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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Assistant Professor |
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Laboratory Address |
埼玉県坂戸市けやき台１−１ |
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Contact information |
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External Link |
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Hazama Yutaro
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Degree 【 display / non-display 】
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Doctor (Pharmacy) ( 2016.03 Josai University )
From School 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Science School of Pharmacy (6 year program) Graduated
2006.04 - 2012.03
Country：Japan
From Graduate School 【 display / non-display 】
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Josai University Graduate School, Division of Pharmaceutical Sciences Pharmacy (Doctoral Program, 4 years) Doctor's Course Completed
2012.04 - 2016.03
Country：Japan
Studying abroad experiences 【 display / non-display 】
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2014.09 - 2015.02 UCL School of Pharmacy Research student
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Assistant Professor
2019.04
External Career 【 display / non-display 】
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University of Toyama Researcher
2016.04 - 2019.03
Country：Japan
Professional Memberships 【 display / non-display 】
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日本神経科学学会
2021.03
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The Pharmaceutical Society of Japan
2011.04
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The Academy of Pharmaceutical Science and Technology, Japan
2013.04 - 2023.05
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Society for Neuroscience
2017.11 - 2019.03
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Japan Society for Pharmaceutical Education
2017.04 - 2021.03
Research Career 【 display / non-display 】
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Investigation of Sleep Disorder Therapy via Sleep–Wake Regulation by Low-Intensity Pulsed Ultrasound Stimulation
Project Year： 2022.04 -
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EEG Assessment of Seizure Suppression by Intranasal Diazepam
Project Year： 2024.04 -
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Study on the Reversible Modulation of Drug–Protein Binding Affinity via Low-Intensity Ultrasonic Stimulation
Project Year： 2020.04 - 2023.03
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Encoding mechanism of spatial information in the primate hippocampus.
Grant-in-Aid for Scientific Research
Project Year： 2016.04 - 2019.03
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Investigation of the effect of residual phase volume on the permeation of ibuprofen through human skin
Cooperative Research
Project Year： 2014.09 - 2015.02
Papers 【 display / non-display 】
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Sekijima, Hidehisa ; Hazama, Yutaro ; Kimura, Soichiro ; Morimoto, Yasunori ; Ueda, Hideo
Journal of drug delivery and therapeutics 14 ( 3 ) 27 - 38 2024.03
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Satoko Enjo, Yutaro Hazama, Soichiro Kimura, Yasunori Morimoto, Hideo Ueda
Journal of Advanced Pharmaceutical Technology & Research 14 ( 2 ) 94 - 98 2023.04
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4103/japtr.japtr_647_22
Other Link： http://dx.doi.org/10.4103/japtr.japtr_647_22
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Direct nose-to-brain delivery of diazepam via trigeminal nerve contributes to rapid seizure suppression in pentylenetetrazole-induced status epilepticus model rats Reviewed International journal
Kazutoshi Watanabe, Soichiro Kimura, Yutaro Hazama, Yasunori Morimoto, Hideo Ueda
Journal of Drug Delivery and Therapeutics 13 ( 1 ) 44 - 56 2023.01
Language：English Publishing type：Research paper (scientific journal) Publisher：Society of Pharmaceutical Technocrats
The purpose of our present study was to elucidate the involvement of the direct transfer to the brain after intranasal (i.n.) administration of diazepam (DZP), and to provide findings whether i.n. the administration could be used to obtain rapid onset of pharmacological action. We determined the blood and brain kinetics of DZP after administrations of i.n. and other routes, and the relationship between their concentrations and rapid seizure suppression effect; furthermore, and evaluated the distribution process of DZP to the brain. There was a negative connection between the plasma concentration and the amount of DZP delivery to the brain from the systemic circulation during the period that followed intravenous and intrarectal injection before the onset of seizure suppression. I.n. administration resulted in the seizure suppression time below the correlation curve: the seizure suppression effects were observed earlier than estimated despite the low plasma concentrations of DZP, suggesting the involvement of direct nose-to-brain delivery of DZP. The time to maximum concentration (Tmax) in the forebrain, hindbrain, olfactory bulb (OB), trigeminal nerve (TN), and cerebrospinal fluid (CSF) after i.n. the administration was 3 min, which was shorter than the Tmax of the plasma concentration. In fluorescence imaging using Rhodamin-B-base, the TN and the area of the vicinity of the thalamus had stronger fluorescence 1 and 3 min after i.n. administration, compared with the OB and CSF. In summary, direct brain delivery of DZP requires the TN and it was suggested that distribution to the vicinity of the thalamus via the TN may be connected to the quick seizure suppression effect.
