論文 - 菊地 秀与
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Differentiation induction of human breast cancer cells by arsenite in combination with tetrandrine 査読あり 国際誌
Bowen Yu, Bo Yuan, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Xiaohua Pei, and Norio Takagi
American Journal of Translational Research 11 ( 12 ) 7310 - 7323 2019年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Hidetomo Kikuchi, Bo Yuan, Xiaomei Hu, Mari Okazaki
American Journal of Cancer Research 9 ( 8 ) 1517 - 1535 2019年08月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：e-Century Publishing Corporation
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Yuta Yoshino, Bo Yuan, Saki Okusumia, Reiji Aoyama, Ryo Murota, Hidetomo Kikuchi, Norio Takagi, Hiroo Toyoda
Chemico-Biological Interactions 294 9 - 17 2018年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：ELSEVIER
Among five major anthocyanin compounds, delphinidin exhibited the most potent and selective cytocidal effect against HL-60, a trivalent arsenic (As(III))-resistant cell line. Co-treatment with delphinidin and As(III) resulted in the reduction of IC50 value for As(III) from 11.2 to 1.5 μM, which was considered as clinically achieved concentrations of As(III). The combination treatment strongly preferred to selectively enhance the cytotoxicity of As(III) against HL-60 cells rather than human peripheral blood mononuclear cells. The induction of apoptosis as evidenced by the increase of sub-G1 cells, DNA fragmentation, annexin V-positive cells and the activation of caspase-8, -9 and -3 was observed in HL-60 cells co-treated with As(III) and delphinidin. Similar to the activation pattern of caspases, a substantial decrease in the expression level of Bid along with the loss of mitochondrial membrane potential was also observed. These results suggested that the combination treatment triggered a convergence of the intrinsic and extrinsic pathways of apoptosis via the activation of caspase-8 and cleaved Bid. Delphinidin itself significantly decreased the intracellular GSH ([i]GSH) and nuclear factor-κB (NF-κB) binding activity, and further returned As(III)-triggered increment of [i]GSH and enhancement of NF-κB binding activity to control level. Additionally, buthionine sulfoximine, a GSH depletor; JSH-23, a NF-κB inhibitor, also mimicked the capacity of delphinidin to significantly induce the reduction of [i]GSH along with the potentiation of As(III) cytotoxicity in HL-60 cells. These observations suggested that delphinidin-induced sensitization of HL-60 cells to As(III) was caused by the reduction of [i]GSH, which was probably associated with the inhibitory effect of delphinidin on NF-κB binding activity. These findings further suggest that delphinidin-induced sensitization of HL-60 cells to As(III) may lead to dose reduction of As(III) in clinical application, and ultimately contribute to minimizing its side effects.
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Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs 査読あり 国際誌
Atsuko Ohkubo, Tomomi Chida, Hidetomo Kikuchi, Tadashi Tsuda, Katsuyoshi Sunaga
Asian Journal of Pharmaceutical Sciences 12 ( 5 ) 464 - 469 2017年09月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Elsevier
We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (NFP) and midazolam (MDZ), in male Wistar rats. Oral administration of GFJ 90 min before the intraduodenal administration of NFP or MDZ increased the area under the concentration–time curves (AUCs) of NFP and MDZ by 32.4% and 89.4%, respectively. TJ increased MDZ blood concentrations and AUC after intraduodenal MDZ administration; however, it had no effect on NFP. When MDZ and NFP were intravenously administered, GFJ significantly increased the AUC of MDZ, but only slightly increased that of NFP. In contrast, TJ only slightly increased the AUC of MDZ. These results suggest that, similar to GFJ, TJ influences the pharmacokinetics of CYP3A4-substrate drugs; however, it may be a drug-dependent partial effect.
