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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Laboratory Address |
埼玉県坂戸市けやき台1-1 |
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Laboratory Phone number |
049-271-7503 |
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External Link |
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NAGAI Makie
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Degree 【 display / non-display 】
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Medical Science ( 2012.03 Kanazawa Medical University )
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Nursing Science ( 2006.03 Ishikawa Prefectural Nursing University )
Research Interests 【 display / non-display 】
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Community Mental Health
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CBT-I
External Career 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical 特任教授
2025.04
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筑波大学 高等研究院(TIAR),国際統合睡眠医科学研究機構(WPI-IIIS) 客員研究員
2025.01
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University of Toyama Researcher
2021.06
Papers 【 display / non-display 】
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Reasonable access to brief behavioural insomnia treatment among medical and psychiatric outpatients (RABBIT): a multicentre randomised controlled trial protocol. Invited Reviewed International journal
Makie Nagai, Hiroku Noma, Masatsugu Sakata, Hitomi Oi, Jun Shigematsu, Kenta Matsumura, Toshi A Furukawa, Shun Nakajima
BMJ open 15 ( 5 ) e094602 2025.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
INTRODUCTION: Insomnia is a significant global health issue associated with substantial economic costs. International guidelines recommend cognitive behavioural therapy for insomnia (CBT-I) as the first-line treatment for chronic insomnia; however, pharmacotherapy remains more common in clinical practice. Maintaining the effectiveness while reducing the time and frequency of CBT-I is essential for its implementation. We conducted a randomised controlled trial (RCT) to evaluate the effectiveness of a brief behavioural treatment for insomnia (BBTI) that focuses on sleep restriction and stimulus control (SC)-both established as effective standalone interventions. This article presents the study protocol to examine whether adding BBTI to treatment as usual improves outcomes in patients with chronic insomnia. METHODS AND ANALYSIS: We will conduct a multicentre RCT. We will randomly assign patients with chronic insomnia to two groups (BBTI vs sleep hygiene) in a 1:1 ratio. The BBTI consists of three 15 min sessions over 4 weeks delivered by healthcare professionals following a detailed manual. The primary outcome is the Insomnia Severity Index at 8 weeks. Secondary outcomes include sleep latency, wake after sleep onset, total sleep time, sleep efficiency, Generalized Anxiety Disorder-7, Patient Health Questionnaire-9 and EuroQol-5D-5L. We will conduct the assessment at weeks 0 (baseline), 4 (end of intervention), 8 (post-intervention, primary endpoint) and 12 (follow-up). We will assess each sleep variable from the sleep diary at weeks 0 and 8. The analysis will be performed on an intention-to-treat basis. ETHICS AND DISSEMINATION: This study has been approved by the Ethics Committee for Clinical and Epidemiological Research of Toyama University (approval no. R2023152). TRIAL REGISTRATION NUMBER: UMIN000052911; pre-results.
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Factors related to sedentary behavior of pregnant women during the second/third trimester: prospective results from the large-scale Japan Environment and Children's Study. Reviewed International journal
Makie Nagai, Akiko Tsuchida, Kenta Matsumura, Haruka Kasamatsu, Hidekuni Inadera
BMC public health 24 ( 1 ) 3182 - 3182 2024.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Prolonged sedentary behavior in pregnant women is reported to be associated with worse health-related indices and pregnancy outcomes. The aim of this study was to identify relevant factors that can be targeted in interventions to reduce sedentary behavior during pregnancy. METHODS: Of 103,057 pregnancies registered in the Japan Environment and Children's Study, 83,733 pregnant women were included for analysis after excluding multiple enrollments, nonresponses, and missing outcome data. Data were collected using the International Physical Activity Questionnaire and analyzed using logistic regression models to calculate crude and adjusted odds ratios. Missing data were handled using multiple imputations, and statistical analyses were performed using SAS software. RESULTS: Mean sedentary behavior time increased from 5.4 h/day before pregnancy to 5.9 h/day during pregnancy. The percentage of women classified in the high sedentary behavior group increased from 25.6% before pregnancy to 31.2% during pregnancy. Factors associated with high sedentary behavior during pregnancy included longer hours spent watching television and playing video games before pregnancy, higher annual household income, and working status during pregnancy. Possible protective factors against high sedentary behavior included engaging in ≥ 150 min of moderate to vigorous physical activity per week before pregnancy. CONCLUSIONS: This large-scale cohort study provides valuable insights into sedentary behavior patterns among pregnant women in Japan. To reduce the amount of time engaged in sedentary behavior during pregnancy, the planning and management of time spent watching TV and playing video games as well as establishing exercise habits before pregnancy are recommended.
