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Affiliation |
Faculty of Pharmaceutical Sciences Department of Clinical Dietetics and Human Nutrition |
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Title |
Professor |
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Laboratory Address |
Keyaki-Dai 1-1 Sakado, Saitama, Japan |
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Laboratory Phone number |
049-271-7223 |
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Laboratory Fax number |
049-271-7223 |
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Contact information |
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External Link |
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KOBAYASHI Jun
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From School 【 display / non-display 】
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Hamamatsu University School of Medicine Faculty of Medicine Graduated
- 1981.03
Country：Japan
Studying abroad experiences 【 display / non-display 】
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1991.07 - 1994.03 The Hospital for Sick Children, Division of cardiovascular Reserch Fellow
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Professor
2002.04
Professional Memberships 【 display / non-display 】
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日本NO学会
2002.04
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日本薬学会
2002.04
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日本栄養食糧学会
2002.04
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日本循環器学会
1994.07
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日本小児科学会
1981.04
Papers 【 display / non-display 】
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Nitric oxide bioavailability for red blood cell deformability in the microcirculation: A review of recent progress. Reviewed
Jun Kobayashi, Kazuo Ohtake, Isamu Murata, Kunihiro Sonoda.
Nitric Oxide, 129 25 - 29 2022.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Shang Ran, Yuka Kono, Kunihiro Sonoda, Kazuya Kitamori, Kazuo Ohtake, Mari Mori, Theodore W Kurtz, Yukio Yamori, Jun Kobayashi, Hinako Nakayama, Taketo Fukuoka, Yuki Kawai, Haruka Tago, Nobuhisa Watanabe, Ikumi Sato, Shusei Yamamoto, Satoshi Hirohata, Shogo Watanabe
Prev Nutr Food Sci 30 ( 6 ) 539 - 548 2025.10
Language：English Publishing type：Research paper (scientific journal)
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薗田 邦博、河野 有華、大竹 一男、清水 彩子、柴 祥子、飯野 汐里、加園 恵三、小林 順
金城学院大学論集自然科学編 2024 2024.09
Authorship：Last author
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L-NAME誘発性高血圧ラットの内皮機能不全と心臓リモデリングに対する魚油摂取の効果
薗田 邦博、河野 有華、大竹 一男、竹之内 康広、柴 祥子、小林 順、加園 恵三
金城学院大学消費生活科学研究所紀要 2024.03
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Comparison of nitrate content and antioxidant capacity in beetroot juice made in Japan and UK Reviewed
Kinjo Gakuin Daigaku Ronshu：Studies in Natural Sciences 20 ( 1 ) 26 - 33 2023.09
Books and Other Publications 【 display / non-display 】
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Health Benefits of “Well Chewing” during Meals via Enterosalivary Nitrate–Nitrite–Nitric Oxide Pathway Reviewed International journal
Jun Kobayashi（ Role： Joint author , Perspective of Recent Advances in Medical Research Vol. 8）
BP International 2023.01 （ ISBN:978-81-19039-29-6 ）
Total pages：138 Responsible for pages：91-99 Language：English Book type：Scholarly book
DOI： 10.9734/bpi/pramr/v8
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Nitric Oxide Bioavailability and Insulin Resistance: An Overview Reviewed International journal
（ Role： Sole author）
2022.10 （ ISBN:978-93-5547-807-8 ）
Responsible for pages：79-95 Book type：Scholarly book
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Current Progress in Medicine and Medical Research Vol.7 Reviewed International journal
Jun Kobayashi , Isamu Murata（ Role： Joint author , Nitrite Infusion is a Successful Treatment for Rat Model of Crush Syndrome）
BP International 2023.08 （ ISBN: 978-81-19491-47-6 ）
Total pages：184 Responsible for pages：82-91 Language：English Book type：Scholarly book
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埼玉県薬剤師会雑誌 病態解析学研究室紹介（後編）
小林順、内田博之、伊東順太
埼玉県薬剤師会雑誌 2021.05
Responsible for pages：47 ( 5 ) 14 - 21
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病態解析学研究室紹介（前編）
小林順、内田博之、伊東順太
埼玉県薬剤師会雑誌 2021.04
Responsible for pages： 47 ( 4 ) 20 - 24
Presentations 【 display / non-display 】
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震災からの体調管理のアドバイス：特に循環器系疾患について Invited
小林 順
城西大学公開講座 2011.10 城西大学
Event date： 2011.10
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
Venue：埼玉県坂戸市けやき台１－１城西大学 Country：Japan
Other research activities 【 display / non-display 】
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Molecular Mechanisms and Treatment of Ischemia–Reperfusion Injury
2023 - 2024.09
