Papers - Hazama Yutaro
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Hideo Ueda, Yutaro Hazama and Akira Yoshida
Japanese Journal of Pharmaceutical Education 9 2025.12
Authorship：Second author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society for Pharmaceutical Education
In the revised 2022 edition of the Model Core Curriculum for Pharmaceutical Education, “professionalism” is identified as the foremost fundamental quality and competency required of pharmacists. The curriculum underscores the importance of maintaining a continuous and reflective attitude toward the question, “What is professionalism?” While establishing a uniform definition of professionalism remains challenging, it is generally grounded in the idea that pharmacists should demonstrate their specialized knowledge and skills while prioritizing patients’ best interests, based on non-cognitive abilities such as ethical awareness and communication skills that enable
understanding of the patient’s context. Since personal growth and awareness of interpersonal relationships are often cultivated through direct experiences, practice, and reflection, it is essential to intentionally provide educational opportunities that facilitate such development. This paper explores the cultivation of professionalism through interprofessional education and project-based learning, focusing on the key
concepts of “collaboration” and “cooperation.”Other Link： https://www.jstage.jst.go.jp/article/jjphe/9/0/9_e09039/_pdf/-char/ja
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Sekijima, Hidehisa ; Hazama, Yutaro ; Kimura, Soichiro ; Morimoto, Yasunori ; Ueda, Hideo
Journal of drug delivery and therapeutics 14 ( 3 ) 27 - 38 2024.03
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Satoko Enjo, Yutaro Hazama, Soichiro Kimura, Yasunori Morimoto, Hideo Ueda
Journal of Advanced Pharmaceutical Technology & Research 14 ( 2 ) 94 - 98 2023.04
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4103/japtr.japtr_647_22
Other Link： http://dx.doi.org/10.4103/japtr.japtr_647_22
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Direct nose-to-brain delivery of diazepam via trigeminal nerve contributes to rapid seizure suppression in pentylenetetrazole-induced status epilepticus model rats Reviewed International journal
Kazutoshi Watanabe, Soichiro Kimura, Yutaro Hazama, Yasunori Morimoto, Hideo Ueda
Journal of Drug Delivery and Therapeutics 13 ( 1 ) 44 - 56 2023.01
Language：English Publishing type：Research paper (scientific journal) Publisher：Society of Pharmaceutical Technocrats
The purpose of our present study was to elucidate the involvement of the direct transfer to the brain after intranasal (i.n.) administration of diazepam (DZP), and to provide findings whether i.n. the administration could be used to obtain rapid onset of pharmacological action. We determined the blood and brain kinetics of DZP after administrations of i.n. and other routes, and the relationship between their concentrations and rapid seizure suppression effect; furthermore, and evaluated the distribution process of DZP to the brain. There was a negative connection between the plasma concentration and the amount of DZP delivery to the brain from the systemic circulation during the period that followed intravenous and intrarectal injection before the onset of seizure suppression. I.n. administration resulted in the seizure suppression time below the correlation curve: the seizure suppression effects were observed earlier than estimated despite the low plasma concentrations of DZP, suggesting the involvement of direct nose-to-brain delivery of DZP. The time to maximum concentration (Tmax) in the forebrain, hindbrain, olfactory bulb (OB), trigeminal nerve (TN), and cerebrospinal fluid (CSF) after i.n. the administration was 3 min, which was shorter than the Tmax of the plasma concentration. In fluorescence imaging using Rhodamin-B-base, the TN and the area of the vicinity of the thalamus had stronger fluorescence 1 and 3 min after i.n. administration, compared with the OB and CSF. In summary, direct brain delivery of DZP requires the TN and it was suggested that distribution to the vicinity of the thalamus via the TN may be connected to the quick seizure suppression effect.
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Data on the activity of place cells in the hippocampal CA1 subfield of a monkey performing a shuttling task Reviewed International journal
間 祐太朗, 田村 了以
Data in Brief 26 1044672 2019.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier
This data article provides spike-timestamps of place cells recorded in a male Japanese monkey and the animal's sequential positions during the performance of a shuttling task on a rectangular track. All data were recorded in the right hippocampal CA1 subfield, while the monkey performed the task under a freely behaving condition. These were the source data on the monkey place cells in our related research article entitled "Effects of self-locomotion on the activity of place cells in the hippocampus of a freely behaving monkey" [1]. In addition, here we show a movement directional activity of a place cell in two-dimensional space as an example of data utilization. The source data are freely accessible [2] and can be used by other researchers to obtain new insights into place cells, such as functional differences between animal species.
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Effects of self-locomotion on the activity of place cells in the hippocampus of a freely behaving monkey. Reviewed International journal
Yutaro Hazama, Ryoi Tamura
Neuroscience Letters 701 32 - 37 2019.05
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier
The activity of hippocampal cell assemblies is considered to function as the neural substrate for a cognitive map in various animal species. The firing rate of hippocampal place cells increases when an individual animal reaches a specific location in an environment. Although cumulative views on place cells have been revealed by studies using rodents under free-behavior conditions, few studies have addressed the spatial representation provided by hippocampal neurons in primates. Moreover, although previous work in rats has demonstrated the importance of locomotion velocity and direction in the spatially selective discharge of hippocampal neurons, it remains unknown whether a corresponding phenomenon exists in the primate hippocampus. In the present study, we recorded the activity and investigated the spatial representation of the hippocampal neurons in a freely behaving monkey performing a shuttle-movement task. We observed increased activity in a subset of hippocampal neurons (place cells) when the monkey crossed a particular location. Many of the monkey place cells exhibited sensitivity to locomotion velocity rather than to locomotion direction. These results suggest the existence of primate hippocampal place cells comparable to those in rodents, with the exception that, in primates, velocity information has a stronger impact on place cell activity than directional information.
