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Asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a thiourea organocatalyst 査読あり
Taro Koda, Hiroshi Akutsu, Mitsuaki Suzuki, Kosuke Nakashima, Shin-ichi Hirashima, Akihiro Yoshida, Tsuyoshi Miura, Takashi Yamanoi
Tetrahedron Letters 155 155392 - 155392 2025年01月
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Regioselective One-Pot Synthesis of Vicinal Bisphosphine Derivatives from Nitroalkenes by Hydrophosphinylation/Elimination/Hydrophosphinylation. 査読あり 国際誌
Eiki Hirota, Shin-Ichi Hirashima, Ryuki Morita, Junya Takase, Yasuyuki Matsushima, Kosuke Nakashima, Hiroshi Akutsu, Tsuyoshi Miura
Organic letters 26 ( 9 ) 1797 - 1802 2024年03月
記述言語：英語 掲載種別：研究論文（学術雑誌）
Herein, a facile method is developed for the synthesis of vicinal bisphosphine derivatives based on a cascade of hydrophosphinylation, elimination, and hydrophosphinylation of secondary phosphine oxides with nitroalkenes. This cascade reaction provides step-economy access to a series of vicinal bisphosphine derivatives with high to excellent yields (up to 99%). This method was further extended to prepare, in one-pot, regioselective vicinal bisphosphine derivatives that incorporated two different phosphorus functional groups.
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Daiki Ishii, Shin-ichi Hirashima, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Hiroshi Akutsu, Tsuyoshi Miura
Asian Journal of Organic Chemistry 2023年02月
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Daiki Ishii, Shin‐ichi Hirashima, Hiroshi Akutsu, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Tsuyoshi Miura
Asian Journal of Organic Chemistry 11 ( 5 ) 2022年03月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Wiley
Abstract
Diaminomethylenemalononitrile organocatalysts efficiently promoted the asymmetric direct vinylogous conjugate addition of α‐angelica lactone to (E)‐ and (Z)‐benzoyl acrylonitrile derivatives. The synthesized products bear vicinal tertiary and quaternary stereogenic centers with excellent enantioselectivities (up to 98% ee). This report is the first successful example of the stereoselective conjugate addition using (Z)‐benzoyl acrylonitriles as Michael acceptor.その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajoc.202200048
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Masahiro Kawada, Ryo Tsuyusaki, Kosuke Nakashima, Hiroshi Akutsu, Shin‐ichi Hirashima, Takashi Matsumoto, Hikaru Yanai, Tsuyoshi Miura
Chemistry – An Asian Journal 16 ( 16 ) 2272 - 2275 2021年08月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Wiley
その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/asia.202100487
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薬学実習Ｄ
2023年04月 - 現在
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生物有機化学演習
2022年04月 - 現在
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有機化学Ａ
2021年04月 - 現在
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薬学実習Ｅ
2021年04月 - 2024年03月
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薬学英語入門
2021年 - 現在