論文 - 藤堂 浩明
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In Silico Estimation of Skin Concentration of Dermally Metabolized Chemicals 査読あり
Tomomi Hatanaka, Saki Yamamoto, Mayuko Kamei, Wesam R Kadhum, Hiroaki Todo and Kenji Sugibayashi
International Journal of Pharmaceutical Sciences and Developmental Research 2017年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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A useful technique using imaging mass spectrometry for detecting the skin distribution of topically applied lidocaine 査読あり
Shosho Kijima, Hiroaki Todo, Yumi Matsumoto, Ryosuke Masaki, Wesam R. Kadhum, Kenji Sugibayashi
Journal of Drug Delivery Science and Technology 33 157 - 163 2016年06月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Effect of Combination of Low-Frequency Sonophoresis or Electroporation with Iontophoresis on the Mannitol Flux or Electroosmosis through Excised Skin 査読あり
Tokumoto S, Higo N, Todo H, Sugibayashi K
Biol Pharm Bull 2016年01月
担当区分：第二著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Risk assessment of skin lightening cosmetics containing hydroquinone., Regul Toxicol Pharmacol. 査読あり
Matsumoto M, Todo H, Akiyama T, Hirata-Koizumi M, Sugibayashi K, Ikarashi Y, Ono A, Hirose A, Yokoyama K.
Regul Toxicol Pharmacol. 2016年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Effect of Esters on the Permeation of Chemicals with Different Polarities through Synthetic Artificial Membranes Using a High-Throughput Diffusion Cell Array. 査読あり
Uchida T, Nishioka K, Motoki A, Yakumaru M, Sano T, Todo H, Sugibayashi K
Chem Pharm Bull (Tokyo) 2016年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals 査読あり
Mohd F, Todo H, Yoshimoto M, Yusuf E, Sugibayashi K
Pharmaceutics 2016年01月
担当区分：第二著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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In Vitro Permeation and Skin Retention of α-Mangostin Proniosome, 査読あり
Chin GS, Todo H, Kadhum WR, Hamid MA, Sugibayashi K
Chem Pharm Bull (Tokyo) 2016年01月
担当区分：第二著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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A Novel Chemical Enhancer Approach for Transdermal Drug Delivery with C17-Monoglycerol Ester Liquid Crystal-forming Lipid 査読あり
Kadhum WR, Sekiguchi S, Hijikuro I, Todo H, Sugibayashi K.
J Oleo Sci 2016年01月
担当区分：第二著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Evaluation of a Silicone Membrane as an Alternative to Human Skin for Determining Skin Permeation Parameters of Chemical Compounds 査読あり
Uchida T, Yakumaru M, Nishioka K, Higashi Y, Sano T, Todo H, Sugibayashi K
Chem Pharm Bull (Tokyo) 2016年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Usefulness of liquid-crystal oral formulations to enhance the bioavailability and skin tissue targeting of p-amino benzoic acid as a model compound 査読あり
Kadhum WR, Oshizaka T, Ichiro H, Todo H, Sugibayashi K
Eur J Pharm Sci 2016年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals. 査読あり
Tomomi Hatanaka, Shun Yoshida, Wesam R Kadhum, Hiroaki Todo, Kenji Sugibayashi
Pharmaceutical research 32 ( 12 ) 3965 - 3974 2015年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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A new approach for evaluating cellular damage by measuring calcium level with Fura-2 acetoxymethyl ester (Fura-2-AM) 査読あり
Wesam R. Kadhum, Manami Mitsuyama, Toru Tanaka, Hiroaki Todo, Kazuhiko, Juni, Kenji Sugibayashi,
Alternatives to Animal Testing and EXperimentation 2015年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals 査読あり
Hatanaka T, Yoshida S, Kadhum WR, Todo H, Sugibayashi K
Pharm Res 2015年07月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Prediction of skin permeation by chemical compounds using the artificial membrane, Strat-M™. 査読あり
Takashi Uchida, Wesam R Kadhum, Sayumi Kanai, Hiroaki Todo, Takeshi Oshizaka, Kenji Sugibayashi
European journal of pharmaceutical sciences 67 113 - 118 2015年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Determination of permeation pathways of clindamycin phosphate into the skin, 査読あり
Fadli A., Mohammad Nizam A. G.,Ibrahim A., Kavitha M., Jiyauddin K., Samer, A. D., S. Budiasih, M. Kaleemullah ,Jawad A., Rasha S., Todo H., Sugibayashi K., Eddy Y.
Am. J. PharmTech. Res., 2015年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Potential of imaging analysis in establishing skin concentration-distance profiles for topically applied FITC-dextran 4 kDa 査読あり
Shosho Kijima, Ryosuke Masaki, Wesam R. Kadhum, Hiroaki Todo, Tomomi Hatanaka, Kenji Sugibayashi,
ADMET and DMPK 2015年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Molecular mechanisms of action of different concentrations of ethanol in water on ordered structures of intercellular lipids and soft keratin in the stratum corneum 査読あり
1. D. Horita, H., I. Hatta, M Yoshimoto, Y. Kitao, H. Todo, K. Sugibayashi
BBA – Biomembranes 2015年
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Formulation of Tetracycline nano-emulsion 査読あり
Fadli A., Nizam A. G., Ibrahim A. , Nurulnadiah A. K., Jiyauddin K., Samer A. D., S. Budiasih, M. Kaleemullah, Jawad A., Rasha S., Todo H., Sugibayashi K. and Eddy Y.
WJPR 2015年
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Determination of permeation of pathway of Gentamicin into pig’s ear skin 査読あり
Fadli A., Jiyauddin K., Siti Nur S. J., Samer A. D., S. Budiasih, Jawad A., M. Kaleemullah, Rasha S., Mohammad Nizam A. G., Ibrahim A., Todo H., Sugibayashi K. and Eddy Y.
IRJP 2015年
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Estimation of skin concentrations of topically applied lidocaine at each depth profile.
Oshizaka Takeshi, Kikuchi Keisuke, Kadhum Wesam R, Todo Hiroaki, Hatanaka Tomomi, Wierzba Konstanty, Sugibayashi Kenji
Int J Pharm 475 ( 1-2 ) 292 - 297 2014年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
Skin concentrations of topically administered compounds need to be considered in order to evaluate their efficacies and toxicities. This study investigated the relationship between the skin permeation and concentrations of compounds, and also predicted the skin concentrations of these compounds using their permeation parameters. Full-thickness skin or stripped skin from pig ears was set on a vertical-type diffusion cell, and lidocaine (LID) solution was applied to the stratum corneum (SC) in order to determine in vitro skin permeability. Permeation parameters were obtained based on Fick's second law of diffusion. LID concentrations at each depth of the SC were measured using tape-stripping. Concentration-depth profiles were obtained from viable epidermis and dermis (VED) by analyzing horizontal sections. The corresponding skin concentration at each depth was calculated based on Fick's law using permeation parameters and then compared with the observed value. The steady state LID concentrations decreased linearly as the site became deeper in SC or VED. The calculated concentration-depth profiles of the SC and VED were almost identical to the observed profiles. The compound concentration at each depth could be easily predicted in the skin using diffusion equations and skin permeation data. Thus, this method was considered to be useful for promoting the efficient preparation of topically applied drugs and cosmetics.