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Data on the activity of place cells in the hippocampal CA1 subfield of a monkey performing a shuttling task Reviewed International journal
間 祐太朗, 田村 了以
Data in Brief 26 1044672 2019.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier
This data article provides spike-timestamps of place cells recorded in a male Japanese monkey and the animal's sequential positions during the performance of a shuttling task on a rectangular track. All data were recorded in the right hippocampal CA1 subfield, while the monkey performed the task under a freely behaving condition. These were the source data on the monkey place cells in our related research article entitled "Effects of self-locomotion on the activity of place cells in the hippocampus of a freely behaving monkey" [1]. In addition, here we show a movement directional activity of a place cell in two-dimensional space as an example of data utilization. The source data are freely accessible [2] and can be used by other researchers to obtain new insights into place cells, such as functional differences between animal species.
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Effects of self-locomotion on the activity of place cells in the hippocampus of a freely behaving monkey. Reviewed International journal
Yutaro Hazama, Ryoi Tamura
Neuroscience Letters 701 32 - 37 2019.05
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier
The activity of hippocampal cell assemblies is considered to function as the neural substrate for a cognitive map in various animal species. The firing rate of hippocampal place cells increases when an individual animal reaches a specific location in an environment. Although cumulative views on place cells have been revealed by studies using rodents under free-behavior conditions, few studies have addressed the spatial representation provided by hippocampal neurons in primates. Moreover, although previous work in rats has demonstrated the importance of locomotion velocity and direction in the spatially selective discharge of hippocampal neurons, it remains unknown whether a corresponding phenomenon exists in the primate hippocampus. In the present study, we recorded the activity and investigated the spatial representation of the hippocampal neurons in a freely behaving monkey performing a shuttle-movement task. We observed increased activity in a subset of hippocampal neurons (place cells) when the monkey crossed a particular location. Many of the monkey place cells exhibited sensitivity to locomotion velocity rather than to locomotion direction. These results suggest the existence of primate hippocampal place cells comparable to those in rodents, with the exception that, in primates, velocity information has a stronger impact on place cell activity than directional information.
Presentations 【 display / non-display 】
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Effects of Transcranial Ultrasound Stimulation to the Primary Motor Cortex on Wheel-Running Activity in a Sleep Disorder Model Mouse
2024.11 Japanese Society for Chronobiology
Event date： 2024.11
Language：Japanese Presentation type：Poster presentation
Country：Japan
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DZP溶液を鼻腔内にsprayおよびdrop投与したときの脳移行特性の比較検討
渡邊 一理, 間 祐太朗, 木村 聡一郎, 上田 秀雄
日本薬学会第143年会（札幌）
Event date： 2023.03
Language：Japanese Presentation type：Oral presentation (general)
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表皮ランゲルハンス細胞による抗原獲得に対する超音波適用の影響
遠城 聡子, 伊東 将輝, 間 祐太朗, 木村 聡一郎, 上田 秀雄
日本薬学会第143年会（札幌）
Event date： 2023.03
Language：Japanese Presentation type：Oral presentation (general)
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低強度超音波刺激によるジアゼパムのタンパク結合能の可逆的変調に関する検討
間 祐太朗､ 鳥羽 俊邦, 渡邊 一理, 遠城 聡子, 木村 聡一郎, 上田 秀雄
日本薬学会第143年会（札幌）
Event date： 2023.03
Language：Japanese Presentation type：Poster presentation
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ジアゼパム溶液の鼻腔内投与液量を変化させたときの粘膜吸収面積と全身吸収性および痙攣抑制効果の関係に関する検討
渡邊一理, 遠藤美波, 間祐太朗, 木村聡一郎, 森本雍憲, 上田秀雄
日本薬学会第142年会（名古屋）
Event date： 2022.03
Language：Japanese
Scientific Research Funds Acquisition Results 【 display / non-display 】
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低強度パルス超音波刺激によるミクログリア機能調節を介した睡眠障害治療の検討
2022.04 - 2025.03
科学研究費補助金 若手研究
間祐太朗
Social Activities 【 display / non-display 】
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模擬授業「ばけ学を通して患者を守る 考えよう！このおくすり、溶けるの？溶けないの？」埼玉県立大宮南高等学校
Role(s)： Lecturer
埼玉県立大宮南高等学校 2024.10
Type：Visiting lecture
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模擬授業「AI vs 薬剤師〜人らしい仕事ってなに？〜」叡明高等学校
Role(s)： Lecturer
叡明高等学校 2023.12
Type：Visiting lecture
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模擬授業「AI vs 薬剤師〜人らしい仕事ってなに？〜」西武台高等学校
Role(s)： Lecturer
西武台高等学校 2023.11
Type：Visiting lecture
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模擬授業「AI vs 薬剤師〜人らしい仕事ってなに？〜」埼玉県立久喜北陽高等学校
Role(s)： Lecturer
埼玉県立久喜北陽高等学校 2022.10
Type：Visiting lecture
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模擬授業「AI vs 薬剤師〜人らしい仕事ってなに？〜」埼玉県立南稜高等学校
Role(s)： Lecturer
埼玉県立南稜高等学校 埼玉県立南稜高等学校 2020.11
Audience： High school students
Type：Visiting lecture