Papers - MATSUZAKI Hirokazu
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A ferulic acid derivative FAD012 protects brain microvascular endothelial cells from H2O2-induced ferroptosis via NRF2 activation Reviewed
Toshiya Aoyama; Meiyan Xuan; Satoshi Kitaoka; Jun Takayama; Bo Yuan; Hirokazu Matsuzaki; Yuya Egawa; Takeshi Sakamoto; Mari Okazaki
European journal of pharmacology 1025 178926 2026.05
Language：English
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Design and Synthesis of Ferulic Acid Derivatives with Enhanced Antioxidant and Neuroprotective Activities: Discovery of Dual Antioxidant Agent Reviewed
Koichi Shikama; Jun Takayama; Meiyan Xuan; Hirokazu Matsuzaki; Bo Yuan; Hiroyuki Teramae; Mari Okazaki and Takeshi Sakamoto
AppliedChem 5 ( 4 ) 37 2025.12
Language：English
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FAD012, a Ferulic Acid Derivative, Preserves Cerebral Blood Flow and Blood–Brain Barrier Integrity in the Rat Photothrombotic Stroke Model Reviewed
Hiroshi Sugoh; Hirokazu Matsuzaki; Jun Takayama; Naohiro Iwata; Meiyan Xuan; Bo Yuan; Takeshi Sakamoto; Mari Okazaki
Biomedicines 13 ( 10 ) 2403 2025.09
Authorship：Second author Language：English
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CUD003, a Novel Curcumin Derivative, Ameliorates LPS-Induced Impairment of Endothelium-Dependent Relaxation and Vascular Inflammation in Mice Reviewed
Hirokazu Matsuzaki; Anna Arai; Meiyan Xuan; Bo Yuan; Jun Takayama; Takeshi Sakamoto; Mari Okazaki
International journal of molecular sciences 26 ( 18 ) 8850 2025.09
Authorship：Lead author Language：English
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Administration of Ascorbic Acid Alleviates Neuronal Damage After Cerebral Ischemia in ODS Rats Reviewed
Naohiro Iwata; Naoto Ogawa; Tom Imai; Siti Sabirah Binti Ridzuan; Shinya Kamiuchi; Hirokazu Matsuzaki; Meiyan Xuan; Bo Yuan; Mari Okazaki; Yasuhide Hibino
Antioxidants 14 ( 7 ) 773 2025.06
Language：English
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Chronic Administration with FAD012 (3,5-Dimethyl-4-hydroxycinnamic Acid) Maintains Cerebral Blood Flow and Ameliorates Swallowing Dysfunction After Chronic Cerebral Hypoperfusion in Rats Reviewed
Takashi Asano, Hirokazu Matsuzaki, Meiyan Xuan, Bo Yuan, Jun Takayama, Takeshi Sakamoto, Mari Okazaki
International journal of molecular sciences 26 ( 7 ) 3277 2025.04
Language：English
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Involvement of the Restoration of Cerebral Blood Flow and Maintenance of eNOS Expression in the Prophylactic Protective Effect of the Novel Ferulic Acid Derivative FAD012 against Ischemia/Reperfusion Injuries in Rats Reviewed
International journal of molecular sciences 24 ( 11 ) 2023.06
Language：English
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Enhanced Cytotoxic Effects of Arenite in Combination with Active Bufadienolide Compounds against Human Glioblastoma Cell Line U-87 Reviewed
Molecules 27 ( 19 ) 2022
Language：English Publishing type：Research paper (scientific journal)
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Delivery of acetaminophen to the central nervous system and the pharmacological effect after intranasal administration with a mucoadhesive agent and absorption enhancer Reviewed
International journal of pharmaceutics 594 ( 120046 ) 2021
Language：English Publishing type：Research paper (scientific journal)
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Perfluorododecanoic Acid Induces Cognitive Deficit in Adult Rats Reviewed
Kohei Kawabata, Hirokazu Matsuzaki, Sahoko Nukui, Mari Okazaki, Ayako Sakai, Yoichi Kawashima and Naomi Kudo
Toxicological sciences 157 ( 2 ) 421 - 428 2017
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
