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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry |
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Title |
Assistant Professor |
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External Link |
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KAMAUCHI Hitoshi
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Research Areas 【 display / non-display 】
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Life Science / Environmental and natural pharmaceutical resources
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Life Science / Pharmaceutical chemistry and drug development sciences
From School 【 display / non-display 】
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Meiji Pharmaceutical University Faculty of Pharmaceutical Science Graduated
2006.04 - 2010.03
Country：Japan
From Graduate School 【 display / non-display 】
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
2015.04 - 2018.03
Country：Japan
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Master's Course Completed
2013.04 - 2015.03
Country：Japan
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Assistant Professor
2022.04
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Research Assistant
2018.04 - 2022.03
External Career 【 display / non-display 】
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Meiji Pharmaceutical University Researcher
2011.04 - 2013.03
Country：Japan
Professional Memberships 【 display / non-display 】
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有機合成化学協会
2018.11
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日本薬学会
2013.04
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日本生薬学会
2013.04
Papers 【 display / non-display 】
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Synthesis of Daldinans and Dynamic Stereochemistry of their Atropisomers Reviewed
Hitoshi Kamauchi, Miki Goto, Yoshiaki Sugita
The Journal of Organic Chemistry in press 2024.06
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Koichi Takao, Yuka Kubota, Kota Kurosaki, Hitoshi Kamauchi, Yoshihiro Uesawa, Yoshiaki Sugita
Chemical and Pharmaceutical Bulletin 72 ( 1 ) 109 - 120 2024.01
Publishing type：Research paper (scientific journal) Publisher：Pharmaceutical Society of Japan
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A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus Curvularia aeria Reviewed
Hitoshi Kamauchi, Mayu Tanaka, Mitsuaki Suzuki, Miho Furukawa, Atsushi Ikeda, Chihiro Sasho, Yuka Kiba, Masashi Kitamura, Koichi Takao, Yoshiaki Sugita
Chemical and Pharmaceutical Bulletin 72 ( 1 ) 98 - 101 2024.01
Authorship：Lead author, Corresponding author Publishing type：Research paper (scientific journal) Publisher：Pharmaceutical Society of Japan
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Synthesis of 2,8-Dioxabicyclo[3.3.1]nonane Derivatives and Their Neuroprotective Activities Reviewed
Hitoshi Kamauchi, Akifumi Takanashi, Mitsuaki Suzuki, Kouki Izumi, Koichi Takao, Yoshiaki Sugita
Chemical and Pharmaceutical Bulletin 72 ( 1 ) 56 - 60 2024.01
Authorship：Lead author, Corresponding author Publishing type：Research paper (scientific journal) Publisher：Pharmaceutical Society of Japan
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Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains. International journal
Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Hitoshi Kamauchi, Taishi Seki, Ryuichiro Suzuki, Masashi Kitamura
Biomedicine & pharmacotherapy 169 115940 - 115940 2023.11
Language：English Publishing type：Research paper (scientific journal)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread as a pandemic and caused damage to people's lives and countries' economies. The spike (S) protein of SARS-CoV-2 contains a cleavage motif, Arg-X-X-Arg, for furin and furin-like enzymes at the boundary of the S1/S2 subunits. Given that cleavage plays a crucial role in S protein activation and viral entry, the cleavage motif was selected as the target. Our previous fluorogenic substrate study showed that osthole, a coumarin compound, inhibits furin-like enzyme activity. In this study, we examined the potential activities of 15 compounds with a structure-activity relationship with osthole, and evaluated their protective ability against SARS-CoV-2 infection. Of the 15 compounds tested, compounds C1 and C2 exhibited the inhibitory effects of osthole against furin-like enzymatic activity; however, little or no inhibitory effects against furin activity were observed. We further examined the inhibition of SARS-CoV-2 activity by compounds C1 and C2 using a Vero E6 cell line that expresses the transmembrane protease serine 2 (TMPRSS2). Compounds C1, C2, and osthole effectively inhibited SARS-CoV-2 infection. Therefore, osthole and its derivatives can potentially be used as therapeutic agents against SARS-CoV-2.
Misc 【 display / non-display 】
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Discovery of Medicinal Seeds from Chemically Engineered Extracts Invited Reviewed
Journal of Synthetic Organic Chemistry, Japan 77 ( 9 ) 895 - 903 2019.09
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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エンドファイト; 特殊環境が生み出す可能性 Invited Reviewed
鎌内 等
ファルマシア 49 ( 4 ) 333 2013.04
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益社団法人日本薬学会
Presentations 【 display / non-display 】
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菌糸-バイオフィルム形成阻害をターゲットとした真菌由来天然物の誘導体合成
鎌内 等, 木村 由, 牛渡 美琴, 關 大志, 鈴木 光明, 平田 桃香, 高尾 浩一, 杉田 義昭
第63回天然有機化合物討論会 2021.09
Event date： 2021.09
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芳香族-テルペノイド天然物の誘導体合成と神経保護作用の評価
鎌内 等, 小田 拓未, 堀内 加奈世, 高尾 浩一, 杉田 義昭
第61回天然有機化合物討論会 2019.09
Event date： 2019.09
Awards 【 display / non-display 】
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長井記念若手薬学研究者賞
2023.03 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成28年度長井記念薬学研究奨励支援
2016 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Scientific Research Funds Acquisition Results 【 display / non-display 】
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天然由来化合物を基盤とした菌糸形成阻害による「予防的」抗真菌薬の開発
Grant number：20K16029 2020.04 - 2023.03
科学研究費助成事業 若手研究
鎌内等
Authorship：Principal investigator Grant type：Competitive