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Effects of antihypertensive drugs on survival rate and cardiac remodeling in heart failure rats with preserved left ventricular ejection fraction
河野有華, 薗田邦博, 大竹一男, 柴祥子, 北森一哉, 渡辺彰吾
日本薬学会年会要旨集(Web) 144th 2024
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亜硝酸塩とカプトプリルの併用によるNASHモデル動物の肝線維化抑制効果
河野 有華, 薗田 邦博, 北森 一哉, 大竹 一男, 小林 順
日本薬学会年会要旨集 141年会 28P01 - 158S 2021.03
Language：Japanese Publisher：(公社)日本薬学会
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非アルコール性脂肪性肝疾患モデルラットの心肥大と線維化に対する亜硝酸塩の影響
薗田 邦博, 大竹 一男, 高村 亜矢乃, 河野 有華, 北森 一哉, 内田 博之, 伊東 順太, 加園 恵三, 小林 順
日本薬学会年会要旨集 139年会 ( 3 ) 120 - 120 2019.03
Language：Japanese Publisher：(公社)日本薬学会
Presentations 【 display / non-display 】
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Analysis of proliferative suppression of cancer stem-like cells in the three-dimensional prostate cancer cell line models
2024.11
Event date： 2024.11
Language：Japanese Presentation type：Poster presentation
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硝酸塩由来NO補給を期待した国内野菜果物ジュースや粉末中の硝酸塩と抗酸化能の比較
大竹一男、河野有華、薗田邦博、清水彩子、飯野汐里、齋籐百花、柴 祥子、加園恵三、小林 順
第77回日本酸化ストレス学会・第23回日本NO学会合同学術集会 2024.05
Event date： 2024.05
Language：Japanese Presentation type：Poster presentation
Venue：横須賀
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左室駆出率が保たれた心不全ラットの生存率と心臓リモデリングに与える降圧剤の影響
河野 有華、薗田 邦博、大竹 一男、柴 祥子、北森 一哉、渡辺 彰吾
日本薬学会第144年会（横浜） 2024.03
Event date： 2024.03
Language：Japanese Presentation type：Poster presentation
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三次元前立腺がん細胞株における魚油成分（EPA）によるがん幹細胞の増殖抑制作 用の解析
柴 祥子、大竹一男、加園 恵三
第５回がん三次元培養研究会（東京） 2024.02 がん三次元培養研究会
Event date： 2024.02
Language：Japanese Presentation type：Poster presentation
Venue：東京
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NAFLDモデルラットの肝炎に対する亜硝酸塩の予防効果
河野 有華、薗田 邦博、北森 一哉、大竹 一男、小林 順
第57回 高血圧関連疾患モデル学会学術総会（CVMWとの合同開催） （福岡） 2021.12
Event date： 2021.12
Awards 【 display / non-display 】
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Young Podium Presenter Award
2006.07 Second International Meeting on the Role of Nitrite in Physiology, Pathophysiology, and Therapeutics; Natcher Conference Center, National Institutes of Health; Bethesda, Maryland. Hypotensive effect of nitrite on experimental rat hypertension is mediated through multiple oxidoreductase-involved pathways.
Kazuo Ohtake
Scientific Research Funds Acquisition Results 【 display / non-display 】
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The effect of prophylactic supplementation of insufficient micronutrients for cognitive impairment in Japanese senile.
Grant number：17K01866 2017.04 - 2021.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Kasono Keizo
Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）
Preventive effects on cognitive decline in elderly peoples can be expected by supplementation of micronutrients.
１．ADAS-Jcog is useful tool for early detection of cognitive decline in elderly peoples：Correlationship between age and ths score of ADAS-Jcog is higher than those of HDS-R or MMSE. Then ADAS-Jcog is useful tool for early detection of cognitive decline in elderly peoples.２．Preventive effects on cognitive decline in elderly peoples can be expected by supplementation of micronutrients：The cognitive decline defined by HDS-R or ADAS-Jcog was inhibited significantly in the male Tezon group compared with the male control group. However, the cognitive decline was not inhibited in the female Tezon group compared with the female control group. -
The investigations of the effects of fatty acids consumption or direct administration on the functions of cardiovascular system.
