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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Title |
Assistant Professor |
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External Link |
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AKUTSU Hiroshi
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Research Areas 【 display / non-display 】
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Life Science / Pharmaceutical chemistry and drug development sciences
From School 【 display / non-display 】
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Tokyo University of Pharmacy and Life Science Faculty of Pharmaceutical Science Graduated
- 2015.03
Country：Japan
From Graduate School 【 display / non-display 】
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Tokyo University of Pharmacy and Life Science Graduate School, Division of Pharmaceutical Sciences Doctor's Course Unfinished Course
2015.04 - 2018.06
Country：Japan
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Assistant Professor
2020.04
External Career 【 display / non-display 】
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Tokyo University of Pharmacy and Life Science Research Assistant
2018.07 - 2020.03
Country：Japan
Qualification Acquired 【 display / non-display 】
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Pharmacist
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Hazardous Material Handler (first kind)
Papers 【 display / non-display 】
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Asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a thiourea organocatalyst Reviewed
Taro Koda, Hiroshi Akutsu, Mitsuaki Suzuki, Kosuke Nakashima, Shin-ichi Hirashima, Akihiro Yoshida, Tsuyoshi Miura, Takashi Yamanoi
Tetrahedron Letters 155 155392 - 155392 2025.01
Authorship：Corresponding author Publishing type：Research paper (scientific journal) Publisher：Elsevier BV
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Regioselective One-Pot Synthesis of Vicinal Bisphosphine Derivatives from Nitroalkenes by Hydrophosphinylation/Elimination/Hydrophosphinylation. Reviewed International journal
Eiki Hirota, Shin-Ichi Hirashima, Ryuki Morita, Junya Takase, Yasuyuki Matsushima, Kosuke Nakashima, Hiroshi Akutsu, Tsuyoshi Miura
Organic letters 26 ( 9 ) 1797 - 1802 2024.03
Language：English Publishing type：Research paper (scientific journal)
Herein, a facile method is developed for the synthesis of vicinal bisphosphine derivatives based on a cascade of hydrophosphinylation, elimination, and hydrophosphinylation of secondary phosphine oxides with nitroalkenes. This cascade reaction provides step-economy access to a series of vicinal bisphosphine derivatives with high to excellent yields (up to 99%). This method was further extended to prepare, in one-pot, regioselective vicinal bisphosphine derivatives that incorporated two different phosphorus functional groups.
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Daiki Ishii, Shin-ichi Hirashima, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Hiroshi Akutsu, Tsuyoshi Miura
Asian Journal of Organic Chemistry 2023.02
Publishing type：Research paper (scientific journal) Publisher：Wiley
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Daiki Ishii, Shin‐ichi Hirashima, Hiroshi Akutsu, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Tsuyoshi Miura
Asian Journal of Organic Chemistry 11 ( 5 ) 2022.03
Publishing type：Research paper (scientific journal) Publisher：Wiley
Abstract
Diaminomethylenemalononitrile organocatalysts efficiently promoted the asymmetric direct vinylogous conjugate addition of α‐angelica lactone to (E)‐ and (Z)‐benzoyl acrylonitrile derivatives. The synthesized products bear vicinal tertiary and quaternary stereogenic centers with excellent enantioselectivities (up to 98% ee). This report is the first successful example of the stereoselective conjugate addition using (Z)‐benzoyl acrylonitriles as Michael acceptor.Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajoc.202200048
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Masahiro Kawada, Ryo Tsuyusaki, Kosuke Nakashima, Hiroshi Akutsu, Shin‐ichi Hirashima, Takashi Matsumoto, Hikaru Yanai, Tsuyoshi Miura
Chemistry – An Asian Journal 16 ( 16 ) 2272 - 2275 2021.08
Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/asia.202100487