Ischemia–reperfusion (I/R) injury is caused by a temporary restriction of blood supply to a particular organ, such as the heart, brain, kidney, liver and skeletal muscle. Subsequent reperfusion to these hypoxic or anoxic organs causes organ dysfunction and tissue cell death, sometimes leading to systemic circulatory shock. Although the organ type, as well as magnitude and duration of the interruption in the blood supply are critical determinants of whether the organ becomes necrotic or not, organ damage is essentially caused by oxidative stress following reperfusion, which induces cell membrane lipid peroxidation, mitochondrial dysfunction and subsequent inflammatory responses, such as neutrophil activation and the release of reactive oxygen species and other inflammatory mediators, including adhesion molecules and various cytokines. Effective pharmacological agents and methods to combat I/R injury have recently been developed. Nevertheless, we are far from establishing the treatment for this disease. I, therefore, look forward to fruitful discussions on this theme, particularly from the standpoint of molecular biology, and call for original articles and reviews focusing on the pathophysiology of I/R injury, development of animal models, and development of new pharmacological and interventional strategies. This Special Issue will provide a key resource to the readers of CIMB, including new findings related to I/R injury with the potential to lead to novel treatment strategies.
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Dietary Nitrate and Metabolic Health
2023 - 2024.08
Nitric oxide (NO) is endogenously generated from L-arginine and oxygen by NO synthases. In addition, inorganic nitrate from dietary sources generates NO and nitrosating agents, such as the S-nitroso compound, in the acidic stomach, thus providing local and systemic NO bioactivities. Recent evidence suggests that local and systemic NO bioavailability is associated with health maintenance through the nitrate–nitrite–NO pathway, and it is affected by many habitual and physiological factors, including dietary habits, oral commensal bacteria, gastric acidity, intestinal bacterial flora, and thiol-containing food and drugs. Therefore, it is important to discuss the association between diet, including dietary nitrate, and metabolic health from biological and physiological standpoints. Although dietary nitrate provides beneficial effects, it is a source of carcinogenic N-nitroso compounds under certain physiological conditions. Thus, this Special Issue also welcomes studies dealing with controversial findings. I look forward to fruitful discussions regarding dietary nitrate and metabolic health in this Special Issue. I welcome submissions of both original articles and reviews that will offer the readers of IJMS new findings and comprehensive explanations on dietary nitrate and metabolic health. These are necessary for the development of novel research approaches, particularly those related to health maintenance strategies.
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Topic editor "Recent Advances in the Management of Crush Syndrome: From Bench to Bedside"
2023 - 2024
Crush syndrome (CS) often occurs in victims of disasters such as earthquakes, traffic accidents, and warfare. CS is defined as a condition in which rhabdomyolysis develops after extrication from prolonged continuous pressure on limb skeletal muscles by heavy debris and the subsequent release of toxic substances into the bloodstream from re-perfused muscle tissues, leading to acute respiratory distress syndrome (ARDS), circulatory shock, metabolic acidosis, and acute renal failure (ARF). Despite the immediate start of treatment in the prehospital setting, such as intravenous fluid administration to correct hypovolemia, electrolyte abnormalities, and acidosis, prompt fasciotomies to suppress compartment syndrome, and prehospital tourniquet application to delay reperfusion injury, there is not yet a definitive on-site treatment; even amputation of injured extremities must be chosen for lifesaving when extrication is delayed. Developing CS treatment is urgently required when considering, for example, earthquake disasters that frequently occur around the world; however, due to the unfeasibility of human studies, animal models have been used both to clarify pathogenesis and pathophysiology of CS and to develop new therapeutic strategies. The research in this field has steadily progressed to pursuing new drug applications to skeletal muscle ischemia/reperfusion injury and the subsequent systemic inflammation, ARDS, and ARF.
Although the reports on therapeutic strategies published so far are based mainly on animal experiments, their applications to humans are of great interest. This Research Topic welcomes your manuscript dealing with recent progress in basic and clinical research on CS, including animal models, experimental protocols, and drug interventions with their therapeutic effects.
