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Affiliation |
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry |
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Title |
Assistant Professor |
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External Link |
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KAMAUCHI Hitoshi
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Research Areas 【 display / non-display 】
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Life Science / Environmental and natural pharmaceutical resources
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Life Science / Pharmaceutical chemistry and drug development sciences
From School 【 display / non-display 】
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Meiji Pharmaceutical University Faculty of Pharmaceutical Science Graduated
2006.04 - 2010.03
Country：Japan
From Graduate School 【 display / non-display 】
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
2015.04 - 2018.03
Country：Japan
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Meiji Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences Master's Course Completed
2013.04 - 2015.03
Country：Japan
Employment Record in Research 【 display / non-display 】
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Assistant Professor
2022.04
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Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry Research Assistant
2018.04 - 2022.03
External Career 【 display / non-display 】
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Meiji Pharmaceutical University Researcher
2011.04 - 2013.03
Country：Japan
Professional Memberships 【 display / non-display 】
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有機合成化学協会
2018.11
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日本薬学会
2013.04
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日本生薬学会
2013.04
Papers 【 display / non-display 】
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Koichi Takao, Yuka Kubota, Kota Kurosaki, Hitoshi Kamauchi, Yoshihiro Uesawa, Yoshiaki Sugita
Chemical and Pharmaceutical Bulletin 72 ( 1 ) 109 - 120 2024.01
Publishing type：Research paper (scientific journal) Publisher：Pharmaceutical Society of Japan
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A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus Curvularia aeria Reviewed
Hitoshi Kamauchi, Mayu Tanaka, Mitsuaki Suzuki, Miho Furukawa, Atsushi Ikeda, Chihiro Sasho, Yuka Kiba, Masashi Kitamura, Koichi Takao, Yoshiaki Sugita
Chemical and Pharmaceutical Bulletin 72 ( 1 ) 98 - 101 2024.01
Authorship：Lead author, Corresponding author Publishing type：Research paper (scientific journal) Publisher：Pharmaceutical Society of Japan
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Synthesis of 2,8-Dioxabicyclo[3.3.1]nonane Derivatives and Their Neuroprotective Activities Reviewed
Hitoshi Kamauchi, Akifumi Takanashi, Mitsuaki Suzuki, Kouki Izumi, Koichi Takao, Yoshiaki Sugita
Chemical and Pharmaceutical Bulletin 72 ( 1 ) 56 - 60 2024.01
Authorship：Lead author, Corresponding author Publishing type：Research paper (scientific journal) Publisher：Pharmaceutical Society of Japan
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Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains. International journal
Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Hitoshi Kamauchi, Taishi Seki, Ryuichiro Suzuki, Masashi Kitamura
Biomedicine & pharmacotherapy 169 115940 - 115940 2023.11
Language：English Publishing type：Research paper (scientific journal)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread as a pandemic and caused damage to people's lives and countries' economies. The spike (S) protein of SARS-CoV-2 contains a cleavage motif, Arg-X-X-Arg, for furin and furin-like enzymes at the boundary of the S1/S2 subunits. Given that cleavage plays a crucial role in S protein activation and viral entry, the cleavage motif was selected as the target. Our previous fluorogenic substrate study showed that osthole, a coumarin compound, inhibits furin-like enzyme activity. In this study, we examined the potential activities of 15 compounds with a structure-activity relationship with osthole, and evaluated their protective ability against SARS-CoV-2 infection. Of the 15 compounds tested, compounds C1 and C2 exhibited the inhibitory effects of osthole against furin-like enzymatic activity; however, little or no inhibitory effects against furin activity were observed. We further examined the inhibition of SARS-CoV-2 activity by compounds C1 and C2 using a Vero E6 cell line that expresses the transmembrane protease serine 2 (TMPRSS2). Compounds C1, C2, and osthole effectively inhibited SARS-CoV-2 infection. Therefore, osthole and its derivatives can potentially be used as therapeutic agents against SARS-CoV-2.
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Hitoshi Kamauchi, Momoka Hirata, Koichi Takao, Yoshiaki Sugita
ACS Omega 7 ( 45 ) 41804 - 41814 2022.11
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：American Chemical Society (ACS)
Misc 【 display / non-display 】
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Discovery of Medicinal Seeds from Chemically Engineered Extracts Invited Reviewed
Journal of Synthetic Organic Chemistry, Japan 77 ( 9 ) 895 - 903 2019.09
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Discovery of Medicinal Seeds from Chemically Engineered Extracts Invited Reviewed
Journal of Synthetic Organic Chemistry, Japan 77 ( 9 ) 895 - 903 2019.09
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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エンドファイト; 特殊環境が生み出す可能性 Invited Reviewed
鎌内 等
ファルマシア 49 ( 4 ) 333 2013.04
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益社団法人日本薬学会
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エンドファイト; 特殊環境が生み出す可能性 Invited Reviewed
鎌内 等
ファルマシア 49 ( 4 ) 333 - 333 2013.04
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益社団法人日本薬学会
Presentations 【 display / non-display 】
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菌糸-バイオフィルム形成阻害をターゲットとした真菌由来天然物の誘導体合成
鎌内 等, 木村 由, 牛渡 美琴, 關 大志, 鈴木 光明, 平田 桃香, 高尾 浩一, 杉田 義昭
第63回天然有機化合物討論会 2021.09
Event date： 2021.09
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芳香族-テルペノイド天然物の誘導体合成と神経保護作用の評価
鎌内 等, 小田 拓未, 堀内 加奈世, 高尾 浩一, 杉田 義昭
第61回天然有機化合物討論会 2019.09
Event date： 2019.09
Awards 【 display / non-display 】
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長井記念若手薬学研究者賞
2023.03 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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長井記念若手薬学研究者賞
2023.03 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成28年度長井記念薬学研究奨励支援
2016 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成28年度長井記念薬学研究奨励支援
2016 日本薬学会
鎌内 等
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Scientific Research Funds Acquisition Results 【 display / non-display 】
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天然由来化合物を基盤とした菌糸形成阻害による「予防的」抗真菌薬の開発
Grant number：20K16029 2020.04 - 2023.03
科学研究費助成事業 若手研究
鎌内等
Authorship：Principal investigator Grant type：Competitive
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天然由来化合物を基盤とした菌糸形成阻害による「予防的」抗真菌薬の開発
2020.01 - 2023.03
科学研究費補助金 若手研究
鎌内等