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Affiliation |
Faculty of Pharmaceutical Sciences Department of Clinical Dietetics and Human Nutrition |
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Title |
Professor |
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Laboratory Address |
Keyaki-Dai 1-1 Sakado, Saitama, Japan |
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Laboratory Phone number |
049-271-7223 |
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Laboratory Fax number |
049-271-7223 |
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Contact information |
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External Link |
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KOBAYASHI Jun
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From School 【 display / non-display 】
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Hamamatsu University School of Medicine Faculty of Medicine Graduated
- 1981.03
Country：Japan
Studying abroad experiences 【 display / non-display 】
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1991.07 - 1994.03 The Hospital for Sick Children, Division of cardiovascular Reserch Fellow
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Professor
2002.04
Professional Memberships 【 display / non-display 】
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日本栄養食糧学会
2002.04
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日本NO学会
2002.04
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日本薬学会
2002.04
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日本循環器学会
1994.07
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日本小児科学会
1981.04
Papers 【 display / non-display 】
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Nitric oxide bioavailability for red blood cell deformability in the microcirculation: A review of recent progress. Reviewed
Jun Kobayashi, Kazuo Ohtake, Isamu Murata, Kunihiro Sonoda.
Nitric Oxide, 129 25 - 29 2022.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Comparison of nitrate content and antioxidant capacity in beetroot juice made in Japan and UK Reviewed
Kinjo Gakuin Daigaku Ronshu：Studies in Natural Sciences 20 ( 1 ) 26 - 33 2023.09
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異なるジューサーを用いて作製した野菜果物ジュースの硝酸塩含有量と官能検査の比較 Reviewed
薗田邦博、河野有華、清水彩子、大竹一男、柴祥子、加園恵三、小林 順
金城学院大学消費生活科学研究所紀要 27 ( 1 ) 11 - 20 2023.03
Authorship：Last author Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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非アルコール性脂肪肝炎モデル動物の肝炎と肝線維化に対するSodium nitriteとCaptoprilの併用投与による影響 Reviewed
河野有華、 薗田邦博、大竹一男、柴祥子、北森一哉、小林順
金城学院大学消費生活科学研究所紀要 27 ( 1 ) 1 - 10 2023.03
Authorship：Last author Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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Salvianolic acid B improves the survival rate, acute kidney dysfunction, inflammation and NETosis‑mediated antibacterial action in a crush syndrome rat model Reviewed
Isamu Murata, Tsugumi Sugai,Yumiko Murakawa,Yoshiaki Miyamoto, Jun Kobayashi, Yutaka Inoue, Ikuo Kanamoto
Experimental and Therapeutic Medicine 23 ( 5 ) 2022.05
Language：English Publishing type：Research paper (scientific journal) Publisher：SPAMDIDOS PUBLICATIONS
Crush syndrome (CS) is a potentially lethal condition characterized by muscle cell damage resulting from decompression following compression. Patients with CS can develop cardiac failure, kidney dysfunction, shock, systemic inflammation and sepsis. Salvianolic acid B (SalB) has cardiac and kidney protective effects and anti‑oxidative, anti‑inflammatory, anti‑apoptotic and anti‑bacterial properties. The present study aimed to demonstrate the survival benefit of SalB in the CS rat model, which comprised anesthetized rats with bilateral hindlimb compression by a rubber tourniquet for 5 h. The rats examined were randomly divided into four groups: i) Sham; ii) sham treated with SalB; iii) CS rat model without treatment; and iv) CS rat model treated with SalB. Under continuous monitoring and recording of arterial blood pressures, blood and tissue samples were collected for biochemical analyses at designated timepoints before and after reperfusion. SalB administration improved the survival rate, kidney function (by treating shock and metabolic acidosis) and inflammation (by reducing mitochondrial dysfunction and endothelial damage). Reduced incidence of cardiac failure due to hyperkalemia was associated with reduced muscle injury via the prevention of mitochondrial dysfunction. Additionally, indirect antibacterial action by the neutrophil extracellular trap system (NETs) was observed. SalB administration to the CS rat model led to a substantial improvement in survival following CS by decreasing kidney and cardiac dysfunctions, inflammation, and endothelial dysfunction by improving the mitochondrial function and through antibacterial effects via NETs.