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Hidetomo Kikuchi, Satomi Kogure, Rie Arai, Kouki Saino, Atsuko Ohkubo, Tadashi Tsuda and Katsuyoshi Sunaga
Biomedical Reports 6 ( 5 ) 539 - 544 2017年05月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Spandidos Publications
Rosehip, the fruit of Rosa canina L., has traditionally been used to treat urate metabolism disorders; however, its effects on such disorders have not been characterized in detail. Therefore, the present study investigated the effects of hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO) activity in vitro. In addition, the serum urate lowering effects of the rosehip hot water extract in a mouse model of hyperuricemia (male ddY mice, which were intraperitoneally injected with potassium oxonate) were investigated. Furthermore, the influence of rosehip hot water extract on CYP3A4 activity, which is the most important drug‑metabolizing enzyme from a herb‑drug interaction perspective, was investigated. Rosehip extracts of hot water, ethanol and ethyl acetate inhibited XO activity [half maximal inhibitory concentration (IC50) values: 259.6±50.6, 242.5±46.2 and 1,462.8±544.2 µg/ml, respectively]. Furthermore, the administration of 1X rosehip hot water extract significantly reduced the levels of serum urate at 8 h, which was similar when compared with the administration of 1 mg/kg allopurinol. Rosehip hot water extract only marginally affected CYP3A4 activity (IC50 value, >1 mg/ml). These findings indicate that rosehip hot water extract may present as a functional food for individuals with a high urate level, and as a therapeutic reagent for hyperuricemic patients.
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Hidetomo Kikuchi, Bo Yuan, Eisuke Yuhara, Masahiko Imai, Ryota Furutani, Shin Fukushima, Shingo Hazama, Chieko Hirobe, Kunio Ohyama, Norio Takagi, Hiroo Toyoda
International Journal of Oncology 45 ( 2 ) 843 - 852 2014年08月
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Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines 査読あり 国際誌
Hidetomo Kikuchi, Bo Yuan, Yoshio Nishimura, Masahiko Imai, Ryota Furutani, Saki Kamoi, Misako Seno, Shin Fukushima, Shingo Hazama, Chieko Hirobe, Kunio Ohyama, Xiao-Mei Hu, Norio Takagi, Toshihiko Hirano, Hiroo Toyoda
International Journal of Oncology 43 ( 6 ) 1976 - 1984 2013年12月
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Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60 査読あり 国際誌
Hidetomo Kikuchi, Bo Yuan, Eisuke Yuhara, Norio Takagi, Hiroo Toyoda
International Journal of Oncology 43 ( 6 ) 2046 - 2056 2013年12月
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Contribution of membrane progesterone receptor α to the induction of progesterone-mediated apoptosis associated with mitochondrial membrane disruption and caspase cascade activation in Jurkat cell lines 査読あり 国際誌
Asami Kon, Bo Yuan, Tomoyuki Hanazawa, Hidetomo Kikuchi, Mari Sato, Ryota Furutani, Norio Takagi, Hiroo Toyoda
Oncology Reports 30 ( 4 ) 1965 - 1970 2013年10月
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Growth inhibition of a human colon carcinoma cell, COLO 201, by a natural product, Vitex agnus-castus fruits extract, in vivo and in vitro 査読あり 国際誌
Masahiko Imai, Bo Yuan, Hidetomo Kikuchi, Mai Saito, Kunio Ohyama, Chieko Hirobe, Takashi Oshima, Takahiro Hosoya, Hiroshi Morita, Hiroo Toyoda
Advances in Biological Chemistry 2 ( 1 ) 20 - 28 2012年02月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Scientific Research Publishing
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Heat Shock Response in Human Epithelial Colorectal Adenocarcinoma Caco-2 Cells
Sachiye Inouye, Michiko Ohno, Hidetomo Kikuchi, Reiko Akagi
Journal of Yasuda Women’s University 40 383 - 388 2012年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Yasuda Women’s University
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Enhanced growth inhibitory effect of 5-fluorouracil in combination with Vitex agnus-castus fruits extract against a human colon adenocarcinoma cell line, COLO 201 査読あり 国際誌
Masahiko Imai, Hidetomo Kikuchi, Bo Yuan, Yoko Aihara, Ayuko Mizokuchi, Kunio Ohya-Ma, Chieko Hirobe, Hiroo Toyoda
Journal of Chinese Clinical Medicine 6 ( 4 ) 14 - 19 2011年08月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: a potential natural anti-cancer substance 査読あり 国際誌
Masahiko Imai, Hidetomo Kikuchi, Takanori Denda, Kunio Ohyama, Chieko Hirobe, Hiroo Toyoda
Cancer letters 276 ( 1 ) 74 - 80 2009年04月