論文 - 井上 直子
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介護支援専門員調査より得られた薬剤師が優先的に取り組む要介護者の抱える薬の問題 査読あり
堀井徳光,井上直子, 大嶋繁, 冲田光良,秋元勇人, 根岸彰生, 大島新司, 沼尻幸彦, 小林大介
日本老年薬学会雑誌 1 ( 2 ) 28 - 33 2018年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本老年薬学会
地域包括ケアシステムでは、薬剤師は患者の抱える薬の問題解決に中心的な役割を果たすことが望まれる。そのためには、要介護者における薬の問題点および解決に関わっている職種を把握し、優先的に解決すべき問題を明確にする必要がある。そこで、城西大学薬局近隣地区に勤務する介護支援専門員を対象として、薬の問題認識および問題解決依頼先を調査した。多くの介護支援専門員は「利用者の薬が余っている」、「利用者の認知力が低下している」を薬の問題として認識していた。また、多くの介護支援専門員が「利用者の薬が余っている」、「利用者が用法・用量を理解していない」を薬剤師に解決を期待していた。地域包括ケアシステムの一翼を担うために薬剤師が優先的に介入すべき薬の問題は、「利用者の薬が余っている」、「利用者の薬の仕分けが必要」、「利用者が服用意義を理解していない」、「利用者が用法・用量を理解していない」と思われた。
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Study on the increased probability of detecting adverse drug reactions based on Bayes' theorem: evaluation of the usefulness of information on the onset timing of adverse drug reactions 査読あり
2. S. Oshima, T. Enjuji, A. Negishi, H. Akimoto, K. Ohara, M. Okita, S. Numajiri, N. Inoue, S. Ohshima, A. Terao
Biological and Pharmaceutical Bulletin 40 ( 9 ) 1389 - 1398 2017年09月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本薬学会
In order to avoid adverse drug reactions (ADRs), pharmacists are reconstructing ADR-related information based on various types of data gathered from patients, and then providing this information to patients. Among the data provided to patients is the time-to-onset of ADRs after starting the medication (i.e., ADR onset timing information). However, a quantitative evaluation of the effect of onset timing information offered by pharmacists on the probability of ADRs occurring in patients receiving this information has not been reported to date. In this study, we extracted 40 ADR–drug combinations from the data in the Japanese Adverse Drug Event Report database. By applying Bayes’ theorem to these combinations, we quantitatively evaluated the usefulness of onset timing information as an ADR detection predictor. As a result, when information on days after taking medication was added, 54 ADR–drug combinations showed a likelihood ratio (LR) in excess of 2. In particular, when considering the ADR–drug combination of anaphylactic shock with levofloxacin or loxoprofen, the number of days elapsed between start of medication and the onset of the ADR was 0, which corresponded to increased likelihood ratios (LRs) of 138.7301 or 58.4516, respectively. When information from 1–7 d after starting medication was added to the combination of liver disorder and acetaminophen, the LR was 11.1775. The results of this study indicate the clinical usefulness of offering information on ADR onset timing.
その他リンク： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b17-00165
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高齢者の安全な薬物治療ガイドラインを用いたdeprescribingの実践と患者のQOLおよびADLの変化 査読あり
大嶋繁、原彩伽、阿部卓巳、秋元勇人、大原厚祐、根岸彰生、沖田光良、大島新司、井上直子、沼尻幸彦、小川越史、齋木実、小林大介
YAKUGAKU ZASSHI 137 ( 5 ) 623 - 633 2017年01月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Comparison of the benefit feeling rate based on the Sho of OTC kakkonto, cold remedy and cold remedy with kakkonto combination product 査読あり
1. M. Okita, Y. Yayoshi, K. Ohara, A. Negishi, H. Akimoto, N. Inoue, S. Numajiri, S. Ohshima, S. Honma, S. Oshima, D. Kobayashi
Biological and Pharmaceutical Bulletin 40 ( 10 ) 1730 - 1738 2017年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本薬学会
Kakkonto (KK), a traditional Japanese Kampo formulation for cold and flu, is generally sold as an OTC pharmaceuticals used for self-medication. Kampo formulations should be used according to the Shosymptoms of Kampo medicine. These symptoms refer to the subjective symptoms themselves. Although with OTC pharmaceuticals, this is often not the case. We surveyed the relationship of agreement of Sho with the benefit feeling rate (BFR) of patients who took KK (n 555), cold remedies with KK (CK, n 315), and general cold remedies (GC, n 539) using internet research. BFR of a faster recovery was greater in participants who took the medication early and who had confidence in their physical strength in all treatment groups. BFR was significantly higher in the GC group than in the KK group for patients with headache, runny nose, blocked nose, sneezing, and cough. BFR was also significantly higher in the GC group than in the CK group for headache (males) and cough (females). BFR was the highest in the KK group for stiff shoulders. All cold remedies were more effective when taken early, and the larger the number of Sho that a patient had, the greater the BFR increased. Therefore, a cold remedy is expected to be most effective when there are many cold symptoms and when it is taken at an early stage of the common cold.
