Papers - KIMIRA Yoshifumi
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彩の国連携力育成プロジェクトにおけるオンラインシステムを活用した多職種連携教育（チーム演習） Reviewed
村田 勇, 古屋 牧子, 堀井 徳光, 岩田 直洋, 大嶋 繁, 水野 文夫, 高尾 浩一, 小糸 寿美, 矢島 克彦, 君羅 好史, 五十嵐 庸, 柴﨑 智美, 田口 孝行, 勝木 祐仁, 細谷 治, 上田 秀雄
城西大学教職課程センター紀要 9 2025.03
Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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おしぼりの快適感をもたらす内分泌ホルモンの検証 Reviewed
下澤 達雄, 小此木 正信, 布施 宏昭, 小野 麗美, 丸山 俊昭, 大澤 吉弘, 君羅 好史, 加藤 勇太, 岩田, 直洋, 荒井, 健, 織田, 準一, 真野 博, 武山 健一
日本未病学会雑誌 30 ( 2 ) 9 - 15 2024.08
Language：Japanese Publishing type：Research paper (scientific journal)
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Kaho Nomura, Yoshifumi Kimira, Ryosuke Kobayashi, Yuna Shiobara, Yoshihiro Osawa, Aya Kataoka-Matsushita, Jun Shimizu, Masahiro Wada, Hiroshi Mano
Front. Nutr. 2024.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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活性型コラーゲンペプチドPro-Hypの筋骨格系への作用〜第100回箱根駅伝大会総合3位の城西大学男子駅伝部に対するコラーゲンペプチドによるサポート〜 Invited Reviewed
真野博, 野村佳歩, 大澤吉弘, 君羅好史
皮革科学 70 ( 1 ) 1 - 6 2024.04
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)
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Yoshifumi Kimira, Konosuke Osawa, Yoshihiro Osawa, Hiroshi Mano
Biomolecules 13 ( 11 ) 1617 - 1617 2023.11
Authorship：Lead author, Corresponding author Publishing type：Research paper (scientific journal) Publisher：MDPI AG
Glucocorticoids, commonly used to manage inflammatory diseases, can induce muscle atrophy by accelerating the breakdown of muscle proteins. This research delves into the influence of Prolyl-hydroxyproline (Pro-Hyp), a collagen-derived peptide, on muscle atrophy induced with dexamethasone (DEX), a synthetic glucocorticoid, in mouse C2C12 skeletal myotubes. Exposure to DEX (10 μM) for 6 days resulted in a decrease in myotube diameter, along with elevated mRNA and protein levels of two muscle-atrophy-related ubiquitin ligases, muscle atrophy F-box (MAFbx, also known as atrogin-1) and muscle ring finger 1 (MuRF-1). Remarkably, treatment with 0.1 mM of Pro-Hyp mitigated the reduction in myotube thickness caused by DEX, while promoting the phosphorylation of Akt, mammalian target of rapamycin (mTOR), and forkhead box O3a (Foxo3a). This led to the inhibition of the upregulation of the ubiquitin ligases atrogin-1 and MuRF-1. These findings indicate the potential significance of Pro-Hyp as a promising therapeutic target for countering DEX-induced muscle atrophy.
DOI： 10.3390/biom13111617
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Collagen-Derived Dipeptide Pro-Hyp Enhanced ATDC5 Chondrocyte Differentiation under Hypoxic Conditions Reviewed International journal
Yoshifumi Kimira , Takahiro Sato , Mayu Sakamoto , Yoshihiro Osawa , Hiroshi Mano
Molecules 28 ( 14 ) 4664 2023.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Reconstruction of alveolar cleft by recombinant type I collagen peptide particles. Reviewed
Mikiko Mano, Yoshifumi Kimira, Akiko Sugiyama, Hiroshi Mano, Naoto Suda
The Journal of Meikai Dental Medicine 52 ( 1 ) 27 - 33 2023.02
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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城西大学坂戸キャンパス周辺の湧水を起源とする水環境
真野 博, 石黒 直哉, 加藤 優斗, 中澤 秀道, 石田 美咲乃, 戸井田 和希, 稲垣 喜弘, 萩原 章, 河合 清, 小西 修也, 松田 映子, 石崎 光一, 林 弥生子, 石井 邦夫, 中西 一至, 真野 樹子, 大澤 吉弘, 君羅 好史, 松本 明世
地域と大学 2 102 - 112 2022.03
Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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Kaho Nomura, Yoshifumi Kimira, Yoshihiro Osawa, Aya Kataoka-Matsushita, Koichi Takao, Yoshiaki Sugita, Jun Shimizu, Masahiro Wada, Hiroshi Mano
Bioscience Reports 2021.11
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1042/BSR20210304.
