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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Title |
Associate Professor |
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Laboratory Address |
Josai University, bldg 21, room 423, Keyakidai 1-1, Sakado, Saitama, 350-0295, Japan |
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Laboratory Phone number |
+81-49-271-8107 |
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Laboratory Fax number |
049-271-8107 |
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Contact information |
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External Link |
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Seki Tomohiro
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Research Areas 【 display / non-display 】
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Life Science / Pharmaceutical analytical chemistry and physicochemistry
From School 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Science Graduated
2006.04 - 2012.03
Country：Japan
From Graduate School 【 display / non-display 】
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Josai University Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
2012.04 - 2016.03
Country：Japan
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Associate Professor
2024.04
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Assistant Professor
2019.04 - 2024.03
External Career 【 display / non-display 】
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National Institutes of Health Ntional Cancer Institute, Center for Cancer Research, Radiation Biology Branch Researcher
2016.07 - 2018.01
Country：United States
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National Institutes of Health Ntional Cancer Institute, Center for Cancer Research, Radiation Biology Branch
2018.02 - 2019.03
Country：United States
Professional Memberships 【 display / non-display 】
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日本薬剤学会
2012.03
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日本薬学会
2011.03
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日本DDS学会
2011.03
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日本シクロデキストリン学会
2011.03 - 2016.03
Research Career 【 display / non-display 】
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高分子ナノシートを用いたin vitro薬物膜透過評価への適用と経皮薬物送達システムへの応用
(not selected)
Project Year： 2019.04 -
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CD44陽性がん標的指向性を有するプロドラッグ型グルタチオン応答薬物放出システム
Grant-in-Aid for Scientific Research
Project Year： 2019.04 -
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インスリン製剤のアミロイド化に関する基礎的研究
(not selected)
Project Year： 2019.04 -
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動的核偏極MRIを用いた非侵襲的in vivo腫瘍代謝イメージング
(not selected)
Project Year： 2016.07 -
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糖応答性インスリン放出システムに関する
(not selected)
Project Year： 2010.04 -
Papers 【 display / non-display 】
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Sugar-sensitive supramolecular structures based on phenylboronic acid-modified cyclodextrins Reviewed International journal
Kiminobu Nakamura, Tomohiro Seki, Yuya Egawa, Ryotaro Miki, Yoshiki Oda, Takashi Yamanoi, Toshinobu Seki
Chemical and Pharmaceutical Bulletin 61 ( 11 ) 1188 - 1191 2013
Language：English Publishing type：Research paper (scientific journal) Publisher：J-Stage
Supramolecular structures were developed from phenylboronic acid-modified cyclodextrins (PBA-CyDs). The intermolecular interaction between the PBA moiety and the CyD cavity was proved using 2D NMR and powder X-ray diffraction techniques. PBA-α-CyD formed a head-to-tail supramolecular polymer, whereas PBA-β-CyD formed a head-to-head dimer. The supramolecular structures were disintegrated in the presence of sugars owing to the resulting boronate sugar interactions.
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Sugar-responsive pseudopolyrotaxanes and their application in sugar-induced release of PEGylated insulin Reviewed
Tomohiro Seki, Keigo Abe, Kiminobu Nakamura, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki
Journal of Inclusion Phenomena and Macrocyclic Chemistry 82 ( 3-4 ) 417 - 424 2015
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin Reviewed
Tomohiro Seki, Misato Namiki, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni and Toshinobu Seki
Materials 8 ( 3 ) 1341 - 1349 2015
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
We have designed a sugar-responsive pseudopolyrotaxane (PPRX) by combining phenylboronic acid-modified polyethylene glycol (PBA-PEG) and γ-cyclodextrin. Phenylboronic acid (PBA) was used as a sugar-recognition motif in the PPRX because PBA reacts with a diol portion of the sugar molecule and forms a cyclic ester. When D-fructose or D-glucose was added to a suspension of PPRX, PPRX disintegrated, depending on the concentration of the sugars. Interestingly, catechol does not show a response although catechol has a high affinity for PBA. We analyzed the response mechanism of PPRX by considering equilibria.