Grant number：26350904 2014.04 - 2017.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Keizo Kasono
Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）
<1> The administration of palmitoleic acid (POA) for 2 weeks improved the insulin resistance and reduced the plasma glucose levels in diabetic model mice (KKA-y). It was speculated that the administration of POA compensatory increased the relaxation response induced by PPAR-δ.<2> Eicosapentaenoic acid (EPA) dose-dependently decreased the up-regulated protein levels of VCAM-1 and ICAM-1 induced by TNF-α in human aortic endothelial cells.<3> It is speculated that fish oil supplementation reduces the cardiovascular loading induced by increase of Ht during hypoxic training without blunting the improvement of endurance performance.
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tudy of therapeutic effect of sodium nitrite on crush syndrome
Grant number：22592021 2010 - 2012
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
KOBAYASHI Jun, OHTAKE Kazuo, MURATA Isamu
Grant amount：\3640000 （ Direct Cost: \2800000 、 Indirect Cost：\840000 ）
We developed crush syndrome (CS) rat model to evaluate the therapeutic effect of nitrite on crush syndrome. Intraperitoneal single injection of nitrite improved survival rate of this CS model from 25% to 64%, furthermore combined therapy of continuous infusion of nitrite with conventional therapies including massive fluid infusion and correction of acidosis resulted in 100% survival rate. This might be due to the tissue protective effect of nitrite-derived nitric oxide (NO) against ischemia/reperfusion injury. A 100% survival rate was also achieved by the treatment of the CS rat with single injection of dexamethasone through a mechanism involving NO production in the injured skeletal muscle．These results provide not only a new protective mechanism against ischemia/reperfusion injury in this syndrome, but also a simple and promising drug therapy especially useful in the field of disasters
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The role of neuronal and inducible NOS in the regulation of intestinal apoptosis in fasting and refeeding rat
Grant number：22591492 2010 - 2012
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
UCHIDA Hiroyuki, OTAKE Kazuo
Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）
To investigate the change and role of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) on decreasing intestinal apoptosis of refeeding after fasting in rats and to define whether the recovery of the intestinal mucosa atrophy by refeeding is associated with the levels of nitric oxide synthases (NOSs) in the jejunum. These results suggest that nNOS-involved control might be present in the regulation of iNOS activity and its-mediated apoptosis in fasting and refeeding.
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Effect of nitorosylated- and phosphorylated-RKIP on cell-proliferation signal in gastric cancer cells
Grant number：20790505 2008 - 2009
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
OHTAKE Kazuo
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
The purpose of the current study is to evaluate the effect of nitorosylated- and phosphorylated-RKIP (Raf kinase inhibitor protein) on cell-proliferation signal in human gastric cancer (AGS) cells. RKIP-nitrosylation was significant reduction in the phophorylation level of RKIP in AGS cells. On the other hand, cell proliferation signal was up-regulated by an expressive increase in nitrosylation level of RKIP.
Other External Funds 【 display / non-display 】
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肥満を伴うインスリン抵抗性マウスに及ぼす亜硝酸塩摂取の影響に関する研究（計3回獲得）
2010.05 - 2012.04
厚生労働省 日本食品化学研究振興財団 助成金
Grant type：Competitive
Preferred joint research theme 【 display / non-display 】
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野菜や野菜ジュース内のNOx含量の測定
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亜硝酸塩の疾病治療効果に関する研究
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野菜や野菜ジュースと運動機能との関係
Teaching Experience 【 display / non-display 】
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IPE（他職種連携教育）の教員ファシリテーター
2018 Institution：Saitama Prefectural University
Level：Undergraduate (specialized)
Social Activities 【 display / non-display 】
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(3) ＜生活習慣病を意識した＞一酸化窒素 (NO) の医薬品・スイッチOTC・トクホ・健康食品・食品への目の付けどころ情報機構セミナー
2006.10
企業向け講演
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(2) 経鼻吸収型製剤の開発戦略と現状・今後の課題情報機構セミナー
2003.12
企業向け講演
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(1) 生体情報に基づく経鼻吸収型製剤の設計と最近の動向情報機構セミナー
2003.04
企業向け講演