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保険薬局・ドラッグストアに勤務する管理栄養士・栄養士の配置状況と就業の実態 Reviewed
堀由美子,内田博之,清水純,君羅好史, 小口淳美,真野博
栄養学雑誌 2021.08
Language：Japanese Publishing type：Research paper (scientific journal)
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Yoshihiro Osawa , Kaho Nomura , Yoshifumi Kimira , Seiji Kushibe , Ken-Ichi Takeyama , Masashi Nagao , Aya Kataoka-Matsushita , Seiko Koizumi , Hiroshi Mano
Scientific reports 11 ( 1 ) 13527 - 13527 2021.06
Language：English Publishing type：Research paper (scientific journal) Publisher：nature
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運動器におけるコラーゲンペプチドの機能性 Invited Reviewed
君羅好史、大澤吉弘、真野博
機能性食品と薬理栄養 14 ( 5 ) 2021.04
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本機能性食品医用学会
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荒川水系高麗川支流スミガマヤツの谷戸を利用する哺乳類について Reviewed
野村佳歩、大澤吉弘、沼澤香織、大澤奈々、真野 樹子、君羅好史、松本明世、真野 博、藤田宏之
川博紀要 21 21 - 28 2021.03
Language：Japanese Publishing type：Research paper (scientific journal)
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越生町の固有品種「べに梅」果実の科学的特徴 Reviewed
飯塚 讓、金 賢珠、松本 明世、君羅 好史、清水 純、真野 博
城西大学・城西短期大学地域連携センター紀要 1 16 - 21 2021.03
Language：Japanese Publishing type：Research paper (scientific journal)
Other Link： https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-24362336-0104
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Components and Food Function of Yuzu (Citrus junos) Fruit Whole Paste Reviewed
NOMURA Kaho, KIMIRA yoshifumi, YAMAZAKI Yuki, IIZUKA Yuzuru, ENDO Hirokatsu, KIM Hyounju, MATSUMOTO Akiyo, MANO Hiroshi
Food Preservation Science 47 ( 1 ) 31 - 9 2021.03
Language：English Publishing type：Research paper (scientific journal)
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Erucic Acid-Rich Yellow Mustard Oil Improves Insulin Resistance in KK-Ay Mice Reviewed
Asako Takahashi, Mayu Ishizaki, Yoshifumi Kimira, Yukari Egashira and Shizuka Hirai
Molecules 26 ( 3 ) 2021.01
Language：English Publishing type：Research paper (scientific journal)
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荒川水系高麗川多和目橋下流のワンドを利用するアライグマとタヌキの行動 Reviewed
野村佳歩、小林由希、谷内友梨、清水美好、大平はる香、大山恵里奈、小久保啓、小林亮介、小田桐康紘、 大澤吉弘、君羅好史、松本明世、真野 博、藤田宏之
川博紀要 20 9 - 16 2020.04
Language：Japanese Publishing type：Research paper (scientific journal)
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運動器に対するコラーゲンペプチドの効果とその作用メカニズム Reviewed
君羅好史、大澤吉弘、野村佳歩、真野博
食品加工技術 39 ( 3 ) 31 - 37 2020.02
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本食品・機械研究会
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The effects of collagen peptide supplementation on knee joint health: a double-blind, placebo-controlled, randomized trial in healthy university students belonging to a running club Reviewed
Yoshifumi Kimira, Masafumi Saito, Seiji Kushibe, Kaho Nomura, Yoshihiro Osawa, Yusuke Sekiguchi, Jun Shimizu, Sachie Nakatani, Seiko Koizumi, Naoki Inoue, Yoshihisa Mori, Jun Kobayashi, Hiroshi Mano
Jpn Pharmacol Ther 47 ( 9 ) 1455 - 1462 2019.09
Language：English Publishing type：Research paper (scientific journal)
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Kaho Nomura, Yoshifumi Kimira, Yoshihiro Osawa, Jun Shimizu, Aya Matsusita-Kataoka, Hiroshi Mano
Bioscience, Biotechnology, and Biochemistry in press 2019.07
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)