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Evaluation of a Japanese brief CBT-I administered by a nurse: a pilot study. Reviewed International journal
Makie Nagai, Yuki Oe, Masaru Horikoshi, Shun Nakajima, Hitomi Oi, Yoshikuni Kita
Primary health care research & development 23 e42 2022.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
AIM: The aim of this pilot study is to evaluate a Japanese version of brief Cognitive Behavioral Therapy for Insomnia (CBT-I) and contribute to primary care which leads to prevention of a lifestyle-related disease or a psychiatric disorder. METHOD: A single-arm study in nine patients with chronic insomnia who were under the pharmacotherapy was executed. The Insomnia Severity Index (ISI), the Athens Insomnia Scale (AIS), and the European Quality of Life 5 Items (EQ-5D) were assessed at the beginning of intervention, at the end of intervention, and after 12 weeks. FINDINGS: There were no patient dropouts nor adverse events. The average change in ISI score was -7.33 (95% CI: -10.31 to -4.36) at post-treatment and -6.11 (95% CI: -8.20 to -4.03) at the 12-week follow-up point (Cohen's d = 2.25). The AIS score improved as well, and the EQ-5D score improved after 12 weeks. The safety and efficacy of the brief CBT-I were suggested.
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An assessment of stress coping for mental health promotion among Information Technology employees in Japan Reviewed
Makie Nagai, Yuko Morikawa, Yuko Hamazaki, Hideaki Nakagawa
Archives of Depression and Anxiety 2019.05
Authorship：Lead author Language：English
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Worries of independent older people regarding health and daily life: a survey of residents of a rural town in Japan. Reviewed International journal
Yuko Hamazaki, Makie Nagai
Journal of community health nursing 29 ( 4 ) 225 - 35 2012
Language：English
The purpose of the study was to analyze the worries of independent older people regarding health and daily life. We collected data from 259 people who responded to the free descriptive questionnaire and analyzed it qualitatively and inductively. Thirteen categories derived from the results were classified into 6 types of worries: health worries, life function worries, daily life worries, long-term care worries, family relationship worries, and future life worries. Promoting the prevention of "long-term care status," the need for physical nursing care, in a super aging society, where the population of 65 years or older is more than 21% of all of the population, requires consideration of not only measures to deal with physical symptoms, but also measures to deal with psychological aspects, and social aspects.
