論文 - 阿久津　裕士

Asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a thiourea organocatalyst 査読あり

Taro Koda, Hiroshi Akutsu, Mitsuaki Suzuki, Kosuke Nakashima, Shin-ichi Hirashima, Akihiro Yoshida, Tsuyoshi Miura, Takashi Yamanoi

Tetrahedron Letters   155   155392 - 155392   2025年01月

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担当区分：責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.tetlet.2024.155392

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Regioselective One-Pot Synthesis of Vicinal Bisphosphine Derivatives from Nitroalkenes by Hydrophosphinylation/Elimination/Hydrophosphinylation. 査読あり 国際誌

Eiki Hirota, Shin-Ichi Hirashima, Ryuki Morita, Junya Takase, Yasuyuki Matsushima, Kosuke Nakashima, Hiroshi Akutsu, Tsuyoshi Miura

Organic letters   26 ( 9 )   1797 - 1802   2024年03月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Herein, a facile method is developed for the synthesis of vicinal bisphosphine derivatives based on a cascade of hydrophosphinylation, elimination, and hydrophosphinylation of secondary phosphine oxides with nitroalkenes. This cascade reaction provides step-economy access to a series of vicinal bisphosphine derivatives with high to excellent yields (up to 99%). This method was further extended to prepare, in one-pot, regioselective vicinal bisphosphine derivatives that incorporated two different phosphorus functional groups.

DOI： 10.1021/acs.orglett.3c04297

PubMed

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Asymmetric Direct Vinylogous Conjugate Addition of α,β‐Unsaturated γ‐Butyrolactam to Acyl Acrylonitriles using Organocatalysts 査読あり

Daiki Ishii, Shin-ichi Hirashima, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Hiroshi Akutsu, Tsuyoshi Miura

Asian Journal of Organic Chemistry   2023年02月

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

DOI： 10.1002/ajoc.202300082

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Asymmetric Direct Vinylogous Conjugate Addition of Substituted Furanone Derivatives to ( E )‐ and ( Z) ‐Benzoyl Acrylonitriles Using Organocatalysts 査読あり

Daiki Ishii, Shin‐ichi Hirashima, Hiroshi Akutsu, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Tsuyoshi Miura

Asian Journal of Organic Chemistry   11 ( 5 )   2022年03月

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

Abstract

Diaminomethylenemalononitrile organocatalysts efficiently promoted the asymmetric direct vinylogous conjugate addition of α‐angelica lactone to (E)‐ and (Z)‐benzoyl acrylonitrile derivatives. The synthesized products bear vicinal tertiary and quaternary stereogenic centers with excellent enantioselectivities (up to 98% ee). This report is the first successful example of the stereoselective conjugate addition using (Z)‐benzoyl acrylonitriles as Michael acceptor.

DOI： 10.1002/ajoc.202200048

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajoc.202200048

Diaminomethylenemalononitrile as a Chiral Single Hydrogen Bond Catalyst: Application to Enantioselective Conjugate Addition of α‐Branched Aldehydes 査読あり

Masahiro Kawada, Ryo Tsuyusaki, Kosuke Nakashima, Hiroshi Akutsu, Shin‐ichi Hirashima, Takashi Matsumoto, Hikaru Yanai, Tsuyoshi Miura

Chemistry – An Asian Journal   16 ( 16 )   2272 - 2275   2021年08月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

DOI： 10.1002/asia.202100487

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/asia.202100487

Asymmetric Direct Vinylogous Conjugate Addition of Substituted Furanone Derivatives to Benzoyl Acrylonitrile: Stereoselective Synthesis Toward Bicyclic γ-Lactams 査読あり

Daiki Ishii, Shin-ichi Hirashima, Kosuke Nakashima, Hiroshi Akutsu, Takaaki Sakai, Yasuyuki Matsushima, Masahiro Kawada, Tsuyoshi Miura

Organic Letters   23 ( 2 )   480 - 485   2021年01月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Chemical Society (ACS)  

DOI： 10.1021/acs.orglett.0c04004

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Asymmetric Conjugate Addition of α-Cyanoketones to Benzoyl Acrylonitrile Derivatives Using a Diaminomethylenemalononitrile Organocatalyst 査読あり

Hiroshi Akutsu, Kosuke Nakashima, Yuta Kanetsuna, Masahiro Kawada, Shin-ichi Hirashima, Tsuyoshi Miura

Synthesis   52 ( 24 )   3874 - 3880   2020年09月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Georg Thieme Verlag KG  

DOI： 10.1055/s-0040-1707285

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Organocatalytic asymmetric conjugate addition of substituted 5-benzylfurfurals to nitroalkenes based on stereocontrol of trienamine 査読あり

Hiroshi Akutsu, Mifuyu Ito, Masahiro Kawada, Kosuke Nakashima, Shin-ichi Hirashima, Tsuyoshi Miura

Tetrahedron Letters   61 ( 6 )   151478 - 151478   2020年02月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.tetlet.2019.151478

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Asymmetric Conjugate Addition of Phosphonates to Enones Using Cinchona–Diaminomethylenemalononitrile Organocatalysts 査読あり

Ryoga Arai, Shin-ichi Hirashima, Tatsuki Nakano, Masahiro Kawada, Hiroshi Akutsu, Kosuke Nakashima, Tsuyoshi Miura

The Journal of Organic Chemistry   85 ( 5 )   3872 - 3878   2020年01月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Chemical Society (ACS)  

DOI： 10.1021/acs.joc.9b02553

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Highly efficient asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a thiourea organocatalyst 査読あり

Hiroshi Akutsu, Kosuke Nakashima, Shin-ichi Hirashima, Hikari Matsumoto, Yuji Koseki, Tsuyoshi Miura

Tetrahedron   75 ( 76 )   2431 - 2435   2019年04月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.tet.2019.03.013

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Asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a diaminomethylenemalononitrile organocatalyst

Hiroshi Akutsu, Kosuke Nakashima, Shin-ichi Hirashima, Moeko Kitahara, Yuji Koseki, Tsuyoshi Miura

Tetrahedron Letters   58 ( 51 )   4759 - 4762   2017年12月

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.tetlet.2017.10.078

Web of Science

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Design of Novel Hydrogen-Bonding Donor Organocatalysts and Their Application to Asymmetric Direct Aldol Reaction 査読あり

Hiroshi Akutsu, Kosuke Nakashima, Hikaru Yanai, Akira Kotani, Shin-ichi Hirashima, Tomoyuki Yamamoto, Ryuta Takahashi, Akihiro Yoshida, Yuji Koseki, Hideki Hakamata, Takashi Matsumoto, Tsuyoshi Miura

Synlett   28 ( 11 )   1363 - 1367   2017年07月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Georg Thieme Verlag KG  

DOI： 10.1055/s-0036-1558971

Web of Science

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Pyrrolidine–diaminomethylenemalononitrile organocatalyst for solvent-free asymmetric direct aldol reactions 査読あり

Kosuke Nakashima, Shin-ichi Hirashima, Hiroshi Akutsu, Yuji Koseki, Norihiro Tada, Akichika Itoh, Tsuyoshi Miura

Tetrahedron Letters   56 ( 3 )   558 - 561   2015年01月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.tetlet.2014.11.117

Web of Science

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