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Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats Reviewed
Takashi Asano, Hirokazu Matsuzaki, Naohiro Iwata, Meiyan Xuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto and Mari Okazaki
International journal of molecular sciences 18 ( 3 ) 550 2017
Authorship：Second author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3390/ijms18030550
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霊芝菌糸体培養培地抽出物のラット骨格筋培養細胞におけるGLUT4膜移行促進作用 Reviewed
神内 伸也，西川 祐未，岡邑 香里，岩田 直洋，臼井 達洋，岡﨑 真理，松崎 広和，宮野 義之，飯塚 博，浅野 哲，日比野 康英
日本補完代替医療学雑誌 12 19 - 27 2015
Language：Japanese Publishing type：Research paper (scientific journal)
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Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats Reviewed
Naohiro Iwata, Hiroko Takayama, Meiyan Xuan, Shinya Kamiuchi, Hirokazu Matsuzaki, Mari Okazaki, and Yasuhide Hibino
BioMed research international 2015 189292 2015
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1155/2015/189292
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Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain Reviewed
Meiyan Xuan, Mari Okazaki, Naohiro Iwata, Satoshi Asano, Shinya Kamiuchi, Hirokazu Matsuzaki, Takeshi Sakamoto, Yoshiyuki Miyano, Hiroshi Iizuka, Yasuhide Hibino
Evidence-Based Complementary and Alternative Medicine 2015
Language：English Publishing type：Research paper (scientific journal)
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Orally administrated ascorbic acid suppresses neuronal damage and modifies expression of SVCT2 and GLUT1 in the brain of diabetic rats with cerebral ischemia-reperfusion. Reviewed
Iwata N, Okazaki M, Xuan M, Kamiuchi S, Matsuzaki H, Hibino Y
Nutrients 6 1554 - 1577 2014
Language：English Publishing type：Research paper (scientific journal)
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2 型糖尿病マウスの肝臓における霊芝菌糸体培養培地抽出物 (WER) の糖質代謝に与える影響 Reviewed
神内 伸也，新藤 由梨，内海 有香，岩田 直洋，岡﨑 真理，鈴木 史子，飯塚 博，浅野 哲，松崎 広和，日比野 康英
日本補完代替医療学雑誌 11 57 - 66 2014
Language：Japanese Publishing type：Research paper (scientific journal)
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Matrin 3 Augments the Transcriptional Activity of an SV40 Promoter-Mediated Luciferase Gene with a Highly Repetitive DNA Component Reviewed
Shinya Kamiuchi, Mutsumi Fukaya, Tatsuhiro Usui, Naohiro Iwata, Mari Okazaki, Hirokazu Matsuzaki, Katsuyoshi Sunaga, Yasuhide Hibino
Journal of molecular and genetic medicine 8 146 2014
Language：English Publishing type：Research paper (scientific journal)
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Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats Reviewed
Hirokazu Matsuzaki, Yuta Shimizu, Naohiro Iwata, Shinya Kamiuchi, Fumiko Suzuki, Hiroshi Iizuka, Yasuhide Hibino, Mari Okazaki
BMC complementary and alternative medicine 26 ( 13 ) 370 2013.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effects of serotonergic terminal lesion in the amygdala on conditioned fear and innate fear in rats Reviewed
Takeshi Izumi, Yu Ohmura, Yukino Futami, Hirokazu Matsuzaki, Yasunori Kubo, Takayuki Yoshida, Mitsuhiro Yoshioka
European journal of pharmacology 2012.08
Language：English Publishing type：Research paper (scientific journal)
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Diabetes-mediated exacerbation of neuronal damage and inflammation after cerebral ischemia in rat: Protective effects of water-soluble extract from culture medium of Ganoderma lucidum mycelia. Reviewed
Iwata N., Okazaki M., Nakano R., Kasahara C., Kamiuchi S., Suzuki F., Iizuka H., Matsuzaki H., Hibino Y.
Cerebral Ischemia/Book 1 2012.04
Language：English Publishing type：Research paper (scientific journal)