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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry |
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Title |
Assistant Professor |
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External Link |
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KAMAUCHI Hitoshi
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Research Areas 【 display / non-display 】
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Life Science / Environmental and natural pharmaceutical resources
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Life Science / Pharmaceutical chemistry and drug development sciences
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Life Science / Pharmaceutical chemistry and drug development sciences
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Life Science / Environmental and natural pharmaceutical resources
From School 【 display / non-display 】
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Meiji Pharmaceutical University Faculty of Pharmaceutical Science Graduated
2006.04 - 2010.03
Country：Japan
From Graduate School 【 display / non-display 】
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
2015.04 - 2018.03
Country：Japan
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
2015.04 - 2018.03
Country：Japan
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
2013.04 - 2015.03
Country：Japan
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Master's Course Completed
2013.04 - 2015.03
Country：Japan
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Meiji Pharmaceutical University Faculty of Pharmaceutical Science Doctor's Course Completed
2006.04 - 2010.03
Country：Japan
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Assistant Professor
2022.04
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Research Assistant
2018.04 - 2022.03
External Career 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Assistant Professor
2022.04
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Research Assistant
2018.04 - 2022.03
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Meiji Pharmaceutical University Researcher
2011.04 - 2013.03
Country：Japan
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Meiji Pharmaceutical University Faculty of Pharmacy Researcher
2011.04 - 2013.03
Professional Memberships 【 display / non-display 】
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有機合成化学協会
2018.11
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日本薬学会
2013.04
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日本生薬学会
2013.04
Papers 【 display / non-display 】
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Hitoshi Kamauchi, Momoka Hirata, Koichi Takao, Yoshiaki Sugita
ACS Omaga 7 ( 45 ) 41804 - 41814 2022.11
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：American Chemical Society (ACS)
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Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells. Reviewed International journal
Hitoshi Kamauchi, Miho Furukawa, Yuka Kiba, Masashi Kitamura, Kanako Usui, Masanori Katakura, Koichi Takao, Yoshiaki Sugita
The Journal of Antibiotics 75 530 - 533 2022.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
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A Benzaldehyde Derivative Obtained from Hypoxylon truncatum NBRC 32353 Treated with Hygromycin B Reviewed International journal
Hitoshi Kamauchi, Mitsuaki Suzuki, Koichi Takao, Yoshiaki Sugita
The Journal of Antibiotics 75 1 - 8 2021.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
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Inhibition of BACE1 and Amyloid‑β Aggregation by Meroterpenoids from the Mushroom Albatrellus yasudae Reviewed International journal
Youki Masuda, Koji Fujihara, Satoshi Hayashi, Hiroaki Sasaki, Yoshihiro Kino, Hitoshi Kamauchi, Masahiro Noji, Jun-ichi Satoh, Toshikatsu Takanami, Kaoru Kinoshita, Kiyotaka Koyama
Journal of Natural Products 84 1748 - 1754 2021.06
Language：English Publishing type：Research paper (scientific journal) Publisher：ACS Publications
To develop drugs to treat Alzheimer's disease (AD) on the basis of the amyloid cascade hypothesis, the amyloid-β (Aβ) aggregation inhibitory activities of 110 extracts from mushrooms were evaluated by thioflavin T (Th-T) assays. The MeOH extract of Albatrellus yasudae inhibited Aβ aggregation, and the bioactivity-guided fractionation of the extract afforded four novel meroterpenoids, named scutigeric acid (1), albatrelactone methyl ester (2), albatrelactone (3), and 10',11'-dihydroxygrifolic acid (4), together with two known compounds, grifolin (5) and grifolic acid (6). The structures of 1-4 were elucidated using NMR, MS, UV, IR, and induced ECD spectral data. The structure of 1 was determined as a methyl ester (1a) by 2D NMR spectroscopy. Th-T assays showed that compounds 1-4 and 1a possessed inhibitory activities against Aβ aggregation, with IC50 values of 6.6, 40.7, 51.4, 53.3, and 50.3 μM, respectively. Notably, 1 possessed an inhibitory activity against Aβ aggregation comparable to that of myricetin as a positive control. Moreover, 1-6 exhibited inhibitory activities against BACE1, with IC50 values of 1.6, 10.9, 10.5, 34.4, 6.1, and 1.4 μM, respectively.
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Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors Reviewed International journal
Koichi Takao, Yuri Takemura, Junko Nagai, Hitoshi Kamauchi, Kaori Hoshi, Ryo Mabashi, Yoshihiro Uesawa, Yoshiaki Sugita
Bioorganic and Medicinal Chemistry 42 116255 - 116255 2021.06
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Inc.
A series of 3-styrylchromone derivatives was synthesized and evaluated for monoamine oxidase (MAO) A and B inhibitory activities. Most of all derivatives inhibited MAO-B selectively, except compound 21. Compound 19, which had a methoxy group at R2 on the chromone ring and chlorine at R4 on phenyl ring, potently inhibited MAO-B, with an IC50 value of 2.2 nM. Compound 1 showed the highest MAO-B selectivity, with a selectivity index of >3700. Further analysis of these compounds indicated that compounds 1 and 19 were reversible and mixed-type MAO-B inhibitors, suggesting that their mode of action may be through tight-binding inhibition to MAO-B. Quantitative structure-activity relationship (QSAR) analyses of the 3-styrylchromone derivatives were conducted using their pIC50 values, through Molecular Operating Environment (MOE) and Dragon. There were 1796 descriptors of MAO-B inhibitory activity, which showed significant correlations (P < 0.05). Further investigation of the 3-styrylchromone structures as useful scaffolds was performed through three-dimensional-QSAR studies using AutoGPA, which is based on the molecular field analysis algorithm using MOE. The MAO-B inhibitory activity model constructed using pIC50 value index exhibited a determination coefficients (R2) of 0.972 and a Leave-One-Out cross-validated determination coefficients (Q2) of 0.914. These data suggest that the 3-styrylchromone derivatives assessed herein may be suitable for the design and development of novel MAO inhibitors.
Misc 【 display / non-display 】
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Discovery of Medicinal Seeds from Chemically Engineered Extracts Invited Reviewed
Journal of Synthetic Organic Chemistry, Japan 77 ( 9 ) 895 - 903 2019.09
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Discovery of Medicinal Seeds from Chemically Engineered Extracts Invited Reviewed
Journal of Synthetic Organic Chemistry, Japan 77 ( 9 ) 895 - 903 2019.09
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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エンドファイト; 特殊環境が生み出す可能性 Invited Reviewed
鎌内 等
ファルマシア 49 ( 4 ) 333 2013.04
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益社団法人日本薬学会
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エンドファイト; 特殊環境が生み出す可能性 Invited Reviewed
鎌内 等
ファルマシア 49 ( 4 ) 333 - 333 2013.04
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益社団法人日本薬学会
Awards 【 display / non-display 】
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長井記念若手薬学研究者賞
2023.03 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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長井記念若手薬学研究者賞
2023.03 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成28年度長井記念薬学研究奨励支援
2016 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成28年度長井記念薬学研究奨励支援
2016 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Scientific Research Funds Acquisition Results 【 display / non-display 】
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天然由来化合物を基盤とした菌糸形成阻害による「予防的」抗真菌薬の開発
2020.01 - 2023.03
科学研究費補助金 若手研究
鎌内等