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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Title |
Assistant Professor |
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External Link |
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AKUTSU Hiroshi
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From School 【 display / non-display 】
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Tokyo University of Pharmacy and Life Science Faculty of Pharmaceutical Science Graduated
- 2015.03
Country：Japan
From Graduate School 【 display / non-display 】
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Tokyo University of Pharmacy and Life Science Graduate School, Division of Pharmaceutical Sciences Doctor's Course Unfinished Course
2015.04 - 2018.06
Country：Japan
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Assistant Professor
2020.04
External Career 【 display / non-display 】
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Tokyo University of Pharmacy and Life Science Research Assistant
2018.07 - 2020.03
Country：Japan
Qualification Acquired 【 display / non-display 】
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Pharmacist
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Hazardous Material Handler (first kind)
Papers 【 display / non-display 】
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Asymmetric Direct Vinylogous Conjugate Addition of α,β-Unsaturated γ-Butyrolactam to Acyl Acrylonitriles using Organocatalysts Reviewed
D. Ishii, S. Hirashima, K. Nakashima, Y. Matsushima, T. Sakai, H. Akutsu, T. Miura
Asian Journal of Organic Chemistry e202300082 2023.02
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Daiki Ishii, Shin‐ichi Hirashima, Hiroshi Akutsu, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Tsuyoshi Miura
Asian Journal of Organic Chemistry 11 ( 5 ) 2022.03
Publishing type：Research paper (scientific journal) Publisher：Wiley
Abstract
Diaminomethylenemalononitrile organocatalysts efficiently promoted the asymmetric direct vinylogous conjugate addition of α‐angelica lactone to (E)‐ and (Z)‐benzoyl acrylonitrile derivatives. The synthesized products bear vicinal tertiary and quaternary stereogenic centers with excellent enantioselectivities (up to 98% ee). This report is the first successful example of the stereoselective conjugate addition using (Z)‐benzoyl acrylonitriles as Michael acceptor.Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajoc.202200048
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Diaminomethylenemalononitrile as a Chiral Single Hydrogen Bond Catalyst: Application to Enantioselective Conjugate Addition of α‐Branched Aldehydes Reviewed
Masahiro Kawada, Ryo Tsuyusaki, Kosuke Nakashima, Hiroshi Akutsu, Shin‐ichi Hirashima, Takashi Matsumoto, Hikaru Yanai, Tsuyoshi Miura
Chemistry – An Asian Journal 16 ( 16 ) 2272 - 2275 2021.08
Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
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Asymmetric Direct Vinylogous Conjugate Addition of Substituted Furanone Derivatives to Benzoyl Acrylonitrile: Stereoselective Synthesis Toward Bicyclic γ-Lactams Reviewed
Daiki Ishii, Shin-ichi Hirashima, Kosuke Nakashima, Hiroshi Akutsu, Takaaki Sakai, Yasuyuki Matsushima, Masahiro Kawada, Tsuyoshi Miura
Organic Letters 23 ( 2 ) 480 - 485 2021.01
Language：English Publishing type：Research paper (scientific journal) Publisher：American Chemical Society (ACS)
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Asymmetric Conjugate Addition of α-Cyanoketones to Benzoyl Acrylonitrile Derivatives Using a Diaminomethylenemalononitrile Organocatalyst Reviewed
Hiroshi Akutsu, Kosuke Nakashima, Yuta Kanetsuna, Masahiro Kawada, Shin-ichi Hirashima, Tsuyoshi Miura
Synthesis 52 ( 24 ) 3874 - 3880 2020.09
Language：English Publishing type：Research paper (scientific journal) Publisher：Georg Thieme Verlag KG