論文 - 小林 順
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Nitric oxide bioavailability for red blood cell deformability in the microcirculation: A review of recent progress. 査読あり
Jun Kobayashi, Kazuo Ohtake, Isamu Murata, Kunihiro Sonoda.
Nitric Oxide, 129 25 - 29 2022年10月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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薗田 邦博、河野 有華、大竹 一男、清水 彩子、柴 祥子、飯野 汐里、加園 恵三、小林 順
金城学院大学論集自然科学編 2024 2024年09月
担当区分：最終著者
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L-NAME誘発性高血圧ラットの内皮機能不全と心臓リモデリングに対する魚油摂取の効果
薗田 邦博、河野 有華、大竹 一男、竹之内 康広、柴 祥子、小林 順、加園 恵三
金城学院大学消費生活科学研究所紀要 2024年03月
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英国と日本国内のビートルートジュースに含まれる硝酸塩と抗酸化能(ORAC値）の比較 査読あり
河野有華、薗田邦博、清水彩子、大竹一男、飯野汐里、柴祥子、小林順
金城学院大学論集 自然科学編 20 ( 1 ) 26 - 33 2023年09月
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異なるジューサーを用いて作製した野菜果物ジュースの硝酸塩含有量と官能検査の比較 査読あり
薗田邦博、河野有華、清水彩子、大竹一男、柴祥子、加園恵三、小林 順
金城学院大学消費生活科学研究所紀要 27 ( 1 ) 11 - 20 2023年03月
担当区分：最終著者 記述言語：日本語 掲載種別：研究論文（大学，研究機関等紀要）
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非アルコール性脂肪肝炎モデル動物の肝炎と肝線維化に対するSodium nitriteとCaptoprilの併用投与による影響 査読あり
河野有華、 薗田邦博、大竹一男、柴祥子、北森一哉、小林順
金城学院大学消費生活科学研究所紀要 27 ( 1 ) 1 - 10 2023年03月
担当区分：最終著者 記述言語：日本語 掲載種別：研究論文（大学，研究機関等紀要）
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Salvianolic acid B improves the survival rate, acute kidney dysfunction, inflammation and NETosis‑mediated antibacterial action in a crush syndrome rat model 査読あり
Isamu Murata, Tsugumi Sugai,Yumiko Murakawa,Yoshiaki Miyamoto, Jun Kobayashi, Yutaka Inoue, Ikuo Kanamoto
Experimental and Therapeutic Medicine 23 ( 5 ) 2022年05月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：SPAMDIDOS PUBLICATIONS
Crush syndrome (CS) is a potentially lethal condition characterized by muscle cell damage resulting from decompression following compression. Patients with CS can develop cardiac failure, kidney dysfunction, shock, systemic inflammation and sepsis. Salvianolic acid B (SalB) has cardiac and kidney protective effects and anti‑oxidative, anti‑inflammatory, anti‑apoptotic and anti‑bacterial properties. The present study aimed to demonstrate the survival benefit of SalB in the CS rat model, which comprised anesthetized rats with bilateral hindlimb compression by a rubber tourniquet for 5 h. The rats examined were randomly divided into four groups: i) Sham; ii) sham treated with SalB; iii) CS rat model without treatment; and iv) CS rat model treated with SalB. Under continuous monitoring and recording of arterial blood pressures, blood and tissue samples were collected for biochemical analyses at designated timepoints before and after reperfusion. SalB administration improved the survival rate, kidney function (by treating shock and metabolic acidosis) and inflammation (by reducing mitochondrial dysfunction and endothelial damage). Reduced incidence of cardiac failure due to hyperkalemia was associated with reduced muscle injury via the prevention of mitochondrial dysfunction. Additionally, indirect antibacterial action by the neutrophil extracellular trap system (NETs) was observed. SalB administration to the CS rat model led to a substantial improvement in survival following CS by decreasing kidney and cardiac dysfunctions, inflammation, and endothelial dysfunction by improving the mitochondrial function and through antibacterial effects via NETs.