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A Pseudopolyrotaxane for Glucose-Responsive Insulin Release: The Effect of Binding Ability and Spatial Arrangement of Phenylboronic Acid Group Reviewed
Tomohiro Seki, Keigo Abe, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, and Toshinobu Seki
Molecular Pharmaceutics 13 ( 11 ) 3807 - 3815 2016
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
A pseudopolyrotaxane (PPRX) comprising 3-carboxy-5-nitrophenylboronic acid modified γ-cyclodextrin (NPBA-γ-CyD) and naphthalene modified polyethylene glycol (Naph-PEG) as a sugar-responsive supramolecular structure is prepared. The binding of sugar by the NPBA group induced disintegration of the Naph-PEG/NPBA-γ-CyD PPRX, allowing the components to be dissolved. The Naph-PEG/NPBA-γ-CyD PPRX exhibited better sensitivity compared to that of a PPRX based on 4-carboxyphenylboronic acid modified γ-cyclodextrin (PBA-γ-CyD). We have previously reported the unique structure of Naph-PEG/PBA-γ-CyD PPRX, which formed an inclusion complex with a single-stranded PEG chain being threaded through the γ-CyD rings, with the remaining internal space being occupied by the sugar-sensing PBA moiety from a neighboring ring, thus shielding it from sugar molecules and reducing the sugar sensitivity of the PPRX. In contrast, structural analyses in this study revealed that the sugar-sensing NPBA moiety in the Naph-PEG/NPBA-γ-CyD PPRX is not included in the neighboring NPBA-γ-CyD. This spatial arrangement and the high affinity of NPBA for sugar contributed to the improved sugar responsivity. The enhanced NPBA-γ-CyD was then applied to a PPRX containing Naph-PEG-appended insulin (Naph-PEG-Ins) that showed an improved response for glucose-induced insulin release.
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A polyrotaxane gel using boronic acid-appended γ-cyclodextrin as a hybrid cross-linker Reviewed
Wataru Uchida, Maiki Yoshikawa, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Takashi Fujihara, Yoshihiro Ishimaru, Yuya Egawa
Journal of Inclusion Phenomena and Macrocyclic Chemistry 89 ( 3-4 ) 281 - 288 2017
Language：English Publishing type：Research paper (scientific journal)
A boronic acid-appended γ-cyclodextrin (BA-CyD) was synthesized as a hybrid cross-linker of polyvinyl alcohol (PVA) to form a new type of hydrogel. The CyD moiety of BA-CyD forms an inclusion complex with the PVA chain to produce a mechanically interlocking structure. At the same time, the BA moiety of BA-CyD forms covalent bonds with the 1,3-diol moieties of PVA. On the basis of these two modes of interaction, the hybrid cross-linker connects two PVA chains, thus resulting in the formation of a hydrogel. To investigate the possibility of this hydrogel becoming the basis for an intelligent material for drug delivery, sugar-responsive drug release from the hydrogel was demonstrated.
Presentations 【 display / non-display 】
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フェニルボロン酸修飾シクロデキストリンを用い糖応答性分子ネックレスの調製
関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢
日本薬学会第131年会
Event date： 2011.03
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フェニルボロン酸修飾シクロデキストリンを用いた糖応答性ポリシュードロタキサンの調製
関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢
第27回日本Drug Delivery System学会学術集会
Event date： 2011.06
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フェニルボロン酸修飾シクロデキストリンを用いた糖存在下で崩壊するポリシュードロタキサンの調製
関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢
第28回シクロデキストリンシンポジム
Event date： 2011.09
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フェニルボロン酸修飾シクロデキストリンとポリエチレングリコールにより形成される糖応答性超分子ネックレスの構造解析
関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢
日本薬学会第132年会
Event date： 2012.03
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血糖値応答性インスリンデリバリー基剤としてのシクロデキストリン誘導体超分子
関 智宏, 江川 祐哉, 中村 公薫, 小田 慶喜, 山ノ井 孝, 関 俊暢
日本薬剤学会第27年会
Event date： 2012.05
Awards 【 display / non-display 】
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最優秀発表者賞
2011.08 城西大学
関 智宏
Country：Japan
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ポスター賞
2013.09 第30回シクロデキストリンシンポジウム (日本シクロデキストリン学会)
関 智宏
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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優秀発表賞
2014.03 日本薬学会 第134年会
関 智宏
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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Most Impressive Debater賞
2014.05 日本薬剤学会第29年会
関 智宏
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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若手研究奨励賞
2014.07 物理系薬学部会 (フィジカルファーマフォーラム2014)
関 智宏
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Scientific Research Funds Acquisition Results 【 display / non-display 】
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CD44陽性がん標的指向性を有するプロドラッグ型グルタチオン応答薬物放出システム
Grant number：20K16421 2020.04 - 2023.03
科学研究費補助金 若手研究
Authorship：Principal investigator
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CD44がん標的能とエンドソーム脱出能を持つグルタチオン応答プロドラッグ型DDS
Grant number：23K14660 2023.04 - 2026.03
科学研究費補助金 若手研究
Authorship：Principal investigator
Committee Memberships 【 display / non-display 】
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日本薬剤学会 第30回日本薬剤学会学生主催シンポジウムSNPEE2015 委員
2015.05 - 2016.05
Committee type：Academic society
Social Activities 【 display / non-display 】
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埼玉県立岩槻高校 模擬授業 「からだの中での薬の運命」
Role(s)： Lecturer
埼玉県立岩槻高校 2020.11
Audience： High school students
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叡明高校 模擬授業 「からだの中での薬の運命」
Role(s)： Lecturer
2021.12
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埼玉県立小川高校 模擬授業 「からだの中での薬の運命」
Role(s)： Lecturer
2023.11
Type：Visiting lecture