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Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences |
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Professor |
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YAMANOI Takashi
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Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Professor
2014.04
Papers 【 display / non-display 】
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Transglycosylation behavior of Mucor hiemalis endo-β-N-acetylglucosaminidase to β-cyclodextrin derivatives with multivalent glucose moieties for synthesizing cyclodextrin-based oligosaccharide clusters Reviewed
Yusuke Tomabechi, Yoshiki Oda, Kenji Yamamoto, Takashi Yamanoi
Carbohydrate Research 548 in press 2025
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a thiourea organocatalyst Reviewed
Taro Koda, Hiroshi Akutsu, Mitsuaki Suzuki, Kosuke Nakashima, Shin-ichi Hirashima, Akihiro Yoshida, Tsuyoshi Miura, Takashi Yamanoi
Tetrahedron letters 255 in press 2025
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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A Synthetic Approach for Hepta-Branched β-Cyclodextrins Bearing Heterogeneous Carbohydrate Residues at Their Primary Side via a One-Pot Process with a Simultaneous Click Chemistry Reaction Reviewed
Yoshiki Oda, Takashi Yamanoi
Synlett 35 1417 - 1422 2024.01
Language：English Publishing type：Research paper (scientific journal)
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Preparation of Fluorous Aza-crown Ether with Two Bisfluorous Chain Type Propionyl Groups: An Investigation of its Partition Ratios in Fluorous Biphasic Systems and Recyclability During SN2-type Acetoxylation Reactions Reviewed
Takashi Yamanoi, Kenji Koike and Yoshiki Oda
Letters in Organic Chemistry 24 ( 1 ) 12 - 15 2024.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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β-Cyclodextrins bearing ethylene glycol chains at their primary side: their preparations and evaluation as solubilizing agents for 17-β-estradiol and nuclear magnetic resonance structural analysis of a 17-β-estradiol inclusion complex Reviewed
Yoshiki Oda, Junki Nakagawa, Kaname Kasturaya, and Takashi Yamanoi
Journal Inclusion Phenomena & Macrocyclic Chemistry 103 421 - 428 2023.12
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
Misc 【 display / non-display 】
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Stereoselectivity of D-psicofuranosylation reactions catalyzed by scandium triflate Reviewed
T. Yamanoi, T. Ishiyama, and M. Watanabe
Proceedings of the Fifth Symposium of International Society of Rare Sugars 29 - 33 2011
Authorship：Lead author Language：English Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings)
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Reactions and uses of artificial ketoses Invited Reviewed
T. Yamanoi and S. Matsuda
Heterocycles 79 163 - 194 2009
Authorship：Lead author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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H and 13C DOSY spectra of the mixed sample of α-cyclodextrin and phenyl alpha-D-(13C6)glucopyranoside Reviewed
Y. Oda, S. Matsuda, T. Yamanoi, A. Murota, and K. Katsuraya
Proceeding of the 14th International Symposium on Cyclodextrins 417 - 420 2008
Authorship：Lead author Language：English Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings)
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Synthetic approach from D-mannose to 2,7-anhydro-D-sedoheptulose Reviewed
S. Matsuda and T. Yamanoi
Proceedings of the Fourth Symposium of International Society of Rare Sugars 84 - 88 2008
Language：English Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings)
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Glycosidation of the rare sugars, L-fructose and D-psicose Reviewed
T. Ishiyama, T. Yamanoi, and M. Watanabe
Proceedings of the Fourth Symposium of International Society of Rare Sugars 76 - 80 2008
Language：English Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings)
Presentations 【 display / non-display 】
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シクロデキストリンによるドキソルビシン会合構造体のＮＭＲ解析
鬘谷 要, 小田慶喜, 山ノ井孝
第35回シクロデキストリンシンポジウム 日本シクロデキストリン学会
Event date： 2018.09
Language：Japanese Presentation type：Poster presentation
Venue：甲府
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糖鎖抗原を用いた迅速な多包虫症診断法の開発
小泉 晶彦、安保 秀美、山ノ井 孝
第37回糖質学会
Event date： 2018.08
Language：Japanese Presentation type：Poster presentation
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Synthesis of β-cyclodextrin derivatives multivalently conjugated with carbohydrate moieties through click chemistry reaction International conference
Y. Oda, J. Nakagawa, M. Watanabe, T. Yamanoi
The 19th International Cyclodextrin Symposium
Event date： 2018.04
Language：English Presentation type：Poster presentation
Venue：東京
The cyclodextrins (CyDs) play a functional role as scaffold molecules for enabling to conjugate organic compounds to CyDs via co-valent bonds. The structural feature of CyDs usefully leads to the development of CyD-based functional materials. In CyD chemistry, it is currently one of the most significant subjects to develop the scaffold use of CyD molecules. The CyD derivatives with multivalent carbohydrate ligands are expected to be drug carriers. Therefore, this study describes the design and synthesis of newly several β-CyD derivatives multivalently conjugated with carbohydrate moieties through click chemistry reaction.
Scheme 1 presents the synthetic approch for the β-CyD derivative 3 conjugated with seven glucopyranose moieties from β-CyD and β-arbutin (natural product, p-hydroxyphenyl β-D-glucopyranoside). The azide-alkyne Huisgen cycloaddition between the acetylated β-arbutin derivative 1 with a propargyl group and the acetylated hepta(6-azido-6-deoxy)-β-CyD derivative 2 using CuSO4 and sodium ascorbate in THF / H2O (1 / 1) was smoothly promoted by microwave irradation to afforded the precursor, acetyl protected β-CyD derivative. The following deacetylation of 3 gave the desired β-CyD derivative 3 in good yield.
Several types of β-CyD derivatives with seven carbohydrate moieties from α-arbutin (p-hydroxyphenyl α-D-glucopyranoside), mannopyranose (Man) or 2-acetoamido-2-deoxy-glucopyranose (GlcNAc), were also sucessfully demonstrated. Furthermore, we investigated the synthesis of hybride types of β-CyD derivatives multivalently with mixed carbohydrates moieties (β-arbutin, α-arbutin, Man, and GlcNAc). -
インフルエンザウイルス捕獲機能を有する糖鎖多分岐シクロデキストリン誘導体の合成研究 International conference
山ノ井孝、小田慶喜、苫米地祐輔、中川純樹、渡邊幹夫、山本憲二
第34回シクロデキストリンシンポジウム シクロデキストリン学会
Event date： 2017.08 - 2017.09
Language：Japanese Presentation type：Oral presentation (general)
Venue：名古屋
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Endo-M酵素を用いたグルコース七残基分岐β-CyDへのN-結合型糖 鎖の集積化
苫米地 祐輔, 中川 純樹, 渡邊 幹夫, 小田 慶喜, 山本 憲二, 山ノ 井 孝
第36回日本糖質学会年会 日本糖質学会
Event date： 2017.07
Language：Japanese Presentation type：Poster presentation
Venue：旭川
Committee Memberships 【 display / non-display 】
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東京糖鎖研究会 幹事会員
2016.04
Committee type：Academic society
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日本糖質学会 評議員
2003.07
Committee type：Academic society
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シクロデキストリン学会 評議員
2003.04
Committee type：Academic society