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Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study 査読あり
Kunihiro Sonoda,Yuka Kono,Kazuya Kitamori,Kazuo Ohtake,Sachiko Shiba,Keizo Kasono and Jun Kobayashi
International Journal of Molecular Sciences 23 ( 6 ) 1 - 16 2022年03月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：MDPI
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the liver and the cardiovascular system. Here, we evaluated the effect of dietary nitrite on a rat NASH model. Stroke-prone, spontaneously hypertensive 5/Dmcr rats were fed a high-fat/high-cholesterol diet to develop the NASH model, with nitrite or captopril (100 mg/L, each) supplementation in drinking water for 8 weeks. The effects of nitrite and captopril were evaluated using immunohistochemical analyses of the liver and heart tissues. Dietary nitrite suppressed liver fibrosis in the rats by reducing oxidative stress, as measured using the protein levels of nicotinamide adenine dinucleotide phosphate oxidase components and inflammatory cell accumulation in the liver. Nitrite lowered the blood pressure in hypertensive NASH rats and suppressed left ventricular chamber enlargement. Similar therapeutic effects were observed in a captopril-treated rat NASH model, suggesting the possibility of a common signaling pathway through which nitrite and captopril improve NASH pathology. In conclusion, dietary nitrite attenuates the development of NASH with cardiovascular involvement in rats and provides an alternative NASH therapeutic strategy.
DOI： 10.3390/ijms23062931
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Lifestyle-mediated nitric oxide boost to prevent SARS-CoV-2 infection: A perspective. 査読あり 国際誌
Jun Kobayashi
Nitric Oxide 115 55 - 61 2021年08月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：ELSEVIER
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide and has seriously threatened public health by causing significant morbidity and mortality. Patients with coronavirus disease (COVID-19) with preexisting endothelial dysfunction caused by aging, diabetes, hypertension, and obesity are at high risk for life-threatening thromboembolic complications. This suggests a possibility that reduced endothelial nitric oxide (NO) production and NO bioavailability could be a common underlying pathology for the progression of COVID-19. Increasingly, evidence from experimental and clinical studies of SARS-CoV-2 infection shows that NO inhibits the pathogenesis of COVID-19, including virus entry into host cells, viral replication, host immune response, and subsequent thromboembolic complications. Restoring NO bioavailability may have the potential to be a preventive or early-treatment option for COVID-19. This review aims to provide in-depth discussion of NO bioavailability to prevent SARS-CoV-2 infection, particularly by focusing on lifestyle factors such as nitrate-rich diets, physical exercise, and nasal breathing, which could be easily performed on a daily basis to boost NO bioavailability.
DOI： doi: 10.1016/j.niox.2021.08.001
その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340570/
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Letter to the editor: Effects of inhaled nitric oxide in COVID‐19‐induced ARDS–Is it worthwhile? 査読あり 国際誌
Jun Kobayashi
Acta Anaesthesiologica Scandinavica 2021年07月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Wiley
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NO不足妊娠高血圧ラットの胎仔発育不全に対する亜硝酸塩補給の影響 査読あり
薗田 邦博、大竹 一男、河野 有華、小林 順
金城学院大論集 自然科学編 17 ( 2 ) 3 - 9 2021年03月
記述言語：日本語 掲載種別：研究論文（大学，研究機関等紀要）
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Nitrite in breast milk: roles in neonatal pathophysiology. 査読あり 国際誌
Jun Kobayashi
Pediatric Research 1 - 7 2020年11月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Nature Publishing Group
Dietary nitrate has beneficial effects on health maintenance and prevention of lifestyle-related diseases in adulthood by serving as an alternative source of nitric oxide (NO) through the enterosalivary nitrate–nitrite–NO pathway, particularly when endogenous NO generation is lacking due to vascular endothelial dysfunction. However, this pathway is not developed in the early postnatal period due to a lack of oral commensal nitrate-reducing bacteria and less saliva production than in adults. To compensate for the decrease in nitrite during this period, colostrum contains the highest amount of nitrite compared with transitional, mature, and even artificial milk, suggesting that colostrum plays an important role in tentatively replenishing nitrite, in addition to involving a nutritional aspect, until the enterosalivary nitrate–nitrite–NO pathway is established. Increasing evidence demonstrates that breast milk rich in nitrite can be effective in the prevention of neonatal infections and gastrointestinal diseases such as infantile hypertrophic pyloric stenosis and necrotizing enterocolitis, suggesting that breastfeeding is advantageous for newborns at risk, given the physiological role of nitrite in the early postnatal period.