Books and Other Publications 【 display / non-display 】
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Strengths-Based Nurising Care ;HEALTH AND HEALING FOR PERSON AND FAMILY
（ Role： Joint translator）
2020.07
Misc 【 display / non-display 】
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不眠を対象とした看護師による短時間認知行動療法の評価 パイロットスタディ
長井 麻希江, 大江 悠樹, 堀越 勝, 中村 主計, 喜多 義邦
日本認知療法・認知行動療法学会プログラム・抄録集 19回 242 - 242 2019.08
Language：Japanese Publisher：日本認知療法・認知行動療法学会
Presentations 【 display / non-display 】
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超簡易型認知行動療法を活用した中小企業における一次予防の効果－自由記載内容の質的分析－
石橋佐枝子, 長井麻希江, 秋山剛
第19回日本認知療法・認知行動療法学会 2019.08
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不眠を対象とした看護師による短時間認知行動療法の評価（パイロットスタディ）
長井麻希江, 大江悠樹, 堀越勝, 中村主計, 喜多義邦
第19回日本認知療法・認知行動療法学会 2019.08
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短時間認知行動療法に基づく外来看護面接が不眠・抑うつの改善をもたらした一事例
長井 麻希江
第29回日本精神保健看護学会学術集会 2019.06
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抑うつ症状気の低減と復職が実現したうつ病患者に対するCBT内容の検討
長井 麻希江, 玉井 顕
第18回日本認知療法・認知行動療法学会 2018.10
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アンガ－マネジメント学習による看護管理職者のストレス対処行動の変化
下門 すみえ, 長井 麻希江, 森北裕美子他
第22回日本看護管理学会 2018.08
Scientific Research Funds Acquisition Results 【 display / non-display 】
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不眠の超短時間型認知行動療法の効果解明と社会実装に向けた研究
Grant number：23K27815 2024.04 - 2026.03
日本学術振興会 日本学術振興会科学研究費補助金基盤（B) 基盤研究(B)
Authorship：Principal investigator Grant type：Competitive
Grant amount：\14040000 （ Direct Cost: \10800000 、 Indirect Cost：\3240000 ）
1．超短時間型CBT-Iの開発（2023年10月迄）：先行研究で開発した短時間で実施可能な不眠に対する認知行動療法（Cognitive Behavioral Therapy for Insomnia；CBT-I）を、面接回数を減らしてさらに所要時間を短縮するよう改良した。併せて睡眠アセスメントシート・教育用シート、睡眠記録シートも改良、刷新した。その上で、セラピスト向けの実践マニュアルを作成した。
2．セラピストのトレーニング（同年12月迄）：全国4か所の病院・クリニックに所属するセラピスト（コメディカルスタッフ）を対象に、定期的な実践トレーニングを遠隔で実施した。共同研究者らが医療コミュニケーションの基本、CBTの基本、本研究で開発した超短時間型CBT-Iの研修を行った後、対面でのワークショップを開いて実践的な演習を行った。
3．研究倫理審査ならびに研究協力施設の実施許可申請（同年12月迄）：富山大学臨床・疫学研究等に関する倫理審査委員会に倫理審査を申請し、承認を得た（R2023152)。その後、研究協力施設より、実施許可を得た。
4．臨床試験登録（2024年1月）：本研究について、開発した超短時間型CBT-Iの有効性を検証する多施設共同無作為化並行群間比較試験として臨床試験登録を行った（UMIN000052911）。
5．臨床登録・介入・スーパーバイズ開始（2024年1月末～）：研究協力施設との連絡・調整、インフォームドコンセントの準備、臨床登録・データ入力のシステム配備などを経て、臨床登録を開始した。登録者数はまだ少ないが、介入群に実施される超短時間型CBT-Iの録音データをもとに、各セラピストを担当する共同研究者が継続的にスーパーバイズを実施している。 -
不眠の超短時間型認知行動療法の効果解明と社会実装に向けた研究
Grant number：23H03125 2023.04 - 2024.03
日本学術振興会科学研究費補助金基盤(B) 基盤研究(B)
長井 麻希江
Authorship：Principal investigator
Grant amount：\14040000 （ Direct Cost: \10800000 、 Indirect Cost：\3240000 ）
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不眠を対象とした外来看護師による10分間CBTの評価
Grant number：JP18K10315 2018.04 - 2022.03
文部科学省 日本学術振興会科学研究費補助金(C) 基盤（C)
Authorship：Principal investigator Grant type：Competitive
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職業性ストレス低減のための看護ケアプログラムの開発とその評価
Grant number：21592929 2009.04 - 2011.03
日本学術振興会科学研究費補助金基盤（C）
Authorship：Principal investigator Grant type：Competitive