Details of a Researcher - UEMURA Takeshi

Papers - UEMURA Takeshi

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Urinary Amino Acid-Conjugated Acrolein and Taurine as New Biomarkers for Detection of Dementia. International journal

Madoka Yoshida, Takeshi Uemura, Mutsumi Mizoi, Masaaki Waragai, Akihiko Sakamoto, Yusuke Terui, Keiko Kashiwagi, Kazuei Igarashi

Journal of Alzheimer's disease : JAD 2023.01

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Dementia, including Alzheimer's disease (AD), is one of the serious diseases at advanced age, and its early detection is important for maintaining quality of life (QOL). OBJECTIVE: In this study, we sought novel biomarkers for dementia in urine. METHODS: Samples of urine were collected from 57 control subjects without dementia, 62 mild cognitive impairment (MCI) patients, and 42 AD patients. Mini-Mental State Examination (MMSE) was evaluated when subjects were examined by medical doctors. Urinary amino acid (lysine)-conjugated acrolein (AC-Acro) was measured using N ɛ -(3-formyl-3, 4-dehydropiperidine) lysine (FDP-Lys) ELISA kit, and taurine content was measured using a taurine assay kit. Values were normalized by creatinine content which was measured with the colorimetric assay kit. RESULTS: We found that urinary amino acid (lysine)-conjugated acrolein (AC-Acro) and taurine negatively correlated with MMSE score and are significantly lower in dementia patients compared to the normal subjects. When AC-Acro and taurine were evaluated together with age using an artificial neural network model, median relative risk values for subjects with AD, subjects with mild cognitive impairment, and control subjects were 0.96, 0.53, and 0.06, respectively. CONCLUSION: Since urine is relatively easy to collect, our findings provide a novel biomarker for dementia without invasiveness.

DOI： 10.3233/JAD-220912

PubMed

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蛋白質抱合アクロレイン、IL-6並びにCRP測定に基づく脳梗塞リスク評価による脳梗塞発症者数の減少 Reviewed

五十嵐一衛, 植村武史, 柏木敬子

未病と抗老化 2020.06

Language：Japanese

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Decrease of Patients with Brain Infarction through Evaluation of Relative Risk Value of Brain Infarction by Measurement of Protein-Conjugated Acrolein, IL-6 and CRP in Plasma Together with Age Reviewed

Takeshi Uemura, Tetsuto Kanzaki, Katsuhiko Ishizawa, Keiko Kashiwagi, Kazuei Igarashi

Biomark J 6 ( 1 ) 1 - 3 2020.02

Language：English Publishing type：Research paper (scientific journal)

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加齢による脳梗塞悪化メカニズムと新規脳梗塞予防薬の探索 Reviewed

植村武史, 渡辺健太, 柏木敬子, 五十嵐一衛

未病と抗老化 27 39 - 43 2018.11

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

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精神疾患患者における脳障害度、組織障害バイオマーカー及び薬物療法の関連

吉田円, 神崎哲人, 溝井睦美, 中村瑞穂, 植村武史, 三森盛亮, 鵜重順康, 関根慶輔, 石井千博, 吉見太朗, 安井玲子, 安川明香, 佐藤護, 岡元誠子, 久岡哲也, 三浦正史, 草西俊, 村上佳奈子, 中野知恵子, 水田康彦, 三島修一, 早川達郎, 塚田和美, 柏木敬子, 五十嵐一衛

日本薬学会年会要旨集 137年会 ( 3 ) 71 - 71 2017.03