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Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome 査読あり 国際誌
Jun Kobayashi and Isamu Murata
Annals of Intensive Care 61 2020年05月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Springer
COVID-19 is an emerging disease of public health concern. While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory distress syndrome in patients with COVID-19. However, inhaled nitric oxide has not yet been formally evaluated. Given the extent of the COVID-19 pandemic, and the large numbers of hospitalized patients requiring respiratory support, clinical use of inhaled nitric oxide may become an alternate rescue therapy before extracorporeal membrane oxygenation for the management of acute respiratory distress syndrome in patients with COVID-19.
DOI： https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00681-9
その他リンク： https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00681-9
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Chewing well during meals may benefit health via the enterosalivary nitrate-nitrite-nitric oxide pathway. 招待あり 査読あり
Jun Kobayashi
Journal of Gastroenterology and Hepatology Research 8 ( 3 ) 1 - 4 2019年06月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Icing treatment in rats with crush syndrome can improve survival through reduction of potassium concentration and mitochondrial function disorder effect. 査読あり 国際誌
Murata I, Inoue S, Kobayashi J, Inoue Y, Kanamoto I.
Experimental and Therapeutic Medicine 2019年
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Molecular regulation of skeletal muscle mass and the contribution of nitric oxide: a review. 査読あり 国際誌
Kobayashi J, Uchida H, Kofuji A, Ito J, Shimizu M, Kim H, Sekiguchi Y, Kushibe S
FASEB BioAdvances 2019年
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Dietary nitrite attenuates elastase-induced pulmonary emphysema in a mouse model. 査読あり 国際誌
Sonoda K, Ohtake K, Tagiri M, Hirata M, Tamada H, Uchida H, Ito Junta, Kobayashi J.
Biological and Pharmaceutical Bulletin 41 ( 12 ) 1818 - 1823 2018年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
Pulmonary emphysema (PE) is a major pathological feature of chronic obstructive pulmonary disease (COPD) and is characterized by proteolytic destruction of the alveolar structure and subsequent inflammation of the respiratory tract. We hypothesized that nitrite attenuates the development of PE via anti-inflammatory actions. PE was induced by intratracheal instillation of porcine pancreas elastase (PPE) in mice. Dietary nitrite dose-dependently (50 and 150 mg/L in drinking water) attenuated emphysematous development and macrophage accumulation in the alveolar parenchyma 21 d after PPE treatment. The present study shows that dietary nitrite might be a possible nutritional strategy in preventing the development of PE in mice.
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Effects of diet and gut environment on the gastrointestinal formation of N-nitroso compounds: a review. 査読あり
Kobayashi J
Nitric Oxide 73 66 - 73 2018年02月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Nitrite as a pharmacological intervention for the successful treatment of crush syndrome 招待あり 査読あり
Jun Kobayashi and Isamu Murata
Physiological Reports 6 ( 5 ) 2018年
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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L-NAME誘発性高血圧ラットの血圧に対する亜硝酸塩とニフェジピンの相互作用 査読あり
薗田邦博、大竹一男、内田博之、玉田葉月、小林順
金城学院大学大学院人間生活学研究科論集 2018年
記述言語：日本語 掲載種別：研究論文（その他学術会議資料等）