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Preclinical study of tacrolimus ointment for prevention of its systemic absorption in atopic dermatitis model mice according to their skin conditions Reviewed
Yutaro Hazama, Wataru Uchida, Toshihisa Maekawa,Ryotaro Miki, Shinji Oshima, Yuya Egawa, Osamu Hosoya, Toshinobu Seki
Japanese Journal of Pharmaceutical Health Care and Sciences 43 ( 9 ) 477 - 491 2017.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Pharmaceutical Health Care and Sciences
Tacrolimus (TL) is used topically for atopic dermatitis (AD) treatment. In AD, the skin shows various physiological alterations across individuals, body sites, and time-courses. Our previous study using rats showed that alterations in the skin barrier function and skin blood flow affected systemic absorption of topically applied TL. In this study, we performed an in vivo skin absorption study using NC/Nga mice repeatedly administered Dermatophagoides farinae extract as an AD animal model to assess skin barrier function and skin blood flow. We used three types of TL ointment: or iginal TL ointment (Protopic® 0.1％ ointment) and liquid paraffin-diluted TL ointment with or without adrenaline (0.5w /w％) to suppress systemic absorption of TL. Skin barrier function correlated positively with the systemic absorption of TL in AD skin as well as in tape-stripped rat skin, and dilution of TL ointment suppressed TL absorption and showed high skin TL retention. Although skin blood flow affected TL absorption as the skin barrier was disrupted, the distinct relationship among skin blood flow, TL absorption, and the effect of combined-use of adrenaline was unclear. The relationship between blood and skin disposition of TL was biphasic—the ratio of blood to skin disposition increased rapidly at an inflection point. These results demonstrate that the dilution of TL ointment is useful for increasing treatment safety while retaining efficacy. The observed relationship between TL behavior and skin barrier function in AD model mice may also occur in AD patients and needs to be confirmed in further studies.
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-jjphcs.43.477
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タクロリムス軟膏の安全な使用を志向した皮膚状態が異なる部位に適用した場合の全身および皮膚局所移行動態の解析
間 祐太朗
2016.03
Language：Japanese Publishing type：Doctoral thesis
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-PhDK68
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Effect of physiological changes in the skin on systemic absorption of tacrolimus following topical application in rats Reviewed International journal
Yutaro Hazama, Toshihisa Maekawa, Ryotaro Miki, Shinji Oshima, Yuya Egawa, Kazuhiro Morimoto, Toshinobu Seki
Biological and Pharmaceutical Bulletin 39 ( 3 ) 343 - 352 2016.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
Tacrolimus (TL) ointment is a topical treatment for atopic dermatitis, a disease that exhibits various skin conditions. The effect of skin pathologies on the systemic absorption of TL and related side effects remains unknown. This study aimed to investigate factors affecting the cutaneous absorption of TL. We prepared various skin models in hairless rats by tape stripping, injection of prophlogistic material solution (PMS), and continuous subcutaneous adrenaline (Adr) infusion. In vivo absorption studies were conducted, with measurements of transepidermal water loss (TEWL) and skin blood flow as physiological parameters. Very little TL absorption was observed through intact skin. Greater TL absorption was noted in skins with high TEWL values and fully stripped skin with PMS injections. In contrast, Adr infusion, which reduced skin blood flow, resulted in decreased TL absorption through fully stripped skin. Combined use of TL and Adr on skin with PMS injections resulted in suppression of TL absorption. Our results revealed that TL absorption following topical application is affected by alterations in the skin barrier, blood flow, and vascular permeability. We propose an administration plan for TL in a flowchart as a means of preventing systemic side effects.
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b15-00727
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Investigation of fentanyl patch to evaluate its usability and adhesiveness Reviewed
Shinji Oshima, Yutaro Hazama, Osamu Hosoya, Kengo Nagashima, Toru Tanaka, Sano Motohiko, Soichiro Ohta, Nobuhiro Yasuno, Kazuhiko Juni
Japanese journal of pharmaceutical palliative care and sciences 5 ( 1 ) 7 - 13 2012.03
Authorship：Second author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Pharmaceutical Palliative Care and Sciences
The fentanyl patch, in consideration of its pharmaceutical characteristics, is highly appropriate for the control of background pain in patients with difficulties in oral intake, and in the field of palliative home care. Peeling of the patch or itching during its application period may cause a decrease in its pain-relieving effect and discomfort at the attached site. However, the usability of this kind of patch has been infrequently reported. We investigated three types of fentanyl patch to evaluate their usability and adhesiveness. FentosR tape has been suggested to cause skin irritation after removal because of its high-level adhesiveness. On the other hand, DurotepR MT and OneDuroR patches may show partial peeling or detachment, for which their low-level adhesiveness was considered to be responsible. As there has been a tendency towards long-term treatment in palliative care since the enforcement of the Cancer Control Act, the results of this investigation are considered to provide important information to improve patient adherence, and maintain appropriate pharmacologic therapy.
Other Link： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-18829783_5_7