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Asymmetric Direct Vinylogous Conjugate Addition of α,β-Unsaturated γ-Butyrolactam to Acyl Acrylonitriles using Organocatalysts 査読あり
D. Ishii, S. Hirashima, K. Nakashima, Y. Matsushima, T. Sakai, H. Akutsu, T. Miura
Asian Journal of Organic Chemistry e202300082 2023年02月
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Daiki Ishii, Shin‐ichi Hirashima, Hiroshi Akutsu, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Tsuyoshi Miura
Asian Journal of Organic Chemistry 11 ( 5 ) 2022年03月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Wiley
Abstract
Diaminomethylenemalononitrile organocatalysts efficiently promoted the asymmetric direct vinylogous conjugate addition of α‐angelica lactone to (E)‐ and (Z)‐benzoyl acrylonitrile derivatives. The synthesized products bear vicinal tertiary and quaternary stereogenic centers with excellent enantioselectivities (up to 98% ee). This report is the first successful example of the stereoselective conjugate addition using (Z)‐benzoyl acrylonitriles as Michael acceptor.その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajoc.202200048
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Diaminomethylenemalononitrile as a Chiral Single Hydrogen Bond Catalyst: Application to Enantioselective Conjugate Addition of α‐Branched Aldehydes 査読あり
Masahiro Kawada, Ryo Tsuyusaki, Kosuke Nakashima, Hiroshi Akutsu, Shin‐ichi Hirashima, Takashi Matsumoto, Hikaru Yanai, Tsuyoshi Miura
Chemistry – An Asian Journal 16 ( 16 ) 2272 - 2275 2021年08月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Wiley
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Asymmetric Direct Vinylogous Conjugate Addition of Substituted Furanone Derivatives to Benzoyl Acrylonitrile: Stereoselective Synthesis Toward Bicyclic γ-Lactams 査読あり
Daiki Ishii, Shin-ichi Hirashima, Kosuke Nakashima, Hiroshi Akutsu, Takaaki Sakai, Yasuyuki Matsushima, Masahiro Kawada, Tsuyoshi Miura
Organic Letters 23 ( 2 ) 480 - 485 2021年01月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：American Chemical Society (ACS)
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Asymmetric Conjugate Addition of α-Cyanoketones to Benzoyl Acrylonitrile Derivatives Using a Diaminomethylenemalononitrile Organocatalyst 査読あり
Hiroshi Akutsu, Kosuke Nakashima, Yuta Kanetsuna, Masahiro Kawada, Shin-ichi Hirashima, Tsuyoshi Miura
Synthesis 52 ( 24 ) 3874 - 3880 2020年09月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Georg Thieme Verlag KG