その他リンク： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b17-00340
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Identification and characteristics of time-related shift in suicide-related event frequency during smoking cessation treatment with varenicline 査読あり
3. H. Akimoto, H. Wakiyama, S. Oshima, A. Negishi, K. Ohara, S. Numajiri, M. Okita, S. Ohshima, N. Inoue, D. Kobayashi
International journal of Medical Sciences 14 ( 10 ) 920 - 926 2017年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Ivyspring International Publisher
Objectives: To survey time-related shifts in number of suicide-related events (SRE) during smoking cessation treatment with varenicline (VAR) in cases from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), as well as the characteristics of these shifts.Methods: We isolated cases from the FAERS database involving VAR usage where SRE was reported as an adverse event (SRE+/VAR+ case) and established a histogram of SRE+/VAR+ case numbers per week. Furthermore, we focused on “cases reporting specific adverse events prior to drug usage start” using X-bar and R chart concepts. We also attempted to exclude the influence of smoking history from the created histogram. Moreover, we constructed a histogram on central nervous system adverse events, which were frequently seen during VAR usage.Results: By removing the effects of smoking history, SRE onset signals were detected over a long period from the start of VAR use. However, expression signals for nausea and abnormal dreams were detected only in the early VAR administration period.Discussion: These results suggest that VAR use-induced SRE is expressed over a long timeframe from the start of treatment. Additionally, the period of SRE expression signal detection was longer than that of the other central nervous system adverse events (nausea and abnormal dreams). Therefore, SRE onset must be carefully monitored during smoking cessation treatment with VAR over the entire treatment period.
その他リンク： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-ijms.19877
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Assessment of the Risk of Suicide-Related Events Induced by Concomitant Use of Antidepressants in Cases of Smoking Cessation Treatment with Varenicline and Assessment of Latent Risk by the Use of Varenicline 査読あり
Hayato Akimoto, Shinji Oshima, Akio Negishi, Kousuke Ohara, Shigeru Ohshima, Naoko Inoue, Daisuke Kobayashi
PLoS One 11 ( 9 ) 2016年09月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1371
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Identification of the discrepancies between pharmacists' and patients' perception of the pharmacist's role as an advisor on drug therapy based on social science theory 査読あり
6. S. Oshima, K. Senoo, A. Negishi, H. Akimoto, K. Ohara, N. Inoue, S. Ohshima, N. Kutsuma, K. Juni, D. Kobayashi
Biological and Pharmaceutical Bulletin 39 ( 3 ) 313 - 322 2016年03月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本薬学会
Article 25-2 of the Japanese Pharmacists’ Act was revised in June 2014, establishing the position of pharmacists as “advisors on the use of Pharmaceuticals.” Prior to the Act’s revision, we investigated the perceptions of patients and pharmacists about pharmacists’ roles using a social science methodology. We also examined current opinions and necessary factors for the future growth and development of pharmacists. This questionnaire survey was conducted using an internet method. Patients and pharmacists answered 12 questions. Responses from 529 patients and 338 pharmacists were analyzed. For all items, pharmacists’ awareness of their roles exceeded patients’ awareness of the roles. In this study, the difference between pharmacist and patient awareness was larger than in similar research conducted in the United States. The greatest difference was observed in three items: “Understanding the effects of the drugs the patients are taking” (rate of high ratings: pharmacists 80.2%, patients 37.8%), “Understanding the health changes caused by the drugs dispensed to the patients” (pharmacists 80.2%, patients 28.4%), and “Consciously protecting patients from the adverse effects of drugs” (pharmacists 82.8%, patients 42.2%), indicating role discrepancy. Partition analysis indicated the three factors for a pharmacist to be regarded as a drug therapy or medication specialist: “The patient regards the pharmacist as his/her family or regular pharmacist,” “The pharmacist is making it easy for a patient to talk with him/her” and “The pharmacist is aware of a patient’s use of products other than prescribed drugs, such as over the counter (OTC) medications or health foods and nutritional supplements.” Future efforts are necessary to resolve role discrepancy and implement ongoing monitoring.
DOI： info:doi/10.1248/bpb.b15-00565
その他リンク： http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b15-00565
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Possibility and effectiveness of drug delivery to skin by needle-free injector 査読あり
Naoko Inoue, Hiroaki Todo, Dai Iidaka, Yoshihiro Tokudome, Fumie Hashimoto, Tohru Kishino, Kenji Sugibayashi
International Journal of Pharmaceutics 391 65 - 72 2013年03月
記述言語：英語 掲載種別：学位論文（その他）
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Synergistic effects of iontophoresis and jet injector pretreatment on the in-vitro skin permeation of diclofenac and angiotensin Ⅱ 査読あり
Kenji Sugibayashi, Midori Kagino, Sachihiko Numajiri, Naoko Inoue, Daisuke Kobayashi, Masayuki Kimura, Masatoshi Yamaguchi, Yasunori Morimoto
Journal of Pharmacy and Pharmacology 52 1179 - 1186 2013年03月
記述言語：英語 掲載種別：学位論文（その他）
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Fundamental investigation of a novel drug delivery system, a transdermal delivery system with jet injection 査読あり
Naoko Inoue, Daisuke Kobayashi, Masayuki Kimura, Machiji Toyama, Isamu Sugawara, Shinji Itoyama, Masahiko Ogihara, Kenji Sugibayashi,Yasunori Morimoto
International Journal of Pharmaceutics 137 75 - 84 2013年03月
記述言語：英語 掲載種別：学位論文（その他）