Books and Other Publications 【 display / non-display 】
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Health Benefits of “Well Chewing” during Meals via Enterosalivary Nitrate–Nitrite–Nitric Oxide Pathway Reviewed International journal
Jun Kobayashi（ Role： Joint author , Perspective of Recent Advances in Medical Research Vol. 8）
BP International 2023.01 （ ISBN:978-81-19039-29-6 ）
Total pages：138 Responsible for pages：91-99 Language：English Book type：Scholarly book
DOI： 10.9734/bpi/pramr/v8
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Nitric Oxide Bioavailability and Insulin Resistance: An Overview Reviewed International journal
（ Role： Sole author）
2022.10 （ ISBN:978-93-5547-807-8 ）
Responsible for pages：79-95 Book type：Scholarly book
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Current Progress in Medicine and Medical Research Vol.7 Reviewed International journal
Jun Kobayashi , Isamu Murata（ Role： Joint author , Nitrite Infusion is a Successful Treatment for Rat Model of Crush Syndrome）
BP International 2023.08 （ ISBN: 978-81-19491-47-6 ）
Total pages：184 Responsible for pages：82-91 Language：English Book type：Scholarly book
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An Overview on NO-Rich Diet for Lifestyle-Related Diseases
Jun Kobayashi、Kazuo Ohtake, Hiroyuki Uchida（ Role： Joint author）
B P International 2021.02
Responsible for pages：39-61 Language：English Book type：Scholarly book
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Nutrition Reviews 日本語版の『栄養学レビュー』最新刊 特集 硝酸塩摂取と健康：最新知見
小林順、大竹一男、薗田邦博（ Role： Joint author）
女子栄養大学出版部 2020.05
Language：Japanese Book type：Scholarly book
Other research activities 【 display / non-display 】
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Topic editor "Recent Advances in the Management of Crush Syndrome: From Bench to Bedside"
2023 - 2024
Crush syndrome (CS) often occurs in victims of disasters such as earthquakes, traffic accidents, and warfare. CS is defined as a condition in which rhabdomyolysis develops after extrication from prolonged continuous pressure on limb skeletal muscles by heavy debris and the subsequent release of toxic substances into the bloodstream from re-perfused muscle tissues, leading to acute respiratory distress syndrome (ARDS), circulatory shock, metabolic acidosis, and acute renal failure (ARF). Despite the immediate start of treatment in the prehospital setting, such as intravenous fluid administration to correct hypovolemia, electrolyte abnormalities, and acidosis, prompt fasciotomies to suppress compartment syndrome, and prehospital tourniquet application to delay reperfusion injury, there is not yet a definitive on-site treatment; even amputation of injured extremities must be chosen for lifesaving when extrication is delayed. Developing CS treatment is urgently required when considering, for example, earthquake disasters that frequently occur around the world; however, due to the unfeasibility of human studies, animal models have been used both to clarify pathogenesis and pathophysiology of CS and to develop new therapeutic strategies. The research in this field has steadily progressed to pursuing new drug applications to skeletal muscle ischemia/reperfusion injury and the subsequent systemic inflammation, ARDS, and ARF.
Although the reports on therapeutic strategies published so far are based mainly on animal experiments, their applications to humans are of great interest. This Research Topic welcomes your manuscript dealing with recent progress in basic and clinical research on CS, including animal models, experimental protocols, and drug interventions with their therapeutic effects.
We look forward to fruitful discussions on this Research Topic and call for both original articles and reviews, which would provide the readers of Frontiers in Pharmacology with new findings and comprehensive elucidation about the etiology, mechanism, and symptoms of CS, which may lead to future therapeutic strategies in clinical practice. This issue will focus on but is not limited to, the following topics :
• Elucidation of the pathophysiology of crush syndrome
• Development of animal models for the study of crush syndrome
• Development of new pharmacological treatment strategies for crush syndrom -
Guset editor ”Nitric Oxide Biosynthesis Pathway and Nitric Oxide Signaling in Human Diseases”
2022 - 2023
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Topic editor "Nitrite and Nitric Oxide in Life” for 6 MDPI journals
2022 - 2023
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Guest editor “Nutrient and Nitrite”
2020 - 2022
Although nitrate and nitrite were previously considered to be inert end products of endogenously produced nitric oxide (NO) in the process of NO oxygenation, they are now known to be physiologically recycled in the blood and tissue to form NO and other bioactive nitrogen oxides. Decreased NO availability, caused by obesity and endothelial dysfunction, might be causally related to the development of lifestyle-related diseases, such as insulin resistance, ischemic heart disease, and hypertension. However, dietary intake of nitrite as a nutrient may compensate NO synthase (NOS)-dependent NO generation through the enterosalivary nitrate-nitrite-NO pathway by transmitting NO activity in various molecular forms, including NO and protein S-nitrosothiols. Potential topics in this special issue may include the above-mentioned metabolic disorders but are not limited to the association of nitrite-mediated NO activity with lifestyle-related diseases. We would also like to extend the concept of this theme to the field of sports and exercise, maternal nutrition, breastfeeding during the perinatal period, and even to infectious diseases, including COVID-19, in which NO-mediated molecular mechanisms may be beneficially involved. In this special issue, we look forward to discussions on the prophylactic and therapeutic effects of nitrite intake as a nutrient in a variety of pathophysiological conditions.