We look forward to fruitful discussions on this Research Topic and call for both original articles and reviews, which would provide the readers of Frontiers in Pharmacology with new findings and comprehensive elucidation about the etiology, mechanism, and symptoms of CS, which may lead to future therapeutic strategies in clinical practice. This issue will focus on but is not limited to, the following topics :
• Elucidation of the pathophysiology of crush syndrome
• Development of animal models for the study of crush syndrome
• Development of new pharmacological treatment strategies for crush syndrom -
Topic editor "Nitrite and Nitric Oxide in Life” for 6 MDPI journals
2022 - 2023
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Guset editor ”Nitric Oxide Biosynthesis Pathway and Nitric Oxide Signaling in Human Diseases”
2022 - 2023
Awards 【 display / non-display 】
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令和３年度栄養関係功労者厚生労働大臣表彰
2021.09 厚生労働省 栄養士養成功労者
小林順
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第34回日本小児循環器学会 肺高血圧症シンポジウム
1998.07 日本小児循環器学会
小林順
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第４４回日本心臓病学会学術集会 主演題 優秀賞
1996.09 日本心臓病学会
小林順
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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The Award of Medical Research Council of Canada Fellowship.
1991.07 カナダ政府
Other External Funds 【 display / non-display 】
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簡易型一酸化窒素発生装置を用いたラットクラッシュ症候群モデル救命治療に関する研究
2021.09 - 2023.08
城西大学 ２０２１年度学長所管研究
村田 勇、小林順、石原伸輔（国立研究開発法人物質・材料研究機構）
Grant type：Competitive
簡易型一酸化窒素(NO)発生装置を用いた災害現場でのクラッシュ症候群救命治療に関する研究。ラットモデルを使いNO吸入療法による治療効果並びに、他の注射用薬剤との併用による相加的、相乗的治療効果を検討すし、実用化に繋げる。
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胃液及び胃組織中のニトロソ化タンパク質の分析とその生理的機能変化に関する研究
2002.04 - 2003.03
平成14年度研究奨励金（共同研究）
小林順、内田博之、大竹一男
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肺動脈選択性一酸化窒素供与体による実験的肺高血圧症治療への応用
1999.04 - 2000.03
母子健康協会 母子健康協会第１１回医学助成研究
Grant type：Competitive
原発性肺高血圧症の治療は静注用プロスタグランデン製剤が中心となっているが、高価なこと副作用の点から、NO製剤の期待がある。しかし吸入用NOは、その毒性から医薬品として認められておらず、在宅などでの使用に制限がある。我々は静注用NOドナーとしてのGSNOの有効性を他のNOドナーと比較し、実験的肺高血圧症モデルを使って、証明した。さらに肺で選択的にガス状一酸化窒素を放出するメカニズムについても検討した。
Committee Memberships 【 display / non-display 】
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日本小児肺循環研究会 会長
2003.02
Committee type：Academic society
Media Coverage 【 display / non-display 】
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Is that a Blue Miracle? What do we know about Viagra and COVID-19? Did it really saved life? Internet
You Tube (https://www.youtube.com/watch?v=7-hKNd9x6uM) 2022.01
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The Unexpected Dangers of Mouthwash Internet
You Tube (https://www.youtube.com/watch?v=moKsVeL6sZs) 2022.05
Author：Other
Academic Activities 【 display / non-display 】
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科学研究費委員会専門委員
Role(s)： Review, evaluation
独立行政法人日本学術振興会 2012.12 - 2013.11
Type：academic_research
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Topic editor for ”Nitrite and Nitric Oxide in Life” International contribution
Role(s)： Supervision (editorial), Review, evaluation, Planning/Implementing academic research
Biology, Biomedicined, Current Issues in Molecular Biology, IJMS,J Mol Biol, life) 2022 - 2023
Type：peer_review_etc
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Guest editor for “Nitric Oxide Biosynthesis Pathway and Nitric Oxide Signaling in Human Diseases” International contribution
Role(s)： Review, evaluation, Planning/Implementing academic research, Peer review
International Journal of Molecular Sciences 2022 - 2023
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Guest editor of the special issue on "Nutrients and Nitrite" International contribution
Role(s)： Review, evaluation, Planning/Implementing academic research
Internationa Journal of molecular science 2020 - 2022
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Associate editor International contribution
Role(s)： Supervision (editorial), Review, evaluation
Immunoendocrinology 2015
Type：review