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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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External Link |
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UEMURA Takeshi
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Degree 【 display / non-display 】
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博士（医薬学） ( 2005.03 千葉大学 )
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修士（臨床薬学） ( 2002.03 千葉大学 )
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学士（薬学） ( 2000.03 東邦大学 )
Research Interests 【 display / non-display 】
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Spermine oxidase
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Polyamine
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Polyamine transport
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senescence
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polyamine
Research Areas 【 display / non-display 】
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Life Science / Pharmaceutical analytical chemistry and physicochemistry
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Life Science / Pharmaceutical hygiene and biochemistry
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Life Science / Pharmaceutical hygiene and biochemistry
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Life Science / Molecular biology
From School 【 display / non-display 】
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Toho University Faculty of Pharmaceutical Science Graduated
1996.04 - 2000.03
Country：Japan
From Graduate School 【 display / non-display 】
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Chiba University Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
2002.04 - 2005.03
Country：Japan
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Chiba University Graduate School, Division of Pharmaceutical Sciences Master's Course Completed
2000.04 - 2002.03
Country：Japan
Studying abroad experiences 【 display / non-display 】
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2007.10 - 2012.03 University of Arizona, Arizona Cancer Center Postdoctoral Research Fellow
External Career 【 display / non-display 】
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Kyoto Prefectural University of Medicine Part-time researcher for university or other academic organization
2014.10
Country：Japan
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Chiba University Part-time researcher for university or other academic organization
2014.10 - 2021.03
Country：Japan
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株式会社アミンファーマ研究所 主任研究員
2014.10 - 2021.03
Country：Japan
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Kyoto Prefectural University of Medicine Assistant Professor
2012.04 - 2014.09
Country：Japan
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University of Arizona Arizona Cancer Center Researcher
2007.10 - 2012.03
Country：United States
Professional Memberships 【 display / non-display 】
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日本分子生物学会
2019.04
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American Society for Biochemistry and Molecular Biology
2019.02
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日本ポリアミン学会
2010.06
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日本生化学会
2004.04
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日本薬学会
2002.04
Papers 【 display / non-display 】
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Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver. Reviewed International journal
Takeshi Uemura, Yoshihisa Akasaka, Hiroshi Ikegaya
Heliyon 6 ( 9 ) e05031 - e05031 2020.09
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
The polyamines spermidine, spermine and putrescine are essential for normal cellular functions. The contents of polyamines in tissue decreased in aged mice compared to young mice. In this study, the polyamine contents and their metabolic byproduct acrolein-conjugated lysine (Nε-(3-formyl-3,4-dehydropiperidino)-lysine, FDP-Lys) in human liver tissue were measured and analyzed the correlation with age of the subjects. The putrescine and FDP-Lys levels were significantly increased with age. On the other hand, spermine level was decreased with age. Spermidine did not significantly correlate with age. The relative amount of spermine oxidase (SMOX) significantly correlated with the age of subjects whereas ornithine decarboxylase (ODC) and adenosylmethionine decarboxylase (AMD1) significantly reduced by the age. Our results suggested that an increase in oxidation and reduction in polyamine synthesis may cause the change of polyamine profile in the elderly.
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A search for acrolein scavengers among food components Reviewed
Uemura T, Uchida M, Nakamura M, Shimekake M, Sakamoto A, Terui Y, Higashi K, Ishii I, Kashiwagi K, Igarashi K.
Amino Acids 2023.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Nα-(5-Fluoro-2,4-dinitrophenyl)-L-leucinamide-derivatized LC/MS/MS Analysis of Amino Acid Enantiomers in HepG2 Cells Reviewed
Takano Y, Takahashi M, Kobayashi M, Uemura T, Furuchi T.
Chromatography 42 ( 3 ) 143 - 149 2021
Language：English Publishing type：Research paper (scientific journal)
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Structural change and degradation of cytoskeleton due to the acrolein conjugation with vimentin and actin during brain infarction. Reviewed International journal
Takeshi Uemura, Takehiro Suzuki, Kenta Ko, Mizuho Nakamura, Naoshi Dohmae, Akihiko Sakamoto, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi
Cytoskeleton (Hoboken, N.J.) 77 ( 10 ) 414 - 421 2020.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
We have found recently that dendritic spine extension is inhibited through acrolein conjugation with α- and β-tubulin proteins during brain infarction. In this current study, we looked for other acrolein-conjugated proteins in the 100,000g precipitate fraction, to clarify how cytoskeleton structure is modified by acrolein. Acrolein-conjugated proteins were sought from acrolein-treated mouse FM3A and Neuro2a cells and from tissues isolated from mouse brain infarction. It was found that vimentin was conjugated with acrolein, and the conjugated amino acid residue was Cys328, which is the only Cys residue in vimentin. It was also found that Cys207, 257, 285, and Lys118 in actin, another cytoskeleton protein, were conjugated with acrolein. The structure and localization of vimentin and actin filaments were changed greatly in infarct brain in photochemically induced thrombosis model mice and in acrolein-treated Neuro2a cells. In addition, degradation of cytoskeleton proteins was accelerated in the order vimentin > tubulin > actin in mouse brain infarction. These findings indicate that a dysfunction of the cytoskeleton by acrolein is strongly involved in the tissue damage during brain infarction, together with the apoptosis caused by glyceraldehyde-3-phosphate dehydrogenase and protein degradation by matrix metalloproteinase-9.