Prof. Jun Kobayashi
Dr. Isamu Murata
Dr. Kazuo Ohtake
Dr. Kunihiro Sonoda
Guest Editors
Awards 【 display / non-display 】
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令和３年度栄養関係功労者厚生労働大臣表彰
2021.09 厚生労働省 栄養士養成功労者
小林順
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第34回日本小児循環器学会 肺高血圧症シンポジウム
1998.07 日本小児循環器学会
小林順
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第４４回日本心臓病学会学術集会 主演題 優秀賞
1996.09 日本心臓病学会
小林順
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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The Award of Medical Research Council of Canada Fellowship.
1991.07 カナダ政府
Other External Funds 【 display / non-display 】
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簡易型一酸化窒素発生装置を用いたラットクラッシュ症候群モデル救命治療に関する研究
2021.09 - 2023.08
城西大学 ２０２１年度学長所管研究
村田 勇、小林順、石原伸輔（国立研究開発法人物質・材料研究機構）
Grant type：Competitive
簡易型一酸化窒素(NO)発生装置を用いた災害現場でのクラッシュ症候群救命治療に関する研究。ラットモデルを使いNO吸入療法による治療効果並びに、他の注射用薬剤との併用による相加的、相乗的治療効果を検討すし、実用化に繋げる。
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胃液及び胃組織中のニトロソ化タンパク質の分析とその生理的機能変化に関する研究
2002.04 - 2003.03
平成14年度研究奨励金（共同研究）
小林順、内田博之、大竹一男
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肺動脈選択性一酸化窒素供与体による実験的肺高血圧症治療への応用
1999.04 - 2000.03
母子健康協会 母子健康協会第１１回医学助成研究
Grant type：Competitive
原発性肺高血圧症の治療は静注用プロスタグランデン製剤が中心となっているが、高価なこと副作用の点から、NO製剤の期待がある。しかし吸入用NOは、その毒性から医薬品として認められておらず、在宅などでの使用に制限がある。我々は静注用NOドナーとしてのGSNOの有効性を他のNOドナーと比較し、実験的肺高血圧症モデルを使って、証明した。さらに肺で選択的にガス状一酸化窒素を放出するメカニズムについても検討した。
Committee Memberships 【 display / non-display 】
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日本小児肺循環研究会 会長
2003.02
Committee type：Academic society
Media Coverage 【 display / non-display 】
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Is that a Blue Miracle? What do we know about Viagra and COVID-19? Did it really saved life? Internet
You Tube (https://www.youtube.com/watch?v=7-hKNd9x6uM) 2022.01
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The Unexpected Dangers of Mouthwash Internet
You Tube (https://www.youtube.com/watch?v=moKsVeL6sZs) 2022.05
Author：Other
Academic Activities 【 display / non-display 】
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Topic editor for ”Nitrite and Nitric Oxide in Life” International contribution
Role(s)： Supervision (editorial), Review, evaluation, Planning/Implementing academic research
Biology, Biomedicined, Current Issues in Molecular Biology, IJMS,J Mol Biol, life) 2022 - 2023
Type：peer_review_etc
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Guest editor for “Nitric Oxide Biosynthesis Pathway and Nitric Oxide Signaling in Human Diseases” International contribution
Role(s)： Review, evaluation, Planning/Implementing academic research, Peer review
International Journal of Molecular Sciences 2022 - 2023
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Guest editor of the special issue on "Nutrients and Nitrite" International contribution
Role(s)： Review, evaluation, Planning/Implementing academic research
Internationa Journal of molecular science 2020 - 2022
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Associate editor International contribution
Role(s)： Supervision (editorial), Review, evaluation
Immunoendocrinology 2015
Type：review
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A member of editorial advisory board International contribution
Role(s)： Peer review
Journal of Nutritional Medicine and Diet Care 2015
Type：peer_review_etc