論文 - 小松 周平
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Controlled phagocytosis of thermoresponsive core-corona type nanoparticles 査読あり
Akihiko Kikuchi, Masatoshi Kawase, Syuuhei Komatsu, Taka-Aki Asoh
Tissue Engineering and Regenerative Medicine International Society-AP Chapter and the 7th Asian Biomaterials Congress 2019年10月
記述言語：英語
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Drug Containing Carbonate Apatite Capsule Made from Biodegradable Coacervate Droplets for Bone Tissue Engineering 査読あり
Syuuhei KOMATSU, Taka-Aki ASOH, Akihiko KIKUCHI
Tissue Engineering and Regenerative Medicine International Society-AP Chapter and the 7th Asian Biomaterials Congress 2019年10月
担当区分：筆頭著者 記述言語：英語
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Fabrication of thermoresponsive degradable hydrogel made by radical polymerization of 2-methylene-1,3-dioxepane: Unique thermal coacervation in hydrogel 査読あり 国際誌
Syuuhei Komatsu, Taka-Aki Asoh, Ryo Ishihara, Akihiko Kikuchi
POLYMER 179 2019年09月
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Design of a surface-functionalized power-free microchip for extracellular vesicle detection utilizing UV grafting 査読あり 国際誌
R. Ishihara, A. Katagiri, T. Nakajima, R. Matsui, S. Komatsu, K. Hosokawa, M. Maeda, Y. Tomooka, A. Kikuchi
REACT FUNCT POLYM 142 183 - 188 2019年07月
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Preparation of thermo‐and redox‐responsive branched polymers composed of three‐armed oligo (ethylene glycol) 査読あり 国際誌
Syuuhei Komatsu, Hidenari Kayano, Yu Ando, Taka‐Aki Asoh, Ryo Ishihara, Akihiko Kikuchi
J POLYM SCI POL CHEM 56 ( 23 ) 2623 - 2629 2018年12月
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Controlled Phagosytosis Of Relatively Hydrophilic Core-corona Type Spherical- Or Rod-shaped Particles 査読あり
Akihiko KIKUCHI Yota KOSUKEGAWA Masatoshi KAWASE Syuuhei KOMATSU Ryo ISHIHARA Taka-Aki ASOH
2018 Controlled Release Society Annual Meeting & Exposition 2018年06月
記述言語：英語
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Organic-inorganic Hybrid Core-shell Particles Made from Biodegradable Coacervate Droplets for Bone Tissue Engineering 査読あり
Syuuhei KOMATSU , Yui Ikedo, Taka Aki ASOH, Ryo ISHIHARA, Akihiko KIKUCHI
2018 Controlled Release Society Annual Meeting & Exposition 2018年06月
担当区分：筆頭著者 記述言語：英語
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Fabrication of Hybrid Capsules via CaCO3 Crystallization on Degradable Coacervate Droplets 査読あり 国際誌
Syuuhei Komatsu, Yui Ikedo, Taka-Aki Asoh, Ryo Ishihara, Akihiko Kikuchi
Langmuir 34 ( 13 ) 3981 - 3986 2018年04月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：American Chemical Society
Organic-inorganic CaCO3 capsules were prepared by crystallization of CaCO3 on Pickering emulsion prepared using coacervate droplets made from thermoresponsive and degradable poly(2-methylene-1,3-dioxepane-co-2-hydroxyethyl acrylate) (poly(MDO-co-HEA)) in sole aqueous medium. The diameters of CaCO3-based Pickering emulsion could be controlled by varying several parameters: diameter of CaCO3 powders, initial polymer concentration, and copolymer composition. The CaCO3 Pickering emulsion was able to load low-molecular-weight hydrophobic substances at temperatures above the lower critical solution temperature (LCST) due to formation of polymer-concentrated phases, i.e., coacervate droplets. The diameter of CaCO3 capsules prepared by crystallization also depended on the diameter of the CaCO3 Pickering emulsion. The CaCO3 shell was composed of calcite-type crystals, the most stable polymorph among known CaCO3 crystals. The facially prepared CaCO3 capsules are valuable for use in functional biomaterials, such as drug delivery carriers and cell culture scaffolds for noninvasive bone-regenerative medicine.
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Facile preparation of degradable thermoresponsive polymers as biomaterials: Thermoresponsive polymers prepared by radical polymerization degrade to water-soluble oligomers 査読あり 国際誌
Syuuhei Komatsu, Taka-Aki Asoh, Ryo Ishihara, Akihiko Kikuchi
POLYMER 130 68 - 73 2017年11月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：ELSEVIER SCI LTD
A novel thermoresponsive and biodegradable polymer, poly(MDO-co-HEA), was prepared by radical copolymerization of 2-methylene-1,3-dioxepane (MDO) and a hydrophilic vinyl monomer, 2-hydroxyethyl acrylate (HEA), in dimethylsulfoxide (DMSO), varying feed monomer compositions. Poly( MDO-co-HEA) showed lower critical solution temperature (LCST)-type phase separation in aqueous medium, forming coacervate droplets into which low molecular weight hydrophobic molecules could be loaded above the LCST. The LCST could be controlled not only by the chemical compositions of the hydrophobic MDO and hydrophilic HEA in the polymer chains, but also by ion and polymer concentration. Degradation tests in aqueous media indicated that poly(MDO-co-HEA) was converted into hydrophilic oligomers by hydrolysis of the ester groups in the polymer backbone. The facile preparation poly(MDO-co-HEA) are valuable for use in functional biomedical materials, such as base of drug delivery carrier and cell culture scaffold instead of non-degradable stimuli-responsive polymer. (C) 2017 Elsevier Ltd. All rights reserved.