DOI： 10.1002/cm.21638
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Urinary Amino Acid-Conjugated Acrolein and Taurine as New Biomarkers for Detection of Dementia Reviewed
Yoshida M, Uemura T, Mizoi M, Waragai M, Sakamoto A, Terui Y, Kashiwagi K, Igarashi K.
J Alzheimers Dis. 2023.01
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
Books and Other Publications 【 display / non-display 】
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PRACTICAL基礎化学
（ Role： Contributor）
2025
Misc 【 display / non-display 】
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Thermus thermophilusのホモスペルミジン生合成に関与する新規アグマチンホモカップリング酵素の同定
小林照幸, 坂本明彦, 久野玉雄, 柏木敬子, 五十嵐一衛, 高尾浩一, 植村武史, 古地壯光, 杉田義昭, 森屋利幸, 大島泰郎, 照井祐介
日本ポリアミン学会年会プログラム及び抄録集 14th 2023
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Thermus thermophilusにおけるアルギナーゼによるプトレシンの生合成
小林照幸, 坂本明彦, 柏木敬子, 五十嵐一衛, 高尾浩一, 植村武史, 森屋利幸, 大島泰郎, 照井祐介
日本生化学会大会(Web) 96th 2023
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Putrescine biosynthesis pathways in Thermus thermophilus
小林照幸, 坂本明彦, 柏木敬子, 五十嵐一衛, 高尾浩一, 植村武史, 森屋利幸, 大島泰郎, 照井祐介
日本ポリアミン学会年会プログラム及び抄録集 13th 2023
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Identification of potential preventors for brain stroke from foods
植村武史, 植村武史, 中村瑞穂, 中村瑞穂, 坂本明彦, 照井祐介, 柏木敬子, 五十嵐一衛, 五十嵐一衛
日本薬学会年会要旨集(Web) 141st 2021
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Polyamines stimulate the synthesis of circadian clock gene at the level of translation
坂本明彦, 照井祐介, 植村武史, 植村武史, 五十嵐一衛, 五十嵐一衛, 柏木敬子
日本薬学会年会要旨集(Web) 141st 2021
Presentations 【 display / non-display 】
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Aging associated change in polyamine metabolism Invited International conference
Takeshi Uemura, Yuka Yokota, Miki Matsunaga, Yoshihisa Akasaka, Koichi Takao, Hiroshi Ikegaya, Takemitsu Furuchi
Sixth International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives 2022.09 Enzo Agostinelli
Event date： 2022.09
Language：English Presentation type：Oral presentation (general)
Venue：Tivoli, Rome Country：Italy
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Acrolein alters antigen recognition of immunoglobulin and increases matrix metalloproteinase 9 activity in primary Sjögren's syndrome patient Invited International conference
Takeshi Uemura
4th International Conference of Polyamines 2016.09
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Repression of polyamine metabolism reduces the acrolein cytotoxicity Invited International conference
Takeshi Uemura
BMB2015 2015.12
Event date： 2015.12
Language：Japanese Presentation type：Oral presentation (invited, special)
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肝臓機能におけるポリアミン代謝の役割 Invited
植村 武史
農芸化学大会 2015.03
Event date： 2015.03
Language：Japanese Presentation type：Oral presentation (invited, special)
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Regulation of cellular polyamines by transport, protein sorting and metabolism Invited
Takeshi Uemura
2013.09
Event date： 2013.09
Language：English Presentation type：Oral presentation (invited, special)
Industrial Property Rights 【 display / non-display 】
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脳血管障害および／または認知症の予防、治療および／または症状進展抑制剤
五十嵐一衛, 植村武史
Application no：特願2017-029992 Date applied：2017.02
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細胞増殖の促進によりアルコール生産効率を向上させる方法
五十嵐一衛, 柏木敬子, 立原健, 植村武史
Application no：特願2005-104316号 Date applied：2005.03
Awards 【 display / non-display 】
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博慈会 ダ・ビンチ賞
2018.11 博慈会
植村武史
Award type：Honored in official journal of a scientific society, scientific journal Country：Japan
Scientific Research Funds Acquisition Results 【 display / non-display 】
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高度好熱菌由来新規天然物カルドマイシンの抗生物質への確立と作用機序解析
Grant number：25K09900 2025.04 - 2028.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
照井 祐介, 植村 武史, 高尾 浩一
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
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Controlling the anti aging mechanism through modification of the protein translation pathway and Amine metabolizing pathway
Grant number：23K24772 2022.04 - 2025.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Grant amount：\17810000 （ Direct Cost: \13700000 、 Indirect Cost：\4110000 ）
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Controlling the anti aging mechanism through modification of the protein translation pathway and Amine metabolizing pathway
Grant number：22H03515 2022.04 - 2024.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s) Grant type：Competitive
Grant amount：\17810000 （ Direct Cost: \13700000 、 Indirect Cost：\4110000 ）
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ポリアミンが誘導するリピート病の発症機構とその制御による病態抑制効果の解明
Grant number：22K07357 2022.04 - 2024.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
小黒 明広, 今高 寛晃, 植村 武史
Authorship：Coinvestigator(s) Grant type：Competitive
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
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加齢によるスペルミン分解活性化機構解明と新規抗老化物質の創出
Grant number：22K11860 2022.04 - 2024.03
日本学術振興会 科学研究費助成事業 基盤研究(C) 基盤研究(C)
植村 武史
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Teaching Experience 【 display / non-display 】
Committee Memberships 【 display / non-display 】
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日本ポリアミン学会 評議員
2025.04
Committee type：Academic society
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日本ポリアミン学会 企画運営委員会委員、学会誌編集委員
2014.